Ameliorative Effect of Enhydra fluctuans on Liver Damage in Diabetic Rats
Diabetes mellitus and insulin resistance cause harm to the liver. In this study, ameliorative effect of Enhydra fluctuans on liver damage in alloxan-induced diabetic rats were examined. Thirty acclimatized male albino rats divided into six groups (n = 5). Normal rats were fed a standard diet (Gr...
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| Format: | Article |
| Language: | English |
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College of Pharmacy University of Baghdad
2023-12-01
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| Series: | Iraqi Journal of Pharmaceutical Sciences |
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| Online Access: | https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/2175 |
| _version_ | 1827394666114318336 |
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| author | Rina Delfita Djong Hon Tjong |
| author_facet | Rina Delfita Djong Hon Tjong |
| author_sort | Rina Delfita |
| collection | DOAJ |
| description |
Diabetes mellitus and insulin resistance cause harm to the liver. In this study, ameliorative effect of Enhydra fluctuans on liver damage in alloxan-induced diabetic rats were examined.
Thirty acclimatized male albino rats divided into six groups (n = 5). Normal rats were fed a standard diet (Group 1); diabetic rats were provided standard feed (Group 2); diabetic rats were fed standard feed and glibenclamide (Group 3); and diabetic rats were fed standard food and fractions of n-hexane E. fluctuans 57.03, 114.06, and 171.09 mg/kg, respectively (Group 4, 5 and 6). For 21 days, rats were fed the n-hexane fraction orally. On day 1 and day 21 of treatments, blood sugar levels were measured. The histophatology of the liver, serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvate transaminase (SGPT) level were estimated.
At a dosage of 57.03 mg/kg was substantially (p < 0.05) beneficial in decreasing blood sugar and SGOT. The n-hexane fraction of E. fluctuans ameliorated liver damage in diabetic rats and avoided diabetes complications, according to our findings. As a result, E. fluctuans has a considerable amount of potential as a novel diabetic therapy.
Keywords: Diabetes, Enhydra fluctuans, Insulin resistance, Liver cells regeneration.
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| first_indexed | 2024-03-08T18:17:17Z |
| format | Article |
| id | doaj.art-10553423e765473c9876d32b35bd469a |
| institution | Directory Open Access Journal |
| issn | 1683-3597 2521-3512 |
| language | English |
| last_indexed | 2024-03-08T18:17:17Z |
| publishDate | 2023-12-01 |
| publisher | College of Pharmacy University of Baghdad |
| record_format | Article |
| series | Iraqi Journal of Pharmaceutical Sciences |
| spelling | doaj.art-10553423e765473c9876d32b35bd469a2023-12-31T10:06:11ZengCollege of Pharmacy University of BaghdadIraqi Journal of Pharmaceutical Sciences1683-35972521-35122023-12-0132310.31351/vol32iss3pp128-133Ameliorative Effect of Enhydra fluctuans on Liver Damage in Diabetic RatsRina Delfita0Djong Hon Tjong1Universitas Islam Negeri (UIN) Mahmud Yunus BatusangkarDepartment of Biology, Faculty of Mathematics and Natural Science, Andalas University, West Sumatra, Indonesia Diabetes mellitus and insulin resistance cause harm to the liver. In this study, ameliorative effect of Enhydra fluctuans on liver damage in alloxan-induced diabetic rats were examined. Thirty acclimatized male albino rats divided into six groups (n = 5). Normal rats were fed a standard diet (Group 1); diabetic rats were provided standard feed (Group 2); diabetic rats were fed standard feed and glibenclamide (Group 3); and diabetic rats were fed standard food and fractions of n-hexane E. fluctuans 57.03, 114.06, and 171.09 mg/kg, respectively (Group 4, 5 and 6). For 21 days, rats were fed the n-hexane fraction orally. On day 1 and day 21 of treatments, blood sugar levels were measured. The histophatology of the liver, serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvate transaminase (SGPT) level were estimated. At a dosage of 57.03 mg/kg was substantially (p < 0.05) beneficial in decreasing blood sugar and SGOT. The n-hexane fraction of E. fluctuans ameliorated liver damage in diabetic rats and avoided diabetes complications, according to our findings. As a result, E. fluctuans has a considerable amount of potential as a novel diabetic therapy. Keywords: Diabetes, Enhydra fluctuans, Insulin resistance, Liver cells regeneration. https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/2175DiabetesEnhydra fluctuansInsulin resistanceLiver cells regeneration |
| spellingShingle | Rina Delfita Djong Hon Tjong Ameliorative Effect of Enhydra fluctuans on Liver Damage in Diabetic Rats Iraqi Journal of Pharmaceutical Sciences Diabetes Enhydra fluctuans Insulin resistance Liver cells regeneration |
| title | Ameliorative Effect of Enhydra fluctuans on Liver Damage in Diabetic Rats |
| title_full | Ameliorative Effect of Enhydra fluctuans on Liver Damage in Diabetic Rats |
| title_fullStr | Ameliorative Effect of Enhydra fluctuans on Liver Damage in Diabetic Rats |
| title_full_unstemmed | Ameliorative Effect of Enhydra fluctuans on Liver Damage in Diabetic Rats |
| title_short | Ameliorative Effect of Enhydra fluctuans on Liver Damage in Diabetic Rats |
| title_sort | ameliorative effect of enhydra fluctuans on liver damage in diabetic rats |
| topic | Diabetes Enhydra fluctuans Insulin resistance Liver cells regeneration |
| url | https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/2175 |
| work_keys_str_mv | AT rinadelfita ameliorativeeffectofenhydrafluctuansonliverdamageindiabeticrats AT djonghontjong ameliorativeeffectofenhydrafluctuansonliverdamageindiabeticrats |