Desquamative interstitial pneumonia: A case report
Introduction. Desquamative interstitial pneumonia is one of the rarest idiopathic interstitial pneumonias and the rarest form of smoking-related interstitial lung diseases. It was first described by Liebow in 1965. Histologically, it is characterized by the presence of eosinophilic macro...
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| Format: | Article |
| Language: | English |
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Serbian Medical Society
2014-01-01
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| Series: | Srpski Arhiv za Celokupno Lekarstvo |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0370-8179/2014/0370-81791410602L.pdf |
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| author | Lovrenski Aleksandra Eri Živka Tegeltija Dragana Kašiković-Lečić Svetlana Panjković Milana |
| author_facet | Lovrenski Aleksandra Eri Živka Tegeltija Dragana Kašiković-Lečić Svetlana Panjković Milana |
| author_sort | Lovrenski Aleksandra |
| collection | DOAJ |
| description | Introduction. Desquamative interstitial pneumonia is one of the rarest
idiopathic interstitial pneumonias and the rarest form of smoking-related
interstitial lung diseases. It was first described by Liebow in 1965.
Histologically, it is characterized by the presence of eosinophilic
macrophages uniformly filling airspaces which often contain a finely granular
light-brown pigment that does not stain for hemosiderin. The alveolar walls
are usually mildly thickened by fibrous tissue and infiltrated by a moderate
number of lymphocytes. Case Outline. Our patient was a 56-year-old male,
heavy smoker, with bilateral lung infiltrations of unknown etiology and
several months of discomfort in the form of dry cough and shortness of
breath. Lung function tests showed a moderate restrictive ventilation
disorder and a severe reduction of diffusing capacity. Since bronchoscopic
specimens did not reveal lung lesion etiology, an open lung biopsy of the
lower left pulmonary lobe was performed, and based on the obtained surgical
material the pathohistologically diagnosis of desquamative interstitial
pneumonia was established. The patient was started on corticosteroid and
immunosuppressive therapy, and he ceased smoking. At the last control
examination, two years after the onset of symptoms, the patient was feeling
well, and high-resolution computed tomography (HRCT) scan of the thorax
showed regression of pathological changes. Conclusion. Although, as in our
case, the majority of DIP patients improve on treatment, some patients still
develop progressive irreversible fibrosis despite therapy. |
| first_indexed | 2024-12-20T01:40:08Z |
| format | Article |
| id | doaj.art-105f4a63b2d947c28142aa0a354f1b11 |
| institution | Directory Open Access Journal |
| issn | 0370-8179 |
| language | English |
| last_indexed | 2024-12-20T01:40:08Z |
| publishDate | 2014-01-01 |
| publisher | Serbian Medical Society |
| record_format | Article |
| series | Srpski Arhiv za Celokupno Lekarstvo |
| spelling | doaj.art-105f4a63b2d947c28142aa0a354f1b112022-12-21T19:57:54ZengSerbian Medical SocietySrpski Arhiv za Celokupno Lekarstvo0370-81792014-01-011429-1060260610.2298/SARH1410602L0370-81791410602LDesquamative interstitial pneumonia: A case reportLovrenski Aleksandra0Eri Živka1Tegeltija Dragana2Kašiković-Lečić Svetlana3Panjković Milana4Institute for Pulmonary Diseases of Vojvodina, Center for Pathology, Sremska KamenicaInstitute for Pulmonary Diseases of Vojvodina, Center for Pathology, Sremska KamenicaInstitute for Pulmonary Diseases of Vojvodina, Center for Pathology, Sremska KamenicaInstitute for Pulmonary Diseases of Vojvodina, Clinic for Tuberculosis and Granulomatous Diseases, Sremska KamenicaInstitute for Pulmonary Diseases of Vojvodina, Center for Pathology, Sremska KamenicaIntroduction. Desquamative interstitial pneumonia is one of the rarest idiopathic interstitial pneumonias and the rarest form of smoking-related interstitial lung diseases. It was first described by Liebow in 1965. Histologically, it is characterized by the presence of eosinophilic macrophages uniformly filling airspaces which often contain a finely granular light-brown pigment that does not stain for hemosiderin. The alveolar walls are usually mildly thickened by fibrous tissue and infiltrated by a moderate number of lymphocytes. Case Outline. Our patient was a 56-year-old male, heavy smoker, with bilateral lung infiltrations of unknown etiology and several months of discomfort in the form of dry cough and shortness of breath. Lung function tests showed a moderate restrictive ventilation disorder and a severe reduction of diffusing capacity. Since bronchoscopic specimens did not reveal lung lesion etiology, an open lung biopsy of the lower left pulmonary lobe was performed, and based on the obtained surgical material the pathohistologically diagnosis of desquamative interstitial pneumonia was established. The patient was started on corticosteroid and immunosuppressive therapy, and he ceased smoking. At the last control examination, two years after the onset of symptoms, the patient was feeling well, and high-resolution computed tomography (HRCT) scan of the thorax showed regression of pathological changes. Conclusion. Although, as in our case, the majority of DIP patients improve on treatment, some patients still develop progressive irreversible fibrosis despite therapy.http://www.doiserbia.nb.rs/img/doi/0370-8179/2014/0370-81791410602L.pdfdesquamative interstitial pneumoniainterstitial lung diseasesmokingsmokersmacrophagessmoking-related interstitial lung disease |
| spellingShingle | Lovrenski Aleksandra Eri Živka Tegeltija Dragana Kašiković-Lečić Svetlana Panjković Milana Desquamative interstitial pneumonia: A case report Srpski Arhiv za Celokupno Lekarstvo desquamative interstitial pneumonia interstitial lung disease smoking smokers macrophages smoking-related interstitial lung disease |
| title | Desquamative interstitial pneumonia: A case report |
| title_full | Desquamative interstitial pneumonia: A case report |
| title_fullStr | Desquamative interstitial pneumonia: A case report |
| title_full_unstemmed | Desquamative interstitial pneumonia: A case report |
| title_short | Desquamative interstitial pneumonia: A case report |
| title_sort | desquamative interstitial pneumonia a case report |
| topic | desquamative interstitial pneumonia interstitial lung disease smoking smokers macrophages smoking-related interstitial lung disease |
| url | http://www.doiserbia.nb.rs/img/doi/0370-8179/2014/0370-81791410602L.pdf |
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