In Vivo Models of HDV Infection: Is Humanizing NTCP Enough?
The discovery of sodium taurocholate co-transporting polypeptide (NTCP) as a hepatitis B (HBV) and delta virus (HDV) entry receptor has encouraged the development of new animal models of infection. This review provides an overview of the different in vivo models that are currently available to study...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Viruses |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4915/13/4/588 |
| _version_ | 1827696329387671552 |
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| author | Katja Giersch Maura Dandri |
| author_facet | Katja Giersch Maura Dandri |
| author_sort | Katja Giersch |
| collection | DOAJ |
| description | The discovery of sodium taurocholate co-transporting polypeptide (NTCP) as a hepatitis B (HBV) and delta virus (HDV) entry receptor has encouraged the development of new animal models of infection. This review provides an overview of the different in vivo models that are currently available to study HDV either in the absence or presence of HBV. By presenting new advances and remaining drawbacks, we will discuss human host factors which, in addition to NTCP, need to be investigated or identified to enable a persistent HDV infection in murine hepatocytes. Detailed knowledge on species-specific factors involved in HDV persistence also shall contribute to the development of therapeutic strategies. |
| first_indexed | 2024-03-10T12:45:09Z |
| format | Article |
| id | doaj.art-10589d8f17ea4f768497204a2c09f49c |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T12:45:09Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-10589d8f17ea4f768497204a2c09f49c2023-11-21T13:31:30ZengMDPI AGViruses1999-49152021-03-0113458810.3390/v13040588In Vivo Models of HDV Infection: Is Humanizing NTCP Enough?Katja Giersch0Maura Dandri1Department of Internal Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, GermanyDepartment of Internal Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, GermanyThe discovery of sodium taurocholate co-transporting polypeptide (NTCP) as a hepatitis B (HBV) and delta virus (HDV) entry receptor has encouraged the development of new animal models of infection. This review provides an overview of the different in vivo models that are currently available to study HDV either in the absence or presence of HBV. By presenting new advances and remaining drawbacks, we will discuss human host factors which, in addition to NTCP, need to be investigated or identified to enable a persistent HDV infection in murine hepatocytes. Detailed knowledge on species-specific factors involved in HDV persistence also shall contribute to the development of therapeutic strategies.https://www.mdpi.com/1999-4915/13/4/588mouse modelinfectionhepatitis deltaNTCPhuman liver chimeric miceHDV persistence |
| spellingShingle | Katja Giersch Maura Dandri In Vivo Models of HDV Infection: Is Humanizing NTCP Enough? Viruses mouse model infection hepatitis delta NTCP human liver chimeric mice HDV persistence |
| title | In Vivo Models of HDV Infection: Is Humanizing NTCP Enough? |
| title_full | In Vivo Models of HDV Infection: Is Humanizing NTCP Enough? |
| title_fullStr | In Vivo Models of HDV Infection: Is Humanizing NTCP Enough? |
| title_full_unstemmed | In Vivo Models of HDV Infection: Is Humanizing NTCP Enough? |
| title_short | In Vivo Models of HDV Infection: Is Humanizing NTCP Enough? |
| title_sort | in vivo models of hdv infection is humanizing ntcp enough |
| topic | mouse model infection hepatitis delta NTCP human liver chimeric mice HDV persistence |
| url | https://www.mdpi.com/1999-4915/13/4/588 |
| work_keys_str_mv | AT katjagiersch invivomodelsofhdvinfectionishumanizingntcpenough AT mauradandri invivomodelsofhdvinfectionishumanizingntcpenough |