FoxA and LIPG endothelial lipase control the uptake of extracellular lipids for breast cancer growth
Deregulation of lipid metabolism in cancer cells is critical to the maintenance of certain malignant features. Here, the authors show that the proliferation of breast cancer cells depends upon the extracellular activity of the endothelial lipase enzyme LIPG whose expression is regulated by the FoxA...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2016-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms11199 |
| _version_ | 1818996732984295424 |
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| author | Felipe Slebe Federico Rojo Maria Vinaixa Mar García-Rocha Giorgia Testoni Marc Guiu Evarist Planet Sara Samino Enrique J. Arenas Antoni Beltran Ana Rovira Ana Lluch Xavier Salvatella Oscar Yanes Joan Albanell Joan J. Guinovart Roger R. Gomis |
| author_facet | Felipe Slebe Federico Rojo Maria Vinaixa Mar García-Rocha Giorgia Testoni Marc Guiu Evarist Planet Sara Samino Enrique J. Arenas Antoni Beltran Ana Rovira Ana Lluch Xavier Salvatella Oscar Yanes Joan Albanell Joan J. Guinovart Roger R. Gomis |
| author_sort | Felipe Slebe |
| collection | DOAJ |
| description | Deregulation of lipid metabolism in cancer cells is critical to the maintenance of certain malignant features. Here, the authors show that the proliferation of breast cancer cells depends upon the extracellular activity of the endothelial lipase enzyme LIPG whose expression is regulated by the FoxA family of transcription factors. |
| first_indexed | 2024-12-20T21:34:25Z |
| format | Article |
| id | doaj.art-10556d75bea04703ad93a919ca77d8fc |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T21:34:25Z |
| publishDate | 2016-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-10556d75bea04703ad93a919ca77d8fc2022-12-21T19:25:58ZengNature PortfolioNature Communications2041-17232016-04-017111110.1038/ncomms11199FoxA and LIPG endothelial lipase control the uptake of extracellular lipids for breast cancer growthFelipe Slebe0Federico Rojo1Maria Vinaixa2Mar García-Rocha3Giorgia Testoni4Marc Guiu5Evarist Planet6Sara Samino7Enrique J. Arenas8Antoni Beltran9Ana Rovira10Ana Lluch11Xavier Salvatella12Oscar Yanes13Joan Albanell14Joan J. Guinovart15Roger R. Gomis16Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and TechnologyCancer Research Programme, IMIM (Hospital del Mar Medical Research Institute)Centre for Omic Sciences, Universitat Rovira i VirgiliInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and TechnologyInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and TechnologyInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and TechnologyInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and TechnologyCentre for Omic Sciences, Universitat Rovira i VirgiliInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and TechnologyCentre for Omic Sciences, Universitat Rovira i VirgiliCancer Research Programme, IMIM (Hospital del Mar Medical Research Institute)Medical Oncology Service, Hospital ClinicoInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and TechnologyCentre for Omic Sciences, Universitat Rovira i VirgiliCancer Research Programme, IMIM (Hospital del Mar Medical Research Institute)Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and TechnologyInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and TechnologyDeregulation of lipid metabolism in cancer cells is critical to the maintenance of certain malignant features. Here, the authors show that the proliferation of breast cancer cells depends upon the extracellular activity of the endothelial lipase enzyme LIPG whose expression is regulated by the FoxA family of transcription factors.https://doi.org/10.1038/ncomms11199 |
| spellingShingle | Felipe Slebe Federico Rojo Maria Vinaixa Mar García-Rocha Giorgia Testoni Marc Guiu Evarist Planet Sara Samino Enrique J. Arenas Antoni Beltran Ana Rovira Ana Lluch Xavier Salvatella Oscar Yanes Joan Albanell Joan J. Guinovart Roger R. Gomis FoxA and LIPG endothelial lipase control the uptake of extracellular lipids for breast cancer growth Nature Communications |
| title | FoxA and LIPG endothelial lipase control the uptake of extracellular lipids for breast cancer growth |
| title_full | FoxA and LIPG endothelial lipase control the uptake of extracellular lipids for breast cancer growth |
| title_fullStr | FoxA and LIPG endothelial lipase control the uptake of extracellular lipids for breast cancer growth |
| title_full_unstemmed | FoxA and LIPG endothelial lipase control the uptake of extracellular lipids for breast cancer growth |
| title_short | FoxA and LIPG endothelial lipase control the uptake of extracellular lipids for breast cancer growth |
| title_sort | foxa and lipg endothelial lipase control the uptake of extracellular lipids for breast cancer growth |
| url | https://doi.org/10.1038/ncomms11199 |
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