Lifestyle habits to prevent the development of benign prostatic hyperplasia: Analysis of Japanese nationwide datasets
Objectives: Benign prostatic hyperplasia (BPH) refers to nonmalignant hyperplasia of prostate tissue, which causes lower urinary tract symptoms and has become a global public health concern in the aging population. The purpose of this study is to identify modifiable factors, which would prevent or d...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Prostate International |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2287888222000381 |
| _version_ | 1797705102204600320 |
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| author | Yukinori Nagakura Maya Hayashi Shunichi Kajioka |
| author_facet | Yukinori Nagakura Maya Hayashi Shunichi Kajioka |
| author_sort | Yukinori Nagakura |
| collection | DOAJ |
| description | Objectives: Benign prostatic hyperplasia (BPH) refers to nonmalignant hyperplasia of prostate tissue, which causes lower urinary tract symptoms and has become a global public health concern in the aging population. The purpose of this study is to identify modifiable factors, which would prevent or delay BPH development. Methods: The association between BPH marker drugs and climate-, socioeconomic-, health condition-, and lifestyle habits-related variables was investigated by analyzing nationwide datasets which were collected in 2018, aggregated by prefecture (administrative unit), and published by Japanese ministries. Uroselective α1 receptor blockers and dutasteride were used as marker drugs referring to BPH prevalence. Correlation analysis, multiple linear regression analysis, and binomial logistic regression analysis were conducted with 47 Japanese prefectures as the unit. Results: The variables which showed |r| > 0.5 by correlation analysis were exercise habits (r = −0.5696), smoking habits (r = 0.6116), and daily drinking (r = 0.6001) for uroselective α1 receptor blockers, and antihypertensive medication (r = 0.5971), smoking habits (r = 0.6598), a small amount of drinking (r = −0.5292), and serum alanine aminotransferase (r = 0.6814) for dutasteride. Multiple linear regression equations were constructed by including these variables (R2 = 0.5453 for uroselective α1 receptor blockers and R2 = 0.5673 for dutasteride). Binomial logistic regression analysis found a significant association between climate in the resident area and BPH development. Conclusion: This ecological study, analyzing Japanese nationwide datasets, demonstrates that healthy lifestyle habits, especially avoidance of smoking, implementation of exercise in daily life, and a small amount of alcohol consumption, are important to prevent or delay BPH development. High blood pressure and high serum alanine aminotransferase are suggested as risk factors of BPH development. |
| first_indexed | 2024-03-12T05:32:09Z |
| format | Article |
| id | doaj.art-10584e117e194e158cf0824ed56b72ee |
| institution | Directory Open Access Journal |
| issn | 2287-8882 |
| language | English |
| last_indexed | 2024-03-12T05:32:09Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Prostate International |
| spelling | doaj.art-10584e117e194e158cf0824ed56b72ee2023-09-03T06:49:42ZengElsevierProstate International2287-88822022-12-01104200206Lifestyle habits to prevent the development of benign prostatic hyperplasia: Analysis of Japanese nationwide datasetsYukinori Nagakura0Maya Hayashi1Shunichi Kajioka2School of Pharmacy at Fukuoka, International University of Health and Welfare, 137-1, Enokizu, Okawa-city, Fukuoka 831-8501, Japan; Corresponding author. School of Pharmacy at Fukuoka, International University of Health and Welfare, 137-1, Enokizu, Okawa-city, Fukuoka 831-8501, Japan.The Ministry of Justice in Japan, Correction Bureau, 1-1-1 Kasumigaseki Chiyoda-ku, Tokyo 100-8977, JapanSchool of Pharmacy at Fukuoka, International University of Health and Welfare, 137-1, Enokizu, Okawa-city, Fukuoka 831-8501, JapanObjectives: Benign prostatic hyperplasia (BPH) refers to nonmalignant hyperplasia of prostate tissue, which causes lower urinary tract symptoms and has become a global public health concern in the aging population. The purpose of this study is to identify modifiable factors, which would prevent or delay BPH development. Methods: The association between BPH marker drugs and climate-, socioeconomic-, health condition-, and lifestyle habits-related variables was investigated by analyzing nationwide datasets which were collected in 2018, aggregated by prefecture (administrative unit), and published by Japanese ministries. Uroselective α1 receptor blockers and dutasteride were used as marker drugs referring to BPH prevalence. Correlation analysis, multiple linear regression analysis, and binomial logistic regression analysis were conducted with 47 Japanese prefectures as the unit. Results: The variables which showed |r| > 0.5 by correlation analysis were exercise habits (r = −0.5696), smoking habits (r = 0.6116), and daily drinking (r = 0.6001) for uroselective α1 receptor blockers, and antihypertensive medication (r = 0.5971), smoking habits (r = 0.6598), a small amount of drinking (r = −0.5292), and serum alanine aminotransferase (r = 0.6814) for dutasteride. Multiple linear regression equations were constructed by including these variables (R2 = 0.5453 for uroselective α1 receptor blockers and R2 = 0.5673 for dutasteride). Binomial logistic regression analysis found a significant association between climate in the resident area and BPH development. Conclusion: This ecological study, analyzing Japanese nationwide datasets, demonstrates that healthy lifestyle habits, especially avoidance of smoking, implementation of exercise in daily life, and a small amount of alcohol consumption, are important to prevent or delay BPH development. High blood pressure and high serum alanine aminotransferase are suggested as risk factors of BPH development.http://www.sciencedirect.com/science/article/pii/S2287888222000381Benign prostatic hyperplasiaClimateHealth conditionLifestyle habitsSocioeconomic variable |
| spellingShingle | Yukinori Nagakura Maya Hayashi Shunichi Kajioka Lifestyle habits to prevent the development of benign prostatic hyperplasia: Analysis of Japanese nationwide datasets Prostate International Benign prostatic hyperplasia Climate Health condition Lifestyle habits Socioeconomic variable |
| title | Lifestyle habits to prevent the development of benign prostatic hyperplasia: Analysis of Japanese nationwide datasets |
| title_full | Lifestyle habits to prevent the development of benign prostatic hyperplasia: Analysis of Japanese nationwide datasets |
| title_fullStr | Lifestyle habits to prevent the development of benign prostatic hyperplasia: Analysis of Japanese nationwide datasets |
| title_full_unstemmed | Lifestyle habits to prevent the development of benign prostatic hyperplasia: Analysis of Japanese nationwide datasets |
| title_short | Lifestyle habits to prevent the development of benign prostatic hyperplasia: Analysis of Japanese nationwide datasets |
| title_sort | lifestyle habits to prevent the development of benign prostatic hyperplasia analysis of japanese nationwide datasets |
| topic | Benign prostatic hyperplasia Climate Health condition Lifestyle habits Socioeconomic variable |
| url | http://www.sciencedirect.com/science/article/pii/S2287888222000381 |
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