Prevalence and risk factors for diabetic peripheral neuropathy, neuropathic pain and foot ulceration in the Arabian Gulf region
Abstract Aims/Introduction This study determined the prevalence and risk factors for diabetic peripheral neuropathy (DPN), painful DPN and diabetic foot ulceration (DFU) in patients with type 2 diabetes in secondary healthcare in Qatar, Kuwait and the Kingdom of Saudi Arabia. Materials and Methods A...
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| Format: | Article |
| Language: | English |
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Wiley
2022-09-01
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| Series: | Journal of Diabetes Investigation |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jdi.13815 |
| _version_ | 1818471873030127616 |
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| author | Georgios Ponirakis Tarik Elhadd Ebaa Al Ozairi Imad Brema Subitha Chinnaiyan Etab Taghadom Jumana Al Kandari Rehab Al Wotayan Abdulla Al Ozairi Naji Aljohani Wael AlMistehi Nora Al Qahtani Shawana Khan Zeinab Dabbous Mashhood A Siddique Ioannis N Petropoulos Adnan Khan Hamad Almuhannadi Khaled AE Ashawesh Khaled M Dukhan Ziyad R Mahfoud Mahmoud A Zirie Amin Jayyousi Rayaz A Malik |
| author_facet | Georgios Ponirakis Tarik Elhadd Ebaa Al Ozairi Imad Brema Subitha Chinnaiyan Etab Taghadom Jumana Al Kandari Rehab Al Wotayan Abdulla Al Ozairi Naji Aljohani Wael AlMistehi Nora Al Qahtani Shawana Khan Zeinab Dabbous Mashhood A Siddique Ioannis N Petropoulos Adnan Khan Hamad Almuhannadi Khaled AE Ashawesh Khaled M Dukhan Ziyad R Mahfoud Mahmoud A Zirie Amin Jayyousi Rayaz A Malik |
| author_sort | Georgios Ponirakis |
| collection | DOAJ |
| description | Abstract Aims/Introduction This study determined the prevalence and risk factors for diabetic peripheral neuropathy (DPN), painful DPN and diabetic foot ulceration (DFU) in patients with type 2 diabetes in secondary healthcare in Qatar, Kuwait and the Kingdom of Saudi Arabia. Materials and Methods Adults aged 18–85 years with type 2 diabetes were randomly enrolled from secondary healthcare, and underwent clinical and metabolic assessment. DPN was evaluated using vibration perception threshold and neuropathic symptoms and painful Diabetic Peripheral Neuropathy was evaluated using the Douleur Neuropathique 4 questionnaire. Results A total of 3,021 individuals were recruited between June 2017 and May 2019. The prevalence of DPN was 33.3%, of whom 52.2% were at risk of DFU and 53.6% were undiagnosed. The prevalence of painful DPN was 43.3%, of whom 54.3% were undiagnosed. DFU was present in 2.9%. The adjusted odds ratios for DPN and painful DPN were higher with increasing diabetes duration, obesity, poor glycemic control and hyperlipidemia, and lower with greater physical activity. The adjusted odds ratio for DFU was higher with the presence of DPN, severe loss of vibration perception, hypertension and vitamin D deficiency. Conclusions This is the largest study to date from the Middle East showing a high prevalence of undiagnosed DPN, painful DPN and those at risk of DFU in patients with type 2 diabetes, and identifies their respective risk factors. |
| first_indexed | 2024-04-14T03:57:49Z |
| format | Article |
| id | doaj.art-10580d168cb947b3ac22d015e054b5ea |
| institution | Directory Open Access Journal |
| issn | 2040-1116 2040-1124 |
| language | English |
| last_indexed | 2024-04-14T03:57:49Z |
| publishDate | 2022-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Investigation |
| spelling | doaj.art-10580d168cb947b3ac22d015e054b5ea2022-12-22T02:13:42ZengWileyJournal of Diabetes Investigation2040-11162040-11242022-09-011391551155910.1111/jdi.13815Prevalence and risk factors for diabetic peripheral neuropathy, neuropathic pain and foot ulceration in the Arabian Gulf regionGeorgios Ponirakis0Tarik Elhadd1Ebaa Al Ozairi2Imad Brema3Subitha Chinnaiyan4Etab Taghadom5Jumana Al Kandari6Rehab Al Wotayan7Abdulla Al Ozairi8Naji Aljohani9Wael AlMistehi10Nora Al Qahtani11Shawana Khan12Zeinab Dabbous13Mashhood A Siddique14Ioannis N Petropoulos15Adnan Khan16Hamad Almuhannadi17Khaled AE Ashawesh18Khaled M Dukhan19Ziyad R Mahfoud20Mahmoud A Zirie21Amin Jayyousi22Rayaz A Malik23Department of Medicine Weill Cornell Medicine‐Qatar, Qatar Foundation Education City Doha QatarNational Diabetes Center Hamad General Hospital, Hamad Medical Corporation Doha QatarDepartment of Clinical Research Dasman Diabetes Institute Kuwait City KuwaitObesity Endocrine and Metabolism Center King Fahad Medical City Riyadh Saudi ArabiaNational Diabetes Center Hamad General Hospital, Hamad Medical Corporation Doha QatarDepartment of Clinical Research Dasman Diabetes Institute Kuwait City KuwaitDepartment of Clinical Research Dasman Diabetes Institute Kuwait City KuwaitDepartment of Clinical Research Dasman Diabetes Institute Kuwait City KuwaitDepartment of Clinical Research Dasman Diabetes Institute Kuwait City KuwaitObesity Endocrine and Metabolism Center King Fahad Medical City Riyadh Saudi ArabiaObesity Endocrine and Metabolism Center King Fahad Medical City Riyadh Saudi ArabiaObesity Endocrine and Metabolism Center King Fahad Medical City Riyadh Saudi ArabiaObesity Endocrine and Metabolism Center King Fahad Medical City Riyadh Saudi ArabiaNational Diabetes Center Hamad General Hospital, Hamad Medical Corporation Doha QatarNational Diabetes Center Hamad General Hospital, Hamad Medical Corporation Doha QatarDepartment of Medicine Weill Cornell Medicine‐Qatar, Qatar Foundation Education City Doha QatarDepartment of Medicine Weill Cornell Medicine‐Qatar, Qatar Foundation Education City Doha QatarNational Diabetes Center Hamad General Hospital, Hamad Medical Corporation Doha QatarNational Diabetes Center Al‐Wakra Hospital, Hamad Medical Corporation Doha QatarNational Diabetes Center Al‐Wakra Hospital, Hamad Medical Corporation Doha QatarDepartment of Medicine Weill Cornell Medicine‐Qatar, Qatar Foundation Education City Doha QatarNational Diabetes Center Hamad General Hospital, Hamad Medical Corporation Doha QatarNational Diabetes Center Hamad General Hospital, Hamad Medical Corporation Doha QatarDepartment of Medicine Weill Cornell Medicine‐Qatar, Qatar Foundation Education City Doha QatarAbstract Aims/Introduction This study determined the prevalence and risk factors for diabetic peripheral neuropathy (DPN), painful DPN and diabetic foot ulceration (DFU) in patients with type 2 diabetes in secondary healthcare in Qatar, Kuwait and the Kingdom of Saudi Arabia. Materials and Methods Adults aged 18–85 years with type 2 diabetes were randomly enrolled from secondary healthcare, and underwent clinical and metabolic assessment. DPN was evaluated using vibration perception threshold and neuropathic symptoms and painful Diabetic Peripheral Neuropathy was evaluated using the Douleur Neuropathique 4 questionnaire. Results A total of 3,021 individuals were recruited between June 2017 and May 2019. The prevalence of DPN was 33.3%, of whom 52.2% were at risk of DFU and 53.6% were undiagnosed. The prevalence of painful DPN was 43.3%, of whom 54.3% were undiagnosed. DFU was present in 2.9%. The adjusted odds ratios for DPN and painful DPN were higher with increasing diabetes duration, obesity, poor glycemic control and hyperlipidemia, and lower with greater physical activity. The adjusted odds ratio for DFU was higher with the presence of DPN, severe loss of vibration perception, hypertension and vitamin D deficiency. Conclusions This is the largest study to date from the Middle East showing a high prevalence of undiagnosed DPN, painful DPN and those at risk of DFU in patients with type 2 diabetes, and identifies their respective risk factors.https://doi.org/10.1111/jdi.13815Diabetic foot ulcerationDiabetic peripheral neuropathyPainful diabetic peripheral neuropathy |
| spellingShingle | Georgios Ponirakis Tarik Elhadd Ebaa Al Ozairi Imad Brema Subitha Chinnaiyan Etab Taghadom Jumana Al Kandari Rehab Al Wotayan Abdulla Al Ozairi Naji Aljohani Wael AlMistehi Nora Al Qahtani Shawana Khan Zeinab Dabbous Mashhood A Siddique Ioannis N Petropoulos Adnan Khan Hamad Almuhannadi Khaled AE Ashawesh Khaled M Dukhan Ziyad R Mahfoud Mahmoud A Zirie Amin Jayyousi Rayaz A Malik Prevalence and risk factors for diabetic peripheral neuropathy, neuropathic pain and foot ulceration in the Arabian Gulf region Journal of Diabetes Investigation Diabetic foot ulceration Diabetic peripheral neuropathy Painful diabetic peripheral neuropathy |
| title | Prevalence and risk factors for diabetic peripheral neuropathy, neuropathic pain and foot ulceration in the Arabian Gulf region |
| title_full | Prevalence and risk factors for diabetic peripheral neuropathy, neuropathic pain and foot ulceration in the Arabian Gulf region |
| title_fullStr | Prevalence and risk factors for diabetic peripheral neuropathy, neuropathic pain and foot ulceration in the Arabian Gulf region |
| title_full_unstemmed | Prevalence and risk factors for diabetic peripheral neuropathy, neuropathic pain and foot ulceration in the Arabian Gulf region |
| title_short | Prevalence and risk factors for diabetic peripheral neuropathy, neuropathic pain and foot ulceration in the Arabian Gulf region |
| title_sort | prevalence and risk factors for diabetic peripheral neuropathy neuropathic pain and foot ulceration in the arabian gulf region |
| topic | Diabetic foot ulceration Diabetic peripheral neuropathy Painful diabetic peripheral neuropathy |
| url | https://doi.org/10.1111/jdi.13815 |
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