Cognitive impairments in type 1 diabetes mellitus
Type 1 diabetes mellitus (DM) is one of the most prevalent endocrinological disorders of childhood. This disorder is accompanied by numerous micro- and macrovascular complications that reduce children’s life expectancy and increase healthcare costs. Central nervous system (CNS) damage in children an...
| Main Authors: | , |
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| Format: | Article |
| Language: | Russian |
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Russian Academy of Sciences, Siberian Branch Publishing House
2023-02-01
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| Series: | Сибирский научный медицинский журнал |
| Subjects: | |
| Online Access: | https://sibmed.elpub.ru/jour/article/view/963 |
| _version_ | 1826575676791062528 |
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| author | Yu. V. Bykov V. A. Baturin |
| author_facet | Yu. V. Bykov V. A. Baturin |
| author_sort | Yu. V. Bykov |
| collection | DOAJ |
| description | Type 1 diabetes mellitus (DM) is one of the most prevalent endocrinological disorders of childhood. This disorder is accompanied by numerous micro- and macrovascular complications that reduce children’s life expectancy and increase healthcare costs. Central nervous system (CNS) damage in children and adolescents with type 1 DM is a fairly common but poorly studied complication. The leading role among CNS changes is played by cognitive dysfunction (CD). The pathophysiological aspects of CD in type 1 DM haven’t yet been understood completely. The three main triggers are hypoglycemia, chronic moderate hyperglycemia, and acute hyperglycemia (diabetic ketoacidosis). Evidence is presented to show the development of morphological abnormalities of the brain with progression of type 1 DM in children. Damage in the formation of white and gray matter, hippocampus, amygdala, the processes of myelination disorders have been described, which can also be the cause of CD development in this contingent of patients. Peculiarities ofclinical manifestations of CD in children and adolescents with type 1 DM depending on the localization of the brain lesion are described. A more pronounced CD was found in cases when DM debuts in early childhood (up to 5 years). Timely diagnosis and correction of CD in children and adolescents with type 1 DM can improve the therapeutic and prophylactic prognosis in this disease. |
| first_indexed | 2024-03-08T14:32:38Z |
| format | Article |
| id | doaj.art-10507d435c544f6dbc2d84b4944ef408 |
| institution | Directory Open Access Journal |
| issn | 2410-2512 2410-2520 |
| language | Russian |
| last_indexed | 2025-03-14T13:18:29Z |
| publishDate | 2023-02-01 |
| publisher | Russian Academy of Sciences, Siberian Branch Publishing House |
| record_format | Article |
| series | Сибирский научный медицинский журнал |
| spelling | doaj.art-10507d435c544f6dbc2d84b4944ef4082025-02-28T13:43:58ZrusRussian Academy of Sciences, Siberian Branch Publishing HouseСибирский научный медицинский журнал2410-25122410-25202023-02-0143141210.18699/SSMJ20230101473Cognitive impairments in type 1 diabetes mellitusYu. V. Bykov0V. A. Baturin1Stavropol State Medical University of Minzdrav of Russia; Children’s City Clinical Hospital named G.K. FilippskyStavropol State Medical University of Minzdrav of RussiaType 1 diabetes mellitus (DM) is one of the most prevalent endocrinological disorders of childhood. This disorder is accompanied by numerous micro- and macrovascular complications that reduce children’s life expectancy and increase healthcare costs. Central nervous system (CNS) damage in children and adolescents with type 1 DM is a fairly common but poorly studied complication. The leading role among CNS changes is played by cognitive dysfunction (CD). The pathophysiological aspects of CD in type 1 DM haven’t yet been understood completely. The three main triggers are hypoglycemia, chronic moderate hyperglycemia, and acute hyperglycemia (diabetic ketoacidosis). Evidence is presented to show the development of morphological abnormalities of the brain with progression of type 1 DM in children. Damage in the formation of white and gray matter, hippocampus, amygdala, the processes of myelination disorders have been described, which can also be the cause of CD development in this contingent of patients. Peculiarities ofclinical manifestations of CD in children and adolescents with type 1 DM depending on the localization of the brain lesion are described. A more pronounced CD was found in cases when DM debuts in early childhood (up to 5 years). Timely diagnosis and correction of CD in children and adolescents with type 1 DM can improve the therapeutic and prophylactic prognosis in this disease.https://sibmed.elpub.ru/jour/article/view/963type 1 diabetes mellituscognitive dysfunctionchildren and adolescentsbrain |
| spellingShingle | Yu. V. Bykov V. A. Baturin Cognitive impairments in type 1 diabetes mellitus Сибирский научный медицинский журнал type 1 diabetes mellitus cognitive dysfunction children and adolescents brain |
| title | Cognitive impairments in type 1 diabetes mellitus |
| title_full | Cognitive impairments in type 1 diabetes mellitus |
| title_fullStr | Cognitive impairments in type 1 diabetes mellitus |
| title_full_unstemmed | Cognitive impairments in type 1 diabetes mellitus |
| title_short | Cognitive impairments in type 1 diabetes mellitus |
| title_sort | cognitive impairments in type 1 diabetes mellitus |
| topic | type 1 diabetes mellitus cognitive dysfunction children and adolescents brain |
| url | https://sibmed.elpub.ru/jour/article/view/963 |
| work_keys_str_mv | AT yuvbykov cognitiveimpairmentsintype1diabetesmellitus AT vabaturin cognitiveimpairmentsintype1diabetesmellitus |