Protozoa-Derived Extracellular Vesicles on Intercellular Communication with Special Emphasis on <i>Giardia lamblia</i>
Parasitic diseases are an important worldwide problem threatening human health and affect millions of people. Acute diarrhea, intestinal bleeding, malabsorption of nutrients and nutritional deficiency are some of the issues related to intestinal parasitic infections. Parasites are experts in subvert...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Microorganisms |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-2607/10/12/2422 |
| _version_ | 1797456125049700352 |
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| author | Bárbara Ferreira Ágata Lourenço Maria do Céu Sousa |
| author_facet | Bárbara Ferreira Ágata Lourenço Maria do Céu Sousa |
| author_sort | Bárbara Ferreira |
| collection | DOAJ |
| description | Parasitic diseases are an important worldwide problem threatening human health and affect millions of people. Acute diarrhea, intestinal bleeding, malabsorption of nutrients and nutritional deficiency are some of the issues related to intestinal parasitic infections. Parasites are experts in subvert the host immune system through different kinds of mechanisms. There are evidences that extracellular vesicles (EVs) have an important role in dissemination of the disease and in modulating the host immune system. Released by almost all types of cells, these nanovesicles are a natural secretory product containing multiple components of interest. The EVs are classified as apoptotic bodies, microvesicles, exosomes, ectosomes, and microparticles, according to their physical characteristics, biochemical composition and cell of origin. Interestingly, EVs play an important role in intercellular communication between parasites as well as with the host cells. Concerning <i>Giardia lamblia</i>, it is known that this parasite release EVs during it life cycle that modulate the parasite growth and adherence as well the immune system of the host. Here we review the recently updates on protozoa EVs, with particular emphasis on the role of EVs released by the flagellate protozoa <i>G. lamblia</i> in cellular communication and its potential for future applications as vaccine, therapeutic agent, drug delivery system and as diagnostic or prognostic biomarker. |
| first_indexed | 2024-03-09T16:03:52Z |
| format | Article |
| id | doaj.art-106259860e35428bbd6d0c8c77e84a42 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-09T16:03:52Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-106259860e35428bbd6d0c8c77e84a422023-11-24T16:48:50ZengMDPI AGMicroorganisms2076-26072022-12-011012242210.3390/microorganisms10122422Protozoa-Derived Extracellular Vesicles on Intercellular Communication with Special Emphasis on <i>Giardia lamblia</i>Bárbara Ferreira0Ágata Lourenço1Maria do Céu Sousa2CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 Coimbra, PortugalCNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 Coimbra, PortugalCNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 Coimbra, PortugalParasitic diseases are an important worldwide problem threatening human health and affect millions of people. Acute diarrhea, intestinal bleeding, malabsorption of nutrients and nutritional deficiency are some of the issues related to intestinal parasitic infections. Parasites are experts in subvert the host immune system through different kinds of mechanisms. There are evidences that extracellular vesicles (EVs) have an important role in dissemination of the disease and in modulating the host immune system. Released by almost all types of cells, these nanovesicles are a natural secretory product containing multiple components of interest. The EVs are classified as apoptotic bodies, microvesicles, exosomes, ectosomes, and microparticles, according to their physical characteristics, biochemical composition and cell of origin. Interestingly, EVs play an important role in intercellular communication between parasites as well as with the host cells. Concerning <i>Giardia lamblia</i>, it is known that this parasite release EVs during it life cycle that modulate the parasite growth and adherence as well the immune system of the host. Here we review the recently updates on protozoa EVs, with particular emphasis on the role of EVs released by the flagellate protozoa <i>G. lamblia</i> in cellular communication and its potential for future applications as vaccine, therapeutic agent, drug delivery system and as diagnostic or prognostic biomarker.https://www.mdpi.com/2076-2607/10/12/2422extracellular vesicles (EVs)protozoan<i>Trichomonas</i><i>Entamoeba</i><i>Leishmania</i><i>Trypanosoma</i> |
| spellingShingle | Bárbara Ferreira Ágata Lourenço Maria do Céu Sousa Protozoa-Derived Extracellular Vesicles on Intercellular Communication with Special Emphasis on <i>Giardia lamblia</i> Microorganisms extracellular vesicles (EVs) protozoan <i>Trichomonas</i> <i>Entamoeba</i> <i>Leishmania</i> <i>Trypanosoma</i> |
| title | Protozoa-Derived Extracellular Vesicles on Intercellular Communication with Special Emphasis on <i>Giardia lamblia</i> |
| title_full | Protozoa-Derived Extracellular Vesicles on Intercellular Communication with Special Emphasis on <i>Giardia lamblia</i> |
| title_fullStr | Protozoa-Derived Extracellular Vesicles on Intercellular Communication with Special Emphasis on <i>Giardia lamblia</i> |
| title_full_unstemmed | Protozoa-Derived Extracellular Vesicles on Intercellular Communication with Special Emphasis on <i>Giardia lamblia</i> |
| title_short | Protozoa-Derived Extracellular Vesicles on Intercellular Communication with Special Emphasis on <i>Giardia lamblia</i> |
| title_sort | protozoa derived extracellular vesicles on intercellular communication with special emphasis on i giardia lamblia i |
| topic | extracellular vesicles (EVs) protozoan <i>Trichomonas</i> <i>Entamoeba</i> <i>Leishmania</i> <i>Trypanosoma</i> |
| url | https://www.mdpi.com/2076-2607/10/12/2422 |
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