Fluorinated Analogs of Malachite Green: Synthesis and Toxicity
A series of fluorinated analogs of malachite green (MG) have been synthesizedand their toxicity to Saccharomyces cerevisiae and a human ovarian epithelial cell lineexamined. The toxicity profiles were found to be different for these two species. Twoanalogs, one with 2,4-difluoro substitution and the...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2008-04-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1420-3049/13/4/986/ |
| _version_ | 1819170921212018688 |
|---|---|
| author | Bahram Parvin Jayeeta Banerjee Ahmed M. Awad Marit Nilsen-Hamilton Insik Jeon George A. Kraus |
| author_facet | Bahram Parvin Jayeeta Banerjee Ahmed M. Awad Marit Nilsen-Hamilton Insik Jeon George A. Kraus |
| author_sort | Bahram Parvin |
| collection | DOAJ |
| description | A series of fluorinated analogs of malachite green (MG) have been synthesizedand their toxicity to Saccharomyces cerevisiae and a human ovarian epithelial cell lineexamined. The toxicity profiles were found to be different for these two species. Twoanalogs, one with 2,4-difluoro substitution and the other with 2-fluoro substitution seem tobe the most promising analogs because they showed the lowest toxicity to the human cells. |
| first_indexed | 2024-12-22T19:43:04Z |
| format | Article |
| id | doaj.art-10574b0730244515bce4c531868f20eb |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-22T19:43:04Z |
| publishDate | 2008-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-10574b0730244515bce4c531868f20eb2022-12-21T18:14:46ZengMDPI AGMolecules1420-30492008-04-0113498699410.3390/molecules13040986Fluorinated Analogs of Malachite Green: Synthesis and ToxicityBahram ParvinJayeeta BanerjeeAhmed M. AwadMarit Nilsen-HamiltonInsik JeonGeorge A. KrausA series of fluorinated analogs of malachite green (MG) have been synthesizedand their toxicity to Saccharomyces cerevisiae and a human ovarian epithelial cell lineexamined. The toxicity profiles were found to be different for these two species. Twoanalogs, one with 2,4-difluoro substitution and the other with 2-fluoro substitution seem tobe the most promising analogs because they showed the lowest toxicity to the human cells.http://www.mdpi.com/1420-3049/13/4/986/Malachite GreenMalachite Green analogsBathochromic shiftToxicitySaccharomyces cerevisiaehuman ovarian epithelial cells. |
| spellingShingle | Bahram Parvin Jayeeta Banerjee Ahmed M. Awad Marit Nilsen-Hamilton Insik Jeon George A. Kraus Fluorinated Analogs of Malachite Green: Synthesis and Toxicity Molecules Malachite Green Malachite Green analogs Bathochromic shift Toxicity Saccharomyces cerevisiae human ovarian epithelial cells. |
| title | Fluorinated Analogs of Malachite Green: Synthesis and Toxicity |
| title_full | Fluorinated Analogs of Malachite Green: Synthesis and Toxicity |
| title_fullStr | Fluorinated Analogs of Malachite Green: Synthesis and Toxicity |
| title_full_unstemmed | Fluorinated Analogs of Malachite Green: Synthesis and Toxicity |
| title_short | Fluorinated Analogs of Malachite Green: Synthesis and Toxicity |
| title_sort | fluorinated analogs of malachite green synthesis and toxicity |
| topic | Malachite Green Malachite Green analogs Bathochromic shift Toxicity Saccharomyces cerevisiae human ovarian epithelial cells. |
| url | http://www.mdpi.com/1420-3049/13/4/986/ |
| work_keys_str_mv | AT bahramparvin fluorinatedanalogsofmalachitegreensynthesisandtoxicity AT jayeetabanerjee fluorinatedanalogsofmalachitegreensynthesisandtoxicity AT ahmedmawad fluorinatedanalogsofmalachitegreensynthesisandtoxicity AT maritnilsenhamilton fluorinatedanalogsofmalachitegreensynthesisandtoxicity AT insikjeon fluorinatedanalogsofmalachitegreensynthesisandtoxicity AT georgeakraus fluorinatedanalogsofmalachitegreensynthesisandtoxicity |