Genome-wide binding and transcriptome analysis of human farnesoid X receptor in primary human hepatocytes.

Genome-wide binding and transcriptome analysis of human farnesoid X receptor in primary human hepatocytes.

Farnesoid X receptor (FXR, NR1H4) is a ligand-activated transcription factor, belonging to the nuclear receptor superfamily. FXR is highly expressed in the liver and is essential in regulating bile acid homeostasis. FXR deficiency is implicated in numerous liver diseases and mice with modulation of...

Full description

Bibliographic Details
Main Authors: Le Zhan, Hui-Xin Liu, Yaping Fang, Bo Kong, Yuqi He, Xiao-Bo Zhong, Jianwen Fang, Yu-Jui Yvonne Wan, Grace L Guo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4157742?pdf=render

Similar Items

Similar Items