Analyzing the impact of phthalate and DINCH exposure on fetal growth in a cohort with repeated urine collection
Background: Most previous studies investigating the associations between prenatal exposure to phthalates and fetal growth relied on measurements of phthalate metabolites at a single time point. They also focused on weight at birth without assessing growth over pregnancy, preventing the identificatio...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-04-01
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| Series: | Environment International |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412024001703 |
| _version_ | 1797249190812712960 |
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| author | Marion Ouidir Paulina Jedynak Matthieu Rolland Sarah Lyon-Caen Cathrine Thomsen Amrit K. Sakhi Azemira Sabaredzovic Sam Bayat Rémy Slama Claire Philippat |
| author_facet | Marion Ouidir Paulina Jedynak Matthieu Rolland Sarah Lyon-Caen Cathrine Thomsen Amrit K. Sakhi Azemira Sabaredzovic Sam Bayat Rémy Slama Claire Philippat |
| author_sort | Marion Ouidir |
| collection | DOAJ |
| description | Background: Most previous studies investigating the associations between prenatal exposure to phthalates and fetal growth relied on measurements of phthalate metabolites at a single time point. They also focused on weight at birth without assessing growth over pregnancy, preventing the identification of potential periods of fetal vulnerability. We examined the associations between pregnancy urinary phthalate metabolites and fetal growth outcomes measured twice during pregnancy and at birth. Methods: For 484 pregnant women, we assessed 13 phthalate and two 1,2-cyclohexane dicarboxylic acid, diisononyl ester (DINCH) metabolite concentrations from two within-subject weekly pools of up to 21 urine samples (median of 18 and 34 gestational weeks, respectively). Fetal biparietal diameter, femur length, head and abdominal circumferences were measured during two routine pregnancy follow-up ultrasonographies (median 22 and 32 gestational weeks, respectively) and estimated fetal weight (EFW) was calculated. Newborn weight, length, and head circumference were measured at birth. Associations between phthalate/DINCH metabolite and growth parameters were investigated using adjusted linear regression and Bayesian kernel machine regression models. Results: Detection rates were above 99 % for all phthalate/DINCH metabolites. While no association was observed with birth measurements, mono-iso-butyl phthalate (MiBP) and mono-n-butyl phthalate (MnBP) were positively associated with most fetal growth parameters measured at the second trimester. Specifically, MiBP was positively associated with biparietal diameter, head and abdominal circumferences, while MnBP was positively associated with EFW, head and abdominal circumferences, with stronger associations among males. Pregnancy MnBP was positively associated with biparietal diameter and femur length at third trimester. Mixture of phthalate/DINCH metabolites was positively associated with EFW at second trimester. Conclusions: In this pregnancy cohort using repeated urine samples to assess exposure, MiBP and MnBP were associated with increased fetal growth parameters. Further investigation on the effects of phthalates on child health would be relevant for expanding current knowledge on their long-term effects. |
| first_indexed | 2024-04-24T20:26:33Z |
| format | Article |
| id | doaj.art-1053f8fc74114abfa3dbe718d30dae67 |
| institution | Directory Open Access Journal |
| issn | 0160-4120 |
| language | English |
| last_indexed | 2024-04-24T20:26:33Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Environment International |
| spelling | doaj.art-1053f8fc74114abfa3dbe718d30dae672024-03-22T05:38:27ZengElsevierEnvironment International0160-41202024-04-01186108584Analyzing the impact of phthalate and DINCH exposure on fetal growth in a cohort with repeated urine collectionMarion Ouidir0Paulina Jedynak1Matthieu Rolland2Sarah Lyon-Caen3Cathrine Thomsen4Amrit K. Sakhi5Azemira Sabaredzovic6Sam Bayat7Rémy Slama8Claire Philippat9University Grenoble Alpes, Inserm U 1209, CNRS UMR 5309, Team of Environmental Epidemiology Applied to Development and Respiratory Health, Institute for Advanced Biosciences, 38000, Grenoble, France; Corresponding author.University Grenoble Alpes, Inserm U 1209, CNRS UMR 5309, Team of Environmental Epidemiology Applied to Development and Respiratory Health, Institute for Advanced Biosciences, 38000, Grenoble, FranceUniversity Grenoble Alpes, Inserm U 1209, CNRS UMR 5309, Team of Environmental Epidemiology Applied to Development and Respiratory Health, Institute for Advanced Biosciences, 38000, Grenoble, FranceUniversity Grenoble Alpes, Inserm U 1209, CNRS UMR 5309, Team of Environmental Epidemiology Applied to Development and Respiratory Health, Institute for Advanced Biosciences, 38000, Grenoble, FranceNorwegian Institute of Public Health, Oslo, NorwayNorwegian Institute of Public Health, Oslo, NorwayNorwegian Institute of Public Health, Oslo, NorwayDepartment of Pulmonology and Physiology, Grenoble University Hospital, La Tronche, France; Synchrotron Radiation for Biomedicine Laboratory (STROBE), Inserm UA07, Grenoble Alpes University, Grenoble, FranceUniversity Grenoble Alpes, Inserm U 1209, CNRS UMR 5309, Team of Environmental Epidemiology Applied to Development and Respiratory Health, Institute for Advanced Biosciences, 38000, Grenoble, FranceUniversity Grenoble Alpes, Inserm U 1209, CNRS UMR 5309, Team of Environmental Epidemiology Applied to Development and Respiratory Health, Institute for Advanced Biosciences, 38000, Grenoble, FranceBackground: Most previous studies investigating the associations between prenatal exposure to phthalates and fetal growth relied on measurements of phthalate metabolites at a single time point. They also focused on weight at birth without assessing growth over pregnancy, preventing the identification of potential periods of fetal vulnerability. We examined the associations between pregnancy urinary phthalate metabolites and fetal growth outcomes measured twice during pregnancy and at birth. Methods: For 484 pregnant women, we assessed 13 phthalate and two 1,2-cyclohexane dicarboxylic acid, diisononyl ester (DINCH) metabolite concentrations from two within-subject weekly pools of up to 21 urine samples (median of 18 and 34 gestational weeks, respectively). Fetal biparietal diameter, femur length, head and abdominal circumferences were measured during two routine pregnancy follow-up ultrasonographies (median 22 and 32 gestational weeks, respectively) and estimated fetal weight (EFW) was calculated. Newborn weight, length, and head circumference were measured at birth. Associations between phthalate/DINCH metabolite and growth parameters were investigated using adjusted linear regression and Bayesian kernel machine regression models. Results: Detection rates were above 99 % for all phthalate/DINCH metabolites. While no association was observed with birth measurements, mono-iso-butyl phthalate (MiBP) and mono-n-butyl phthalate (MnBP) were positively associated with most fetal growth parameters measured at the second trimester. Specifically, MiBP was positively associated with biparietal diameter, head and abdominal circumferences, while MnBP was positively associated with EFW, head and abdominal circumferences, with stronger associations among males. Pregnancy MnBP was positively associated with biparietal diameter and femur length at third trimester. Mixture of phthalate/DINCH metabolites was positively associated with EFW at second trimester. Conclusions: In this pregnancy cohort using repeated urine samples to assess exposure, MiBP and MnBP were associated with increased fetal growth parameters. Further investigation on the effects of phthalates on child health would be relevant for expanding current knowledge on their long-term effects.http://www.sciencedirect.com/science/article/pii/S0160412024001703DINCHPhthalatesRepeated urineFetal growthUltrasound measurementBirth outcomes |
| spellingShingle | Marion Ouidir Paulina Jedynak Matthieu Rolland Sarah Lyon-Caen Cathrine Thomsen Amrit K. Sakhi Azemira Sabaredzovic Sam Bayat Rémy Slama Claire Philippat Analyzing the impact of phthalate and DINCH exposure on fetal growth in a cohort with repeated urine collection Environment International DINCH Phthalates Repeated urine Fetal growth Ultrasound measurement Birth outcomes |
| title | Analyzing the impact of phthalate and DINCH exposure on fetal growth in a cohort with repeated urine collection |
| title_full | Analyzing the impact of phthalate and DINCH exposure on fetal growth in a cohort with repeated urine collection |
| title_fullStr | Analyzing the impact of phthalate and DINCH exposure on fetal growth in a cohort with repeated urine collection |
| title_full_unstemmed | Analyzing the impact of phthalate and DINCH exposure on fetal growth in a cohort with repeated urine collection |
| title_short | Analyzing the impact of phthalate and DINCH exposure on fetal growth in a cohort with repeated urine collection |
| title_sort | analyzing the impact of phthalate and dinch exposure on fetal growth in a cohort with repeated urine collection |
| topic | DINCH Phthalates Repeated urine Fetal growth Ultrasound measurement Birth outcomes |
| url | http://www.sciencedirect.com/science/article/pii/S0160412024001703 |
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