WD40-repeat proteins in plant cell wall formation: current evidence and research prospects
The metabolic complexity of living organisms relies on supramolecular protein structures which ensure vital processes, such as signal transduction, transcription, translation and cell wall synthesis. In eukaryotes WD40-repeat (WDR) proteins often function as molecular hubs mediating supramolecular i...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-12-01
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| Series: | Frontiers in Plant Science |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fpls.2015.01112/full |
| _version_ | 1811263075631759360 |
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| author | Gea eGuerriero Jean-Francois eHausman Inés eEzcurra |
| author_facet | Gea eGuerriero Jean-Francois eHausman Inés eEzcurra |
| author_sort | Gea eGuerriero |
| collection | DOAJ |
| description | The metabolic complexity of living organisms relies on supramolecular protein structures which ensure vital processes, such as signal transduction, transcription, translation and cell wall synthesis. In eukaryotes WD40-repeat (WDR) proteins often function as molecular hubs mediating supramolecular interactions. WDR proteins may display a variety of interacting partners and participate in the assembly of complexes involved in distinct cellular functions. In plants, the formation of lignocellulosic biomass involves extensive synthesis of cell wall polysaccharides, a process that requires the assembly of large transmembrane enzyme complexes, intensive vesicle trafficking, interactions with the cytoskeleton, and coordinated gene expression. Because of their function as supramolecular hubs, WDR proteins could participate in each or any of these steps, although to date only few WDR proteins have been linked to the cell wall by experimental evidence. Nevertheless, several potential cell wall-related WDR proteins were recently identified using in silico aproaches, such as analyses of co-expression, interactome and conserved gene neighbourhood. Notably, some WDR genes are frequently genomic neighbours of genes coding for GT2-family polysaccharide synthases in eukaryotes, and this WDR-GT2 collinear microsynteny is detected in diverse taxa. In angiosperms, two WDR genes are collinear to cellulose synthase genes, CESAs, whereas in ascomycetous fungi several WDR genes are adjacent to chitin synthase genes, chs. In this Perspective we summarize and discuss experimental and in silico studies on the possible involvement of WDR proteins in plant cell wall formation. The prospects of biotechnological engineering for enhanced biomass production are discussed. |
| first_indexed | 2024-04-12T19:39:27Z |
| format | Article |
| id | doaj.art-10572a919c9247efa3c80d957a1f58ee |
| institution | Directory Open Access Journal |
| issn | 1664-462X |
| language | English |
| last_indexed | 2024-04-12T19:39:27Z |
| publishDate | 2015-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Plant Science |
| spelling | doaj.art-10572a919c9247efa3c80d957a1f58ee2022-12-22T03:19:08ZengFrontiers Media S.A.Frontiers in Plant Science1664-462X2015-12-01610.3389/fpls.2015.01112170430WD40-repeat proteins in plant cell wall formation: current evidence and research prospectsGea eGuerriero0Jean-Francois eHausman1Inés eEzcurra2Luxembourg Institute of Science and Technology-LISTLuxembourg Institute of Science and Technology-LISTRoyal Institute of Technology-KTHThe metabolic complexity of living organisms relies on supramolecular protein structures which ensure vital processes, such as signal transduction, transcription, translation and cell wall synthesis. In eukaryotes WD40-repeat (WDR) proteins often function as molecular hubs mediating supramolecular interactions. WDR proteins may display a variety of interacting partners and participate in the assembly of complexes involved in distinct cellular functions. In plants, the formation of lignocellulosic biomass involves extensive synthesis of cell wall polysaccharides, a process that requires the assembly of large transmembrane enzyme complexes, intensive vesicle trafficking, interactions with the cytoskeleton, and coordinated gene expression. Because of their function as supramolecular hubs, WDR proteins could participate in each or any of these steps, although to date only few WDR proteins have been linked to the cell wall by experimental evidence. Nevertheless, several potential cell wall-related WDR proteins were recently identified using in silico aproaches, such as analyses of co-expression, interactome and conserved gene neighbourhood. Notably, some WDR genes are frequently genomic neighbours of genes coding for GT2-family polysaccharide synthases in eukaryotes, and this WDR-GT2 collinear microsynteny is detected in diverse taxa. In angiosperms, two WDR genes are collinear to cellulose synthase genes, CESAs, whereas in ascomycetous fungi several WDR genes are adjacent to chitin synthase genes, chs. In this Perspective we summarize and discuss experimental and in silico studies on the possible involvement of WDR proteins in plant cell wall formation. The prospects of biotechnological engineering for enhanced biomass production are discussed.http://journal.frontiersin.org/Journal/10.3389/fpls.2015.01112/fullLignocelluloseplant cell wallprotein-protein interactionWDR proteinsGenomic collinearity |
| spellingShingle | Gea eGuerriero Jean-Francois eHausman Inés eEzcurra WD40-repeat proteins in plant cell wall formation: current evidence and research prospects Frontiers in Plant Science Lignocellulose plant cell wall protein-protein interaction WDR proteins Genomic collinearity |
| title | WD40-repeat proteins in plant cell wall formation: current evidence and research prospects |
| title_full | WD40-repeat proteins in plant cell wall formation: current evidence and research prospects |
| title_fullStr | WD40-repeat proteins in plant cell wall formation: current evidence and research prospects |
| title_full_unstemmed | WD40-repeat proteins in plant cell wall formation: current evidence and research prospects |
| title_short | WD40-repeat proteins in plant cell wall formation: current evidence and research prospects |
| title_sort | wd40 repeat proteins in plant cell wall formation current evidence and research prospects |
| topic | Lignocellulose plant cell wall protein-protein interaction WDR proteins Genomic collinearity |
| url | http://journal.frontiersin.org/Journal/10.3389/fpls.2015.01112/full |
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