Fabrication of quantum dot-immobilized Y2O3 microspheres with effective photoluminescence for cancer radioembolization therapy
ABSTRACTMicrospheres composed of Y-containing materials are effective agents for cancer radioembolization therapy using β-rays. The distribution and dynamics of these microspheres in tissues can be easily determined by providing the microspheres with an imaging function. In addition, the use of quan...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Science and Technology of Advanced Materials |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/14686996.2024.2331412 |
| _version_ | 1797229424953786368 |
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| author | Toshiki Miyazaki Takumi Wakayama Masaru Oda Masakazu Kawashita |
| author_facet | Toshiki Miyazaki Takumi Wakayama Masaru Oda Masakazu Kawashita |
| author_sort | Toshiki Miyazaki |
| collection | DOAJ |
| description | ABSTRACTMicrospheres composed of Y-containing materials are effective agents for cancer radioembolization therapy using β-rays. The distribution and dynamics of these microspheres in tissues can be easily determined by providing the microspheres with an imaging function. In addition, the use of quantum dots will enable the detection of microspheres at the individual particle level with high sensitivity. In this study, core – shell quantum dots were bound to chemically modified yttria microspheres under various conditions, and the effect of reaction conditions on the photoluminescence properties of the microspheres was investigated. The quantum dots were immobilized on the surfaces of the microspheres through dehydration – condensation reactions between the carboxy groups of quantum dots and the amino groups of silane-treated microspheres. As the reaction time increased, the photoluminescence peak blue shifted, and the photoluminescence intensity and lifetime decreased. Therefore, a moderate period of the immobilization process was optimal for imparting effective photoluminescence properties. This study is expected to facilitate particle-level tracking of microsphere dynamics in biological tissues for the development of minimally invasive cancer radiotherapy of deep-seated tumors. |
| first_indexed | 2024-04-24T15:12:23Z |
| format | Article |
| id | doaj.art-105a71bce9c64e289b7755bb605283e3 |
| institution | Directory Open Access Journal |
| issn | 1468-6996 1878-5514 |
| language | English |
| last_indexed | 2024-04-24T15:12:23Z |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Science and Technology of Advanced Materials |
| spelling | doaj.art-105a71bce9c64e289b7755bb605283e32024-04-02T10:28:17ZengTaylor & Francis GroupScience and Technology of Advanced Materials1468-69961878-55142024-12-0125110.1080/14686996.2024.2331412Fabrication of quantum dot-immobilized Y2O3 microspheres with effective photoluminescence for cancer radioembolization therapyToshiki Miyazaki0Takumi Wakayama1Masaru Oda2Masakazu Kawashita3Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, Kitakyushu, JapanGraduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, Kitakyushu, JapanGraduate School of Engineering, Kyushu Institute of Technology, Kitakyushu, JapanInstitute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, JapanABSTRACTMicrospheres composed of Y-containing materials are effective agents for cancer radioembolization therapy using β-rays. The distribution and dynamics of these microspheres in tissues can be easily determined by providing the microspheres with an imaging function. In addition, the use of quantum dots will enable the detection of microspheres at the individual particle level with high sensitivity. In this study, core – shell quantum dots were bound to chemically modified yttria microspheres under various conditions, and the effect of reaction conditions on the photoluminescence properties of the microspheres was investigated. The quantum dots were immobilized on the surfaces of the microspheres through dehydration – condensation reactions between the carboxy groups of quantum dots and the amino groups of silane-treated microspheres. As the reaction time increased, the photoluminescence peak blue shifted, and the photoluminescence intensity and lifetime decreased. Therefore, a moderate period of the immobilization process was optimal for imparting effective photoluminescence properties. This study is expected to facilitate particle-level tracking of microsphere dynamics in biological tissues for the development of minimally invasive cancer radiotherapy of deep-seated tumors.https://www.tandfonline.com/doi/10.1080/14686996.2024.2331412Y2O3 microspherewater-in-oil emulsionquantum dotchemical immobilizationphotoluminescenceconcentration quenching |
| spellingShingle | Toshiki Miyazaki Takumi Wakayama Masaru Oda Masakazu Kawashita Fabrication of quantum dot-immobilized Y2O3 microspheres with effective photoluminescence for cancer radioembolization therapy Science and Technology of Advanced Materials Y2O3 microsphere water-in-oil emulsion quantum dot chemical immobilization photoluminescence concentration quenching |
| title | Fabrication of quantum dot-immobilized Y2O3 microspheres with effective photoluminescence for cancer radioembolization therapy |
| title_full | Fabrication of quantum dot-immobilized Y2O3 microspheres with effective photoluminescence for cancer radioembolization therapy |
| title_fullStr | Fabrication of quantum dot-immobilized Y2O3 microspheres with effective photoluminescence for cancer radioembolization therapy |
| title_full_unstemmed | Fabrication of quantum dot-immobilized Y2O3 microspheres with effective photoluminescence for cancer radioembolization therapy |
| title_short | Fabrication of quantum dot-immobilized Y2O3 microspheres with effective photoluminescence for cancer radioembolization therapy |
| title_sort | fabrication of quantum dot immobilized y2o3 microspheres with effective photoluminescence for cancer radioembolization therapy |
| topic | Y2O3 microsphere water-in-oil emulsion quantum dot chemical immobilization photoluminescence concentration quenching |
| url | https://www.tandfonline.com/doi/10.1080/14686996.2024.2331412 |
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