Phase I trial outcome of amnion cell therapy in patients with ischemic stroke (I-ACT)

Phase I trial outcome of amnion cell therapy in patients with ischemic stroke (I-ACT)

BackgroundWe proposed a Phase I dose escalation trial to assess the safety of allogeneic human amniotic epithelial cells (hAECs) in stroke patients with a view to informing the design for a Phase II trial.MethodsThe design is based on 3 + 3 dose escalation design with additional components for measu...

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Bibliographic Details
Main Authors: Thanh G. Phan, Rebecca Lim, Siow T. Chan, Hannah McDonald, Poh-Yi Gan, Shenpeng R. Zhang, Liz J. Barreto Arce, Jason Vuong, Tharani Thirugnanachandran, Benjamin Clissold, John Ly, Shaloo Singhal, Marie Veronic Hervet, Hyun Ah Kim, Grant R. Drummond, Euan M. Wallace, Henry Ma, Christopher G. Sobey
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Neuroscience
Subjects:
stem cell
clinical trial
ischemic stroke
phase I
allogeneic
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2023.1153231/full

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