Ube2D3 and Ube2N are essential for RIG-I-mediated MAVS aggregation in antiviral innate immunity
The RIG-I-MAVS signalling pathway plays an important role in sensing virus infection. Here the authors identify the ubiquitin-conjugating enzymes Ube2D3 and Ube2N as essential for RIG-I activation and define their roles in mediating MAVS aggregation.
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms15138 |
| _version_ | 1818996253717954560 |
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| author | Yuheng Shi Bofeng Yuan Wenting Zhu Rui Zhang Lin Li Xiaojing Hao She Chen Fajian Hou |
| author_facet | Yuheng Shi Bofeng Yuan Wenting Zhu Rui Zhang Lin Li Xiaojing Hao She Chen Fajian Hou |
| author_sort | Yuheng Shi |
| collection | DOAJ |
| description | The RIG-I-MAVS signalling pathway plays an important role in sensing virus infection. Here the authors identify the ubiquitin-conjugating enzymes Ube2D3 and Ube2N as essential for RIG-I activation and define their roles in mediating MAVS aggregation. |
| first_indexed | 2024-12-20T21:26:48Z |
| format | Article |
| id | doaj.art-1063152fa3d74e488b696ce78d06b044 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T21:26:48Z |
| publishDate | 2017-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-1063152fa3d74e488b696ce78d06b0442022-12-21T19:26:08ZengNature PortfolioNature Communications2041-17232017-05-018111410.1038/ncomms15138Ube2D3 and Ube2N are essential for RIG-I-mediated MAVS aggregation in antiviral innate immunityYuheng Shi0Bofeng Yuan1Wenting Zhu2Rui Zhang3Lin Li4Xiaojing Hao5She Chen6Fajian Hou7State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Innovation Center for Cell Signaling Network, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of SciencesState Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Innovation Center for Cell Signaling Network, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of SciencesState Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Innovation Center for Cell Signaling Network, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of SciencesState Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Innovation Center for Cell Signaling Network, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of SciencesNational Institute of Biological SciencesState Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Innovation Center for Cell Signaling Network, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of SciencesNational Institute of Biological SciencesState Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Innovation Center for Cell Signaling Network, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of SciencesThe RIG-I-MAVS signalling pathway plays an important role in sensing virus infection. Here the authors identify the ubiquitin-conjugating enzymes Ube2D3 and Ube2N as essential for RIG-I activation and define their roles in mediating MAVS aggregation.https://doi.org/10.1038/ncomms15138 |
| spellingShingle | Yuheng Shi Bofeng Yuan Wenting Zhu Rui Zhang Lin Li Xiaojing Hao She Chen Fajian Hou Ube2D3 and Ube2N are essential for RIG-I-mediated MAVS aggregation in antiviral innate immunity Nature Communications |
| title | Ube2D3 and Ube2N are essential for RIG-I-mediated MAVS aggregation in antiviral innate immunity |
| title_full | Ube2D3 and Ube2N are essential for RIG-I-mediated MAVS aggregation in antiviral innate immunity |
| title_fullStr | Ube2D3 and Ube2N are essential for RIG-I-mediated MAVS aggregation in antiviral innate immunity |
| title_full_unstemmed | Ube2D3 and Ube2N are essential for RIG-I-mediated MAVS aggregation in antiviral innate immunity |
| title_short | Ube2D3 and Ube2N are essential for RIG-I-mediated MAVS aggregation in antiviral innate immunity |
| title_sort | ube2d3 and ube2n are essential for rig i mediated mavs aggregation in antiviral innate immunity |
| url | https://doi.org/10.1038/ncomms15138 |
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