C7orf59/LAMTOR4 phosphorylation and structural flexibility modulate Ragulator assembly

C7orf59/LAMTOR4 phosphorylation and structural flexibility modulate Ragulator assembly

Ragulator is a pentamer composed of p18, MP1, p14, C7orf59, and hepatitis B virus X‐interacting protein (HBXIP; LAMTOR 1—5) which acts as a lysosomal scaffold of the Rag GTPases in the amino acid sensitive branch of TORC1 signaling. Here, we present the crystal structure of human HBXIP‐C7orf59 dimer...

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Bibliographic Details
Main Authors: Nadia Rasheed, Tatiani B. Lima, Gustavo F. Mercaldi, Andrey F.Z. Nascimento, Ana L.S. Silva, Germanna L. Righetto, Liron Bar‐Peled, Kuang Shen, David M. Sabatini, Fabio C. Gozzo, Ricardo Aparicio, Juliana H.C. Smetana
Format: Article
Language:English
Published: Wiley 2019-09-01
Series:FEBS Open Bio
Subjects:
LAMTOR
mTOR
PKA
protein phosphorylation
protein structure
Ragulator
Online Access:https://doi.org/10.1002/2211-5463.12700

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