Surveillance of Sensitivity to Penicillin in streptococcus Agalactiae recovered from pregnant women between 35-37 weeks of gestation.
<p><em>Streptococcus agalactiae</em> (GBS) cause severe infections in newborns under three months. Meningitis, pneumonia and sepsis are the main infectious diseases in these children. These infections are among the most serious that an individual can suffer in his first twelve hour...
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| Format: | Article |
| Language: | English |
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Universidad Nacional de Córdoba
2017-12-01
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| Series: | Revista de la Facultad de Ciencias Médicas de Córdoba |
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| Online Access: | https://revistas.unc.edu.ar/index.php/med/article/view/16395 |
| _version_ | 1818595784868757504 |
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| author | Lucía Müller Velázquez Fernando Bobadilla Marina Novosak Iliana Cortese Margarita Laczeski |
| author_facet | Lucía Müller Velázquez Fernando Bobadilla Marina Novosak Iliana Cortese Margarita Laczeski |
| author_sort | Lucía Müller Velázquez |
| collection | DOAJ |
| description | <p><em>Streptococcus agalactiae</em> (GBS) cause severe infections in newborns under three months. Meningitis, pneumonia and sepsis are the main infectious diseases in these children. These infections are among the most serious that an individual can suffer in his first twelve hours of life. The child acquires the infection by vertical transmission of the colonized mother. To prevent neonatal disease, penicillin is recommended as the drug of choice for intrapartum prophylaxis (PIP) in pregnant women colonized. However, strains with decreased susceptibility to penicillin have been detected so it is important to monitor the susceptibility to penicillin to ensure its usefulness during prophylaxis. The aim of this study was to determine the sensitivity to penicillin in GBS strains recovered from pregnant women with 35-37 weeks of gestation. Ninety-six isolates were studied and sensitivity was determined by the epsilometric method Etest® (LIOFILCHEM, Italy), following the recommendations of the Clinical Laboratory Standards Institute (CLSI). Minimum Inhibitory Concentration (MIC) was obtained for each bacterial isolation. 100% (96) of the strains studied were sensitive to penicillin with MIC values between 0.012 and 0.094 ?g mL-1. These results indicate that penicillin remains the antimicrobial of choice during intrapartum prophylaxis, for the prevention of neonatal disease caused by GBS in our region. The importance of epidemiological surveillance of sensitivity to penicillin and other antimicrobials is highlighted in order to alert new resistance mechanisms and to adapt treatment strategies.</p> |
| first_indexed | 2024-12-16T11:21:31Z |
| format | Article |
| id | doaj.art-105fba049ae54943ae9f523eebc5f4d8 |
| institution | Directory Open Access Journal |
| issn | 0014-6722 1853-0605 |
| language | English |
| last_indexed | 2024-12-16T11:21:31Z |
| publishDate | 2017-12-01 |
| publisher | Universidad Nacional de Córdoba |
| record_format | Article |
| series | Revista de la Facultad de Ciencias Médicas de Córdoba |
| spelling | doaj.art-105fba049ae54943ae9f523eebc5f4d82022-12-21T22:33:28ZengUniversidad Nacional de CórdobaRevista de la Facultad de Ciencias Médicas de Córdoba0014-67221853-06052017-12-0174432032410.31053/1853.0605.v74.n4.1639516628Surveillance of Sensitivity to Penicillin in streptococcus Agalactiae recovered from pregnant women between 35-37 weeks of gestation.Lucía Müller Velázquez0Fernando Bobadilla1Marina Novosak2Iliana Cortese3Margarita Laczeski4- Cátedra de Microbiología General, Departamento de Microbiología, Facultad de Ciencias y Tecnología, Universidad Nacional de Itapúa. Encarnación, Paraguay.- Cátedra de Bacteriología, Departamento de Microbiología, Facultad de Ciencias Exactas, Químicas y Naturales. Universidad Nacional de Misiones. Posadas, Argentina. - Laboratorio de Biotecnología Molecular, Instituto de Biotecnología Misiones “Dra. María Ebe Reca”, Facultad de Ciencias Exactas, Químicas y Naturales. Universidad Nacional de Misiones. Posadas, Argentina.- Cátedra de Bacteriología, Departamento de Microbiología, Facultad de Ciencias Exactas, Químicas y Naturales. Universidad Nacional de Misiones. Posadas, Argentina. - Laboratorio de Biotecnología Molecular, Instituto de Biotecnología Misiones “Dra. María Ebe Reca”, Facultad de Ciencias Exactas, Químicas y Naturales. Universidad Nacional de Misiones. Posadas, Argentina.-Laboratorio de Biotecnología Molecular, Instituto de Biotecnología Misiones “Dra. María Ebe Reca”, Facultad de Ciencias Exactas, Químicas y Naturales. Universidad Nacional de Misiones. Posadas, Argentina.-Cátedra de Bacteriología, Departamento de Microbiología, Facultad de Ciencias Exactas, Químicas y Naturales. Universidad Nacional de Misiones. Posadas, Argentina. -Laboratorio de Biotecnología Molecular, Instituto de Biotecnología Misiones “Dra. María Ebe Reca”, Facultad de Ciencias Exactas, Químicas y Naturales. Universidad Nacional de Misiones. Posadas, Argentina.<p><em>Streptococcus agalactiae</em> (GBS) cause severe infections in newborns under three months. Meningitis, pneumonia and sepsis are the main infectious diseases in these children. These infections are among the most serious that an individual can suffer in his first twelve hours of life. The child acquires the infection by vertical transmission of the colonized mother. To prevent neonatal disease, penicillin is recommended as the drug of choice for intrapartum prophylaxis (PIP) in pregnant women colonized. However, strains with decreased susceptibility to penicillin have been detected so it is important to monitor the susceptibility to penicillin to ensure its usefulness during prophylaxis. The aim of this study was to determine the sensitivity to penicillin in GBS strains recovered from pregnant women with 35-37 weeks of gestation. Ninety-six isolates were studied and sensitivity was determined by the epsilometric method Etest® (LIOFILCHEM, Italy), following the recommendations of the Clinical Laboratory Standards Institute (CLSI). Minimum Inhibitory Concentration (MIC) was obtained for each bacterial isolation. 100% (96) of the strains studied were sensitive to penicillin with MIC values between 0.012 and 0.094 ?g mL-1. These results indicate that penicillin remains the antimicrobial of choice during intrapartum prophylaxis, for the prevention of neonatal disease caused by GBS in our region. The importance of epidemiological surveillance of sensitivity to penicillin and other antimicrobials is highlighted in order to alert new resistance mechanisms and to adapt treatment strategies.</p>https://revistas.unc.edu.ar/index.php/med/article/view/16395Streptococcus agalactiaeSGBantimicrobianopenicilinaprofilaxis intraparto |
| spellingShingle | Lucía Müller Velázquez Fernando Bobadilla Marina Novosak Iliana Cortese Margarita Laczeski Surveillance of Sensitivity to Penicillin in streptococcus Agalactiae recovered from pregnant women between 35-37 weeks of gestation. Revista de la Facultad de Ciencias Médicas de Córdoba Streptococcus agalactiae SGB antimicrobiano penicilina profilaxis intraparto |
| title | Surveillance of Sensitivity to Penicillin in streptococcus Agalactiae recovered from pregnant women between 35-37 weeks of gestation. |
| title_full | Surveillance of Sensitivity to Penicillin in streptococcus Agalactiae recovered from pregnant women between 35-37 weeks of gestation. |
| title_fullStr | Surveillance of Sensitivity to Penicillin in streptococcus Agalactiae recovered from pregnant women between 35-37 weeks of gestation. |
| title_full_unstemmed | Surveillance of Sensitivity to Penicillin in streptococcus Agalactiae recovered from pregnant women between 35-37 weeks of gestation. |
| title_short | Surveillance of Sensitivity to Penicillin in streptococcus Agalactiae recovered from pregnant women between 35-37 weeks of gestation. |
| title_sort | surveillance of sensitivity to penicillin in streptococcus agalactiae recovered from pregnant women between 35 37 weeks of gestation |
| topic | Streptococcus agalactiae SGB antimicrobiano penicilina profilaxis intraparto |
| url | https://revistas.unc.edu.ar/index.php/med/article/view/16395 |
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