Dependence of Working Memory on Coordinated Activity Across Brain Areas
Neural signatures of working memory (WM) have been reported in numerous brain areas, suggesting a distributed neural substrate for memory maintenance. In the current manuscript we provide an updated review of the literature focusing on intracranial neurophysiological recordings during WM in primates...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-01-01
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| Series: | Frontiers in Systems Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnsys.2021.787316/full |
| _version_ | 1818754905154781184 |
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| author | Ehsan Rezayat Kelsey Clark Mohammad-Reza A. Dehaqani Mohammad-Reza A. Dehaqani Behrad Noudoost |
| author_facet | Ehsan Rezayat Kelsey Clark Mohammad-Reza A. Dehaqani Mohammad-Reza A. Dehaqani Behrad Noudoost |
| author_sort | Ehsan Rezayat |
| collection | DOAJ |
| description | Neural signatures of working memory (WM) have been reported in numerous brain areas, suggesting a distributed neural substrate for memory maintenance. In the current manuscript we provide an updated review of the literature focusing on intracranial neurophysiological recordings during WM in primates. Such signatures of WM include changes in firing rate or local oscillatory power within an area, along with measures of coordinated activity between areas based on synchronization between oscillations. In comparing the ability of various neural signatures in any brain area to predict behavioral performance, we observe that synchrony between areas is more frequently and robustly correlated with WM performance than any of the within-area neural signatures. We further review the evidence for alteration of inter-areal synchrony in brain disorders, consistent with an important role for such synchrony during behavior. Additionally, results of causal studies indicate that manipulating synchrony across areas is especially effective at influencing WM task performance. Each of these lines of research supports the critical role of inter-areal synchrony in WM. Finally, we propose a framework for interactions between prefrontal and sensory areas during WM, incorporating a range of experimental findings and offering an explanation for the observed link between intra-areal measures and WM performance. |
| first_indexed | 2024-12-18T05:30:40Z |
| format | Article |
| id | doaj.art-1054c656ab1b4eae877bf1a6fe70e4a7 |
| institution | Directory Open Access Journal |
| issn | 1662-5137 |
| language | English |
| last_indexed | 2024-12-18T05:30:40Z |
| publishDate | 2022-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Systems Neuroscience |
| spelling | doaj.art-1054c656ab1b4eae877bf1a6fe70e4a72022-12-21T21:19:26ZengFrontiers Media S.A.Frontiers in Systems Neuroscience1662-51372022-01-011510.3389/fnsys.2021.787316787316Dependence of Working Memory on Coordinated Activity Across Brain AreasEhsan Rezayat0Kelsey Clark1Mohammad-Reza A. Dehaqani2Mohammad-Reza A. Dehaqani3Behrad Noudoost4School of Cognitive Sciences, Institute for Research in Fundamental Sciences (IPM), Tehran, IranDepartment of Ophthalmology and Visual Sciences, University of Utah, Salt Lake City, UT, United StatesSchool of Cognitive Sciences, Institute for Research in Fundamental Sciences (IPM), Tehran, IranCognitive Systems Laboratory, Control and Intelligent Processing Center of Excellence (CIPCE), School of Electrical and Computer Engineering, College of Engineering, University of Tehran, Tehran, IranDepartment of Ophthalmology and Visual Sciences, University of Utah, Salt Lake City, UT, United StatesNeural signatures of working memory (WM) have been reported in numerous brain areas, suggesting a distributed neural substrate for memory maintenance. In the current manuscript we provide an updated review of the literature focusing on intracranial neurophysiological recordings during WM in primates. Such signatures of WM include changes in firing rate or local oscillatory power within an area, along with measures of coordinated activity between areas based on synchronization between oscillations. In comparing the ability of various neural signatures in any brain area to predict behavioral performance, we observe that synchrony between areas is more frequently and robustly correlated with WM performance than any of the within-area neural signatures. We further review the evidence for alteration of inter-areal synchrony in brain disorders, consistent with an important role for such synchrony during behavior. Additionally, results of causal studies indicate that manipulating synchrony across areas is especially effective at influencing WM task performance. Each of these lines of research supports the critical role of inter-areal synchrony in WM. Finally, we propose a framework for interactions between prefrontal and sensory areas during WM, incorporating a range of experimental findings and offering an explanation for the observed link between intra-areal measures and WM performance.https://www.frontiersin.org/articles/10.3389/fnsys.2021.787316/fullworking memorysynchronyoscillationbrain disorderscausal manipulation |
| spellingShingle | Ehsan Rezayat Kelsey Clark Mohammad-Reza A. Dehaqani Mohammad-Reza A. Dehaqani Behrad Noudoost Dependence of Working Memory on Coordinated Activity Across Brain Areas Frontiers in Systems Neuroscience working memory synchrony oscillation brain disorders causal manipulation |
| title | Dependence of Working Memory on Coordinated Activity Across Brain Areas |
| title_full | Dependence of Working Memory on Coordinated Activity Across Brain Areas |
| title_fullStr | Dependence of Working Memory on Coordinated Activity Across Brain Areas |
| title_full_unstemmed | Dependence of Working Memory on Coordinated Activity Across Brain Areas |
| title_short | Dependence of Working Memory on Coordinated Activity Across Brain Areas |
| title_sort | dependence of working memory on coordinated activity across brain areas |
| topic | working memory synchrony oscillation brain disorders causal manipulation |
| url | https://www.frontiersin.org/articles/10.3389/fnsys.2021.787316/full |
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