Construction and Tribological Properties of Biomimetic Cartilage-Lubricating Hydrogels
Articular cartilage provides ultralow friction to maintain the physiological function of the knee joint, which arises from the hierarchical complex composed of hyaluronic acid, phospholipids, and lubricin, covering the cartilage surface as boundary lubrication layers. Cartilage-lubricating polymers...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Gels |
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| Online Access: | https://www.mdpi.com/2310-2861/8/7/415 |
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| author | Qiuyi Chen Sa Liu Zhongrun Yuan Hai Yang Renjian Xie Li Ren |
| author_facet | Qiuyi Chen Sa Liu Zhongrun Yuan Hai Yang Renjian Xie Li Ren |
| author_sort | Qiuyi Chen |
| collection | DOAJ |
| description | Articular cartilage provides ultralow friction to maintain the physiological function of the knee joint, which arises from the hierarchical complex composed of hyaluronic acid, phospholipids, and lubricin, covering the cartilage surface as boundary lubrication layers. Cartilage-lubricating polymers (HA/PA and HA/PM) mimicking this complex have been demonstrated to restore the lubrication of cartilage via hydration lubrication, thus contributing to the treatment of early osteoarthritis (OA) in vivo. Here, biomimetic cartilage-lubricating hydrogels (HPX/PVA) were constructed by blending HA/PA and HA/PM (HPX) with polyvinyl alcohol (PVA) to improve the boundary lubrication and wear properties, so that the obtained hydrogels may offer a solution to the main drawbacks of PVA hydrogels used as cartilage implants. The HPX/PVA hydrogels exhibited good physicochemical and mechanical properties through hydrogen-bonding interactions, and showed lower friction and wear under the boundary lubrication and fluid film lubrication mechanisms, which remained when the hydrogels were rehydrated. Our strategy may provide new insights into exploring cartilage-inspired lubricating hydrogels. |
| first_indexed | 2024-03-09T03:23:12Z |
| format | Article |
| id | doaj.art-1063c48f78d64a89b641f0bc47412287 |
| institution | Directory Open Access Journal |
| issn | 2310-2861 |
| language | English |
| last_indexed | 2024-03-09T03:23:12Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj.art-1063c48f78d64a89b641f0bc474122872023-12-03T15:05:08ZengMDPI AGGels2310-28612022-07-018741510.3390/gels8070415Construction and Tribological Properties of Biomimetic Cartilage-Lubricating HydrogelsQiuyi Chen0Sa Liu1Zhongrun Yuan2Hai Yang3Renjian Xie4Li Ren5School of Biomedical Science and Engineering, South China University of Technology, Guangzhou 510006, ChinaNational Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510006, ChinaNational Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510006, ChinaNational Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510006, ChinaSchool of Medical Information Engineering, Gannan Medical University, Ganzhou 341000, ChinaNational Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510006, ChinaArticular cartilage provides ultralow friction to maintain the physiological function of the knee joint, which arises from the hierarchical complex composed of hyaluronic acid, phospholipids, and lubricin, covering the cartilage surface as boundary lubrication layers. Cartilage-lubricating polymers (HA/PA and HA/PM) mimicking this complex have been demonstrated to restore the lubrication of cartilage via hydration lubrication, thus contributing to the treatment of early osteoarthritis (OA) in vivo. Here, biomimetic cartilage-lubricating hydrogels (HPX/PVA) were constructed by blending HA/PA and HA/PM (HPX) with polyvinyl alcohol (PVA) to improve the boundary lubrication and wear properties, so that the obtained hydrogels may offer a solution to the main drawbacks of PVA hydrogels used as cartilage implants. The HPX/PVA hydrogels exhibited good physicochemical and mechanical properties through hydrogen-bonding interactions, and showed lower friction and wear under the boundary lubrication and fluid film lubrication mechanisms, which remained when the hydrogels were rehydrated. Our strategy may provide new insights into exploring cartilage-inspired lubricating hydrogels.https://www.mdpi.com/2310-2861/8/7/415articular cartilageosteoarthritiscartilage replacementpolyvinyl alcoholhydrogelslubrication |
| spellingShingle | Qiuyi Chen Sa Liu Zhongrun Yuan Hai Yang Renjian Xie Li Ren Construction and Tribological Properties of Biomimetic Cartilage-Lubricating Hydrogels Gels articular cartilage osteoarthritis cartilage replacement polyvinyl alcohol hydrogels lubrication |
| title | Construction and Tribological Properties of Biomimetic Cartilage-Lubricating Hydrogels |
| title_full | Construction and Tribological Properties of Biomimetic Cartilage-Lubricating Hydrogels |
| title_fullStr | Construction and Tribological Properties of Biomimetic Cartilage-Lubricating Hydrogels |
| title_full_unstemmed | Construction and Tribological Properties of Biomimetic Cartilage-Lubricating Hydrogels |
| title_short | Construction and Tribological Properties of Biomimetic Cartilage-Lubricating Hydrogels |
| title_sort | construction and tribological properties of biomimetic cartilage lubricating hydrogels |
| topic | articular cartilage osteoarthritis cartilage replacement polyvinyl alcohol hydrogels lubrication |
| url | https://www.mdpi.com/2310-2861/8/7/415 |
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