Ovarian sex cord stromal tumours: analysis of the clinical and sonographic characteristics of different histopathologic subtypes
Abstract Background Ovarian sex cord stromal tumours (OSCSTs) are rare ovarian tumours and include different histopathologic subtypes. This study aimed to analyse the clinical and sonographic characteristics of different histopathologic OSCST subtypes. Methods A total of 63 patients with surgically...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-04-01
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| Series: | Journal of Ovarian Research |
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| Online Access: | https://doi.org/10.1186/s13048-021-00805-0 |
| _version_ | 1828081881009094656 |
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| author | Mei-jiao Jiang Qian Le Bo-wen Yang Fei Yuan Hui Chen |
| author_facet | Mei-jiao Jiang Qian Le Bo-wen Yang Fei Yuan Hui Chen |
| author_sort | Mei-jiao Jiang |
| collection | DOAJ |
| description | Abstract Background Ovarian sex cord stromal tumours (OSCSTs) are rare ovarian tumours and include different histopathologic subtypes. This study aimed to analyse the clinical and sonographic characteristics of different histopathologic OSCST subtypes. Methods A total of 63 patients with surgically proven OSCSTs were enrolled in this retrospective study to analyse their clinical and sonographic features. Ultrasound examinations and predictive models were performed before surgery. The clinical and sonographic findings were compared according to the type of OSCST based on the histopathological diagnosis. Results The mean age of 63 patients was 52.17 years (range: 17–78 years). Eighteen patients experienced irregular vaginal bleeding (28.57% 18/63), 7 patients exhibited abnormal body hair (11.11%). 2 patients (3.17%) showed an increased level of CA125, and 25 patients (39.68%, 25/63) showed an increased level of testosterone. Forty-two patients had ovarian thecoma-fibroma groups (OTFGs). Six patients had Sertoli-Leydig cell tumours (S-LCTs), 4 patients had Leydig cell tumours (LCTs), 8 patients had ovarian granulosa cell tumours (OGCTs), 2 patients had ovarian steroid cell tumours, not otherwise specified (OSCTs-NOS), and one patient had sclerosing stromal tumours (SSTs). The mean diameter of the tumour was 47.9 mm (range: 10–258 mm). Forty-seven masses were hypoechoic (74.60%). Twenty-eight masses had posterior echo attenuation, 22 masses exhibited abundant Doppler flow signals (34.92%), and one patient had ascites (1.59%). The diagnostic accuracy of the Simple Rules (SR) and the Assessment of Different NEoplasias in the adneXa (ADNEX) model in distinguishing benign and malignant OSCSTs was 44% (30/63) and 84% (53/63), respectively. The diagnostic accuracy of the SR for OTFGs, S-LCTs & LCTs & OSCTs-NOS, OGCTs, and SSTs was 47.6% (20/42), 16.67% (2/12), 100% (8/8), and 0% (0/1), respectively. The diagnostic accuracy of the ADNEX model for OTFGs, S-LCTs & LCTs & OSCTs-NOS, OGCTs, and SSTs was 93% (31/42), 58.33% (7/12), 75% (6/8), and 100% (1/1), respectively. Conclusions OSCSTs generally appear as a solid mass on ultrasound. Posterior echo attenuation indicates an OTFG. A solid mass with abundant Doppler flow signals indicates an S-LCT, LCT, OSCT-NOS or OGCT. Current predictive models are not very effective, but symptoms, sonographic features and serum hormones are helpful for diagnosis. |
| first_indexed | 2024-04-11T03:42:50Z |
| format | Article |
| id | doaj.art-105e11b1472442b6a2a7220bbc347518 |
| institution | Directory Open Access Journal |
| issn | 1757-2215 |
| language | English |
| last_indexed | 2024-04-11T03:42:50Z |
| publishDate | 2021-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Ovarian Research |
| spelling | doaj.art-105e11b1472442b6a2a7220bbc3475182023-01-02T03:19:24ZengBMCJournal of Ovarian Research1757-22152021-04-011411910.1186/s13048-021-00805-0Ovarian sex cord stromal tumours: analysis of the clinical and sonographic characteristics of different histopathologic subtypesMei-jiao Jiang0Qian Le1Bo-wen Yang2Fei Yuan3Hui Chen4Department of Obstetrics and Gynecology, Ruijin Hospital, Shanghai Jiaotong University School of MedicineDepartment of Obstetrics and Gynecology, Ruijin Hospital, Shanghai Jiaotong University School of MedicineDepartment of Obstetrics and Gynecology, Ruijin Hospital, Shanghai Jiaotong University School of MedicineDepartment of Pathology, Ruijin Hospital, Shanghai Jiaotong University School of MedicineDepartment of Obstetrics and Gynecology, Ruijin Hospital, Shanghai Jiaotong University School of MedicineAbstract Background Ovarian sex cord stromal tumours (OSCSTs) are rare ovarian tumours and include different histopathologic subtypes. This study aimed to analyse the clinical and sonographic characteristics of different histopathologic OSCST subtypes. Methods A total of 63 patients with surgically proven OSCSTs were enrolled in this retrospective study to analyse their clinical and sonographic features. Ultrasound examinations and predictive models were performed before surgery. The clinical and sonographic findings were compared according to the type of OSCST based on the histopathological diagnosis. Results The mean age of 63 patients was 52.17 years (range: 17–78 years). Eighteen patients experienced irregular vaginal bleeding (28.57% 18/63), 7 patients exhibited abnormal body hair (11.11%). 2 patients (3.17%) showed an increased level of CA125, and 25 patients (39.68%, 25/63) showed an increased level of testosterone. Forty-two patients had ovarian thecoma-fibroma groups (OTFGs). Six patients had Sertoli-Leydig cell tumours (S-LCTs), 4 patients had Leydig cell tumours (LCTs), 8 patients had ovarian granulosa cell tumours (OGCTs), 2 patients had ovarian steroid cell tumours, not otherwise specified (OSCTs-NOS), and one patient had sclerosing stromal tumours (SSTs). The mean diameter of the tumour was 47.9 mm (range: 10–258 mm). Forty-seven masses were hypoechoic (74.60%). Twenty-eight masses had posterior echo attenuation, 22 masses exhibited abundant Doppler flow signals (34.92%), and one patient had ascites (1.59%). The diagnostic accuracy of the Simple Rules (SR) and the Assessment of Different NEoplasias in the adneXa (ADNEX) model in distinguishing benign and malignant OSCSTs was 44% (30/63) and 84% (53/63), respectively. The diagnostic accuracy of the SR for OTFGs, S-LCTs & LCTs & OSCTs-NOS, OGCTs, and SSTs was 47.6% (20/42), 16.67% (2/12), 100% (8/8), and 0% (0/1), respectively. The diagnostic accuracy of the ADNEX model for OTFGs, S-LCTs & LCTs & OSCTs-NOS, OGCTs, and SSTs was 93% (31/42), 58.33% (7/12), 75% (6/8), and 100% (1/1), respectively. Conclusions OSCSTs generally appear as a solid mass on ultrasound. Posterior echo attenuation indicates an OTFG. A solid mass with abundant Doppler flow signals indicates an S-LCT, LCT, OSCT-NOS or OGCT. Current predictive models are not very effective, but symptoms, sonographic features and serum hormones are helpful for diagnosis.https://doi.org/10.1186/s13048-021-00805-0Ovarian thecoma-fibroma groupsSertoli-Leydig cell tumoursUltrasoundSimple rulesADNEX model |
| spellingShingle | Mei-jiao Jiang Qian Le Bo-wen Yang Fei Yuan Hui Chen Ovarian sex cord stromal tumours: analysis of the clinical and sonographic characteristics of different histopathologic subtypes Journal of Ovarian Research Ovarian thecoma-fibroma groups Sertoli-Leydig cell tumours Ultrasound Simple rules ADNEX model |
| title | Ovarian sex cord stromal tumours: analysis of the clinical and sonographic characteristics of different histopathologic subtypes |
| title_full | Ovarian sex cord stromal tumours: analysis of the clinical and sonographic characteristics of different histopathologic subtypes |
| title_fullStr | Ovarian sex cord stromal tumours: analysis of the clinical and sonographic characteristics of different histopathologic subtypes |
| title_full_unstemmed | Ovarian sex cord stromal tumours: analysis of the clinical and sonographic characteristics of different histopathologic subtypes |
| title_short | Ovarian sex cord stromal tumours: analysis of the clinical and sonographic characteristics of different histopathologic subtypes |
| title_sort | ovarian sex cord stromal tumours analysis of the clinical and sonographic characteristics of different histopathologic subtypes |
| topic | Ovarian thecoma-fibroma groups Sertoli-Leydig cell tumours Ultrasound Simple rules ADNEX model |
| url | https://doi.org/10.1186/s13048-021-00805-0 |
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