Performance of the recommended ESC/EASD cardiovascular risk stratification model in comparison to SCORE and NT-proBNP as a single biomarker for risk prediction in type 2 diabetes mellitus
Abstract Background Recently, the European Society of Cardiology (ESC) and European Association for the Society of Diabetes (EASD) introduced a new cardiovascular disease (CVD) risk stratification model to aid further treatment decisions in individuals with diabetes. Our study aimed to investigate t...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-02-01
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| Series: | Cardiovascular Diabetology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12933-021-01221-w |
| _version_ | 1819275429298569216 |
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| author | Suriya Prausmüller Michael Resl Henrike Arfsten Georg Spinka Raphael Wurm Stephanie Neuhold Philipp E. Bartko Georg Goliasch Guido Strunk Noemi Pavo Martin Clodi Martin Hülsmann |
| author_facet | Suriya Prausmüller Michael Resl Henrike Arfsten Georg Spinka Raphael Wurm Stephanie Neuhold Philipp E. Bartko Georg Goliasch Guido Strunk Noemi Pavo Martin Clodi Martin Hülsmann |
| author_sort | Suriya Prausmüller |
| collection | DOAJ |
| description | Abstract Background Recently, the European Society of Cardiology (ESC) and European Association for the Society of Diabetes (EASD) introduced a new cardiovascular disease (CVD) risk stratification model to aid further treatment decisions in individuals with diabetes. Our study aimed to investigate the prognostic performance of the ESC/EASD risk model in comparison to the Systematic COronary Risk Evaluation (SCORE) risk model and N-terminal pro-B-type natriuretic peptide (NT-proBNP) in an unselected cohort of type 2 diabetes mellitus (T2DM). Methods and results A total of 1690 T2DM patients with a 10-year follow up for fatal CVD and all-cause death and a 5-year follow up for CVD and all-cause hospitalizations were analyzed. According to ESC/EASD risk criteria 25 (1.5%) patients were classified as moderate, 252 (14.9%) high, 1125 (66.6%) very high risk and 288 (17.0%) were not classifiable. Both NT-proBNP and SCORE risk model were associated with 10-year CVD and all-cause death and 5-year CVD and all-cause hospitalizations while the ESC/EASD model was only associated with 10-year all-cause death and 5-year all-cause hospitalizations. NT-proBNP and SCORE showed significantly higher C-indices than the ESC/EASD risk model for CVD death [0.80 vs. 0.53, p < 0.001; 0.64 vs. 0.53, p = 0.001] and all-cause death [0.73, 0.66 vs. 0.52, p < 0.001 for both]. The performance of SCORE improved in a subgroup without CVD aged 40–64 years compared to the unselected cohort, while NT-proBNP performance was robust across all groups. Conclusion The new introduced ESC/EASD risk stratification model performed limited compared to SCORE and single NT-proBNP assessment for predicting 10-year CVD and all-cause fatal events in individuals with T2DM. |
| first_indexed | 2024-12-23T23:24:11Z |
| format | Article |
| id | doaj.art-1062bee2694a48319dcab8ce8b167204 |
| institution | Directory Open Access Journal |
| issn | 1475-2840 |
| language | English |
| last_indexed | 2024-12-23T23:24:11Z |
| publishDate | 2021-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Diabetology |
| spelling | doaj.art-1062bee2694a48319dcab8ce8b1672042022-12-21T17:26:16ZengBMCCardiovascular Diabetology1475-28402021-02-0120111210.1186/s12933-021-01221-wPerformance of the recommended ESC/EASD cardiovascular risk stratification model in comparison to SCORE and NT-proBNP as a single biomarker for risk prediction in type 2 diabetes mellitusSuriya Prausmüller0Michael Resl1Henrike Arfsten2Georg Spinka3Raphael Wurm4Stephanie Neuhold5Philipp E. Bartko6Georg Goliasch7Guido Strunk8Noemi Pavo9Martin Clodi10Martin Hülsmann11Department of Internal Medicine II, Medical University of ViennaDepartment of Internal Medicine, Saint John of God Hospital LinzDepartment of Internal Medicine II, Medical University of ViennaDepartment of Internal Medicine II, Medical University of ViennaDepartment of Internal Medicine II, Medical University of ViennaDepartment of Medicine IV, Clinic FavoritenDepartment of Internal Medicine II, Medical University of ViennaDepartment of Internal Medicine II, Medical University of ViennaComplexity ResearchDepartment of Internal Medicine II, Medical University of ViennaDepartment of Internal Medicine, Saint John of God Hospital LinzDepartment of Internal Medicine II, Medical University of ViennaAbstract Background Recently, the European Society of Cardiology (ESC) and European Association for the Society of Diabetes (EASD) introduced a new cardiovascular disease (CVD) risk stratification model to aid further treatment decisions in individuals with diabetes. Our study aimed to investigate the prognostic performance of the ESC/EASD risk model in comparison to the Systematic COronary Risk Evaluation (SCORE) risk model and N-terminal pro-B-type natriuretic peptide (NT-proBNP) in an unselected cohort of type 2 diabetes mellitus (T2DM). Methods and results A total of 1690 T2DM patients with a 10-year follow up for fatal CVD and all-cause death and a 5-year follow up for CVD and all-cause hospitalizations were analyzed. According to ESC/EASD risk criteria 25 (1.5%) patients were classified as moderate, 252 (14.9%) high, 1125 (66.6%) very high risk and 288 (17.0%) were not classifiable. Both NT-proBNP and SCORE risk model were associated with 10-year CVD and all-cause death and 5-year CVD and all-cause hospitalizations while the ESC/EASD model was only associated with 10-year all-cause death and 5-year all-cause hospitalizations. NT-proBNP and SCORE showed significantly higher C-indices than the ESC/EASD risk model for CVD death [0.80 vs. 0.53, p < 0.001; 0.64 vs. 0.53, p = 0.001] and all-cause death [0.73, 0.66 vs. 0.52, p < 0.001 for both]. The performance of SCORE improved in a subgroup without CVD aged 40–64 years compared to the unselected cohort, while NT-proBNP performance was robust across all groups. Conclusion The new introduced ESC/EASD risk stratification model performed limited compared to SCORE and single NT-proBNP assessment for predicting 10-year CVD and all-cause fatal events in individuals with T2DM.https://doi.org/10.1186/s12933-021-01221-wDiabetes mellitusCardiovascular riskPrevention |
| spellingShingle | Suriya Prausmüller Michael Resl Henrike Arfsten Georg Spinka Raphael Wurm Stephanie Neuhold Philipp E. Bartko Georg Goliasch Guido Strunk Noemi Pavo Martin Clodi Martin Hülsmann Performance of the recommended ESC/EASD cardiovascular risk stratification model in comparison to SCORE and NT-proBNP as a single biomarker for risk prediction in type 2 diabetes mellitus Cardiovascular Diabetology Diabetes mellitus Cardiovascular risk Prevention |
| title | Performance of the recommended ESC/EASD cardiovascular risk stratification model in comparison to SCORE and NT-proBNP as a single biomarker for risk prediction in type 2 diabetes mellitus |
| title_full | Performance of the recommended ESC/EASD cardiovascular risk stratification model in comparison to SCORE and NT-proBNP as a single biomarker for risk prediction in type 2 diabetes mellitus |
| title_fullStr | Performance of the recommended ESC/EASD cardiovascular risk stratification model in comparison to SCORE and NT-proBNP as a single biomarker for risk prediction in type 2 diabetes mellitus |
| title_full_unstemmed | Performance of the recommended ESC/EASD cardiovascular risk stratification model in comparison to SCORE and NT-proBNP as a single biomarker for risk prediction in type 2 diabetes mellitus |
| title_short | Performance of the recommended ESC/EASD cardiovascular risk stratification model in comparison to SCORE and NT-proBNP as a single biomarker for risk prediction in type 2 diabetes mellitus |
| title_sort | performance of the recommended esc easd cardiovascular risk stratification model in comparison to score and nt probnp as a single biomarker for risk prediction in type 2 diabetes mellitus |
| topic | Diabetes mellitus Cardiovascular risk Prevention |
| url | https://doi.org/10.1186/s12933-021-01221-w |
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