Pupil-linked phasic arousal predicts a reduction of choice bias across species and decision domains
Decisions are often made by accumulating ambiguous evidence over time. The brain’s arousal systems are activated during such decisions. In previous work in humans, we found that evoked responses of arousal systems during decisions are reported by rapid dilations of the pupil and track a suppression...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
eLife Sciences Publications Ltd
2020-06-01
|
| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/54014 |
| _version_ | 1811201298368823296 |
|---|---|
| author | Jan Willem de Gee Konstantinos Tsetsos Lars Schwabe Anne E Urai David McCormick Matthew J McGinley Tobias H Donner |
| author_facet | Jan Willem de Gee Konstantinos Tsetsos Lars Schwabe Anne E Urai David McCormick Matthew J McGinley Tobias H Donner |
| author_sort | Jan Willem de Gee |
| collection | DOAJ |
| description | Decisions are often made by accumulating ambiguous evidence over time. The brain’s arousal systems are activated during such decisions. In previous work in humans, we found that evoked responses of arousal systems during decisions are reported by rapid dilations of the pupil and track a suppression of biases in the accumulation of decision-relevant evidence (de Gee et al., 2017). Here, we show that this arousal-related suppression in decision bias acts on both conservative and liberal biases, and generalizes from humans to mice, and from perceptual to memory-based decisions. In challenging sound-detection tasks, the impact of spontaneous or experimentally induced choice biases was reduced under high phasic arousal. Similar bias suppression occurred when evidence was drawn from memory. All of these behavioral effects were explained by reduced evidence accumulation biases. Our results point to a general principle of interplay between phasic arousal and decision-making. |
| first_indexed | 2024-04-12T02:19:39Z |
| format | Article |
| id | doaj.art-1063fd0eae2c45208d8f726e7c174e9d |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T02:19:39Z |
| publishDate | 2020-06-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-1063fd0eae2c45208d8f726e7c174e9d2022-12-22T03:52:09ZengeLife Sciences Publications LtdeLife2050-084X2020-06-01910.7554/eLife.54014Pupil-linked phasic arousal predicts a reduction of choice bias across species and decision domainsJan Willem de Gee0https://orcid.org/0000-0002-5875-8282Konstantinos Tsetsos1https://orcid.org/0000-0003-2709-7634Lars Schwabe2https://orcid.org/0000-0003-4429-4373Anne E Urai3https://orcid.org/0000-0001-5270-6513David McCormick4Matthew J McGinley5Tobias H Donner6https://orcid.org/0000-0002-7559-6019Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Psychology, University of Amsterdam, Amsterdam, Netherlands; Department of Neuroscience, Baylor College of Medicine, Houston, United States; Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital, Houston, United StatesDepartment of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, Hamburg, GermanyDepartment of Cognitive Psychology, Institute of Psychology, Universität Hamburg, Hamburg, GermanyDepartment of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Psychology, University of Amsterdam, Amsterdam, Netherlands; Cold Spring Harbor Laboratory, Cold Spring Harbor, United StatesInstitute of Neuroscience, University of Oregon, Eugene, United States; Department of Neuroscience, Yale University, New Haven, United StatesDepartment of Neuroscience, Baylor College of Medicine, Houston, United States; Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital, Houston, United States; Department of Neuroscience, Yale University, New Haven, United StatesDepartment of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Psychology, University of Amsterdam, Amsterdam, Netherlands; Amsterdam Brain and Cognition, University of Amsterdam, Amsterdam, NetherlandsDecisions are often made by accumulating ambiguous evidence over time. The brain’s arousal systems are activated during such decisions. In previous work in humans, we found that evoked responses of arousal systems during decisions are reported by rapid dilations of the pupil and track a suppression of biases in the accumulation of decision-relevant evidence (de Gee et al., 2017). Here, we show that this arousal-related suppression in decision bias acts on both conservative and liberal biases, and generalizes from humans to mice, and from perceptual to memory-based decisions. In challenging sound-detection tasks, the impact of spontaneous or experimentally induced choice biases was reduced under high phasic arousal. Similar bias suppression occurred when evidence was drawn from memory. All of these behavioral effects were explained by reduced evidence accumulation biases. Our results point to a general principle of interplay between phasic arousal and decision-making.https://elifesciences.org/articles/54014pupilarousalbehavioral modelingdecision-makingbias |
| spellingShingle | Jan Willem de Gee Konstantinos Tsetsos Lars Schwabe Anne E Urai David McCormick Matthew J McGinley Tobias H Donner Pupil-linked phasic arousal predicts a reduction of choice bias across species and decision domains eLife pupil arousal behavioral modeling decision-making bias |
| title | Pupil-linked phasic arousal predicts a reduction of choice bias across species and decision domains |
| title_full | Pupil-linked phasic arousal predicts a reduction of choice bias across species and decision domains |
| title_fullStr | Pupil-linked phasic arousal predicts a reduction of choice bias across species and decision domains |
| title_full_unstemmed | Pupil-linked phasic arousal predicts a reduction of choice bias across species and decision domains |
| title_short | Pupil-linked phasic arousal predicts a reduction of choice bias across species and decision domains |
| title_sort | pupil linked phasic arousal predicts a reduction of choice bias across species and decision domains |
| topic | pupil arousal behavioral modeling decision-making bias |
| url | https://elifesciences.org/articles/54014 |
| work_keys_str_mv | AT janwillemdegee pupillinkedphasicarousalpredictsareductionofchoicebiasacrossspeciesanddecisiondomains AT konstantinostsetsos pupillinkedphasicarousalpredictsareductionofchoicebiasacrossspeciesanddecisiondomains AT larsschwabe pupillinkedphasicarousalpredictsareductionofchoicebiasacrossspeciesanddecisiondomains AT anneeurai pupillinkedphasicarousalpredictsareductionofchoicebiasacrossspeciesanddecisiondomains AT davidmccormick pupillinkedphasicarousalpredictsareductionofchoicebiasacrossspeciesanddecisiondomains AT matthewjmcginley pupillinkedphasicarousalpredictsareductionofchoicebiasacrossspeciesanddecisiondomains AT tobiashdonner pupillinkedphasicarousalpredictsareductionofchoicebiasacrossspeciesanddecisiondomains |