Prepontine cisternal routine for intrathecal targeted drug delivery in craniofacial cancer pain treatment: technical note
Intrathecal targeted drug delivery provides effective relief for cancer-related pain. However, its validation in management of craniofacial pain remains much less widely practiced, mainly due to the localized diffusion of analgesic agent with current approach. Here, we report our experience of prepo...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2022-12-01
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| Series: | Drug Delivery |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/10717544.2022.2134507 |
| _version_ | 1797985874523193344 |
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| author | Haocheng Zhou Dong Huang Dingquan Zou Junjiao Hu Xinning Li Yaping Wang |
| author_facet | Haocheng Zhou Dong Huang Dingquan Zou Junjiao Hu Xinning Li Yaping Wang |
| author_sort | Haocheng Zhou |
| collection | DOAJ |
| description | Intrathecal targeted drug delivery provides effective relief for cancer-related pain. However, its validation in management of craniofacial pain remains much less widely practiced, mainly due to the localized diffusion of analgesic agent with current approach. Here, we report our experience of prepontine cisternal routine for placement and implantation of intrathecal targeted drug delivery in two cases of cancer-related craniofacial pain. Lumbar cannulation was applied and the intrathecal catheter tip was positioned at the prepontine cistern under fluoroscopic guidance during the surgical implantation. Postoperative imaging confirmed that the catheter tip was successfully placed in the prepontine cisternal space. Satisfactory control of pain was achieved after intrathecal therapy, with significant reduction of background and breakthrough cancer pain. None obvious complications were observed in this study. Thus, our novel intrathecal routine may provide an alternative option for craniofacial pain caused by tumor, who were insufficiently treated by oral analgesic agents. |
| first_indexed | 2024-04-11T07:23:56Z |
| format | Article |
| id | doaj.art-1058b75898c24b83845714b93f6f95b2 |
| institution | Directory Open Access Journal |
| issn | 1071-7544 1521-0464 |
| language | English |
| last_indexed | 2024-04-11T07:23:56Z |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Drug Delivery |
| spelling | doaj.art-1058b75898c24b83845714b93f6f95b22022-12-22T04:37:07ZengTaylor & Francis GroupDrug Delivery1071-75441521-04642022-12-012913213321710.1080/10717544.2022.2134507Prepontine cisternal routine for intrathecal targeted drug delivery in craniofacial cancer pain treatment: technical noteHaocheng Zhou0Dong Huang1Dingquan Zou2Junjiao Hu3Xinning Li4Yaping Wang5Department of Pain Management and Anesthesiology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, ChinaDepartment of Pain, The Third Xiangya Hospital and Institute of Pain Medicine, Central South University, Changsha, Hunan, ChinaDepartment of Pain Management and Anesthesiology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, ChinaDepartment of Radiology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, ChinaDepartment of Pain Management and Anesthesiology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, ChinaDepartment of Pain Management and Anesthesiology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, ChinaIntrathecal targeted drug delivery provides effective relief for cancer-related pain. However, its validation in management of craniofacial pain remains much less widely practiced, mainly due to the localized diffusion of analgesic agent with current approach. Here, we report our experience of prepontine cisternal routine for placement and implantation of intrathecal targeted drug delivery in two cases of cancer-related craniofacial pain. Lumbar cannulation was applied and the intrathecal catheter tip was positioned at the prepontine cistern under fluoroscopic guidance during the surgical implantation. Postoperative imaging confirmed that the catheter tip was successfully placed in the prepontine cisternal space. Satisfactory control of pain was achieved after intrathecal therapy, with significant reduction of background and breakthrough cancer pain. None obvious complications were observed in this study. Thus, our novel intrathecal routine may provide an alternative option for craniofacial pain caused by tumor, who were insufficiently treated by oral analgesic agents.https://www.tandfonline.com/doi/10.1080/10717544.2022.2134507Prepontine cisternalintrathecalcraniofacialcancer paintechnical note |
| spellingShingle | Haocheng Zhou Dong Huang Dingquan Zou Junjiao Hu Xinning Li Yaping Wang Prepontine cisternal routine for intrathecal targeted drug delivery in craniofacial cancer pain treatment: technical note Drug Delivery Prepontine cisternal intrathecal craniofacial cancer pain technical note |
| title | Prepontine cisternal routine for intrathecal targeted drug delivery in craniofacial cancer pain treatment: technical note |
| title_full | Prepontine cisternal routine for intrathecal targeted drug delivery in craniofacial cancer pain treatment: technical note |
| title_fullStr | Prepontine cisternal routine for intrathecal targeted drug delivery in craniofacial cancer pain treatment: technical note |
| title_full_unstemmed | Prepontine cisternal routine for intrathecal targeted drug delivery in craniofacial cancer pain treatment: technical note |
| title_short | Prepontine cisternal routine for intrathecal targeted drug delivery in craniofacial cancer pain treatment: technical note |
| title_sort | prepontine cisternal routine for intrathecal targeted drug delivery in craniofacial cancer pain treatment technical note |
| topic | Prepontine cisternal intrathecal craniofacial cancer pain technical note |
| url | https://www.tandfonline.com/doi/10.1080/10717544.2022.2134507 |
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