Diffuse Imaging Approach for Universal Noninvasive Blood Glucose Measurements
We proposed a diffuse imaging approach for universal noninvasive blood glucose measurements based on visible light, which can predict the blood glucose concentration without personal calibration. The proposed approach used a CCD to obtain diffuse images from human index finger pulp. The denoising au...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-03-01
|
| Series: | Frontiers in Physics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphy.2022.853266/full |
| _version_ | 1819178058315202560 |
|---|---|
| author | Ming Liu Ming Liu Ming Liu Ge Xu Ge Xu Yuejin Zhao Yuejin Zhao Yuejin Zhao Lingqin Kong Lingqin Kong Lingqin Kong Liquan Dong Liquan Dong Liquan Dong Fen Li Fen Li Fen Li Mei Hui Mei Hui |
| author_facet | Ming Liu Ming Liu Ming Liu Ge Xu Ge Xu Yuejin Zhao Yuejin Zhao Yuejin Zhao Lingqin Kong Lingqin Kong Lingqin Kong Liquan Dong Liquan Dong Liquan Dong Fen Li Fen Li Fen Li Mei Hui Mei Hui |
| author_sort | Ming Liu |
| collection | DOAJ |
| description | We proposed a diffuse imaging approach for universal noninvasive blood glucose measurements based on visible light, which can predict the blood glucose concentration without personal calibration. The proposed approach used a CCD to obtain diffuse images from human index finger pulp. The denoising autoencoder algorithm adopted effectively extracted the scattering information highly related to blood glucose concentration from the diffuse images, and the gradient boosting regression algorithm enabled an accurate calculation of blood glucose concentration without prior personalized calibration. In vivo experimental results showed that the proposed approach had a mean absolute error of 19.44 mg/dl, with all the predicted results observed within the clinically acceptable region (Region A: 78.9%) in the Clarke error grid analysis. Compared to other blood glucose concentration measurement methods of scattering coefficient, this new method does not require individual calibration, therefore it is easier to implement and popularize, which is critical for the noninvasive monitoring of blood glucose concentration. |
| first_indexed | 2024-12-22T21:36:31Z |
| format | Article |
| id | doaj.art-106aba012b064c93b1af353ca532148e |
| institution | Directory Open Access Journal |
| issn | 2296-424X |
| language | English |
| last_indexed | 2024-12-22T21:36:31Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physics |
| spelling | doaj.art-106aba012b064c93b1af353ca532148e2022-12-21T18:11:43ZengFrontiers Media S.A.Frontiers in Physics2296-424X2022-03-011010.3389/fphy.2022.853266853266Diffuse Imaging Approach for Universal Noninvasive Blood Glucose MeasurementsMing Liu0Ming Liu1Ming Liu2Ge Xu3Ge Xu4Yuejin Zhao5Yuejin Zhao6Yuejin Zhao7Lingqin Kong8Lingqin Kong9Lingqin Kong10Liquan Dong11Liquan Dong12Liquan Dong13Fen Li14Fen Li15Fen Li16Mei Hui17Mei Hui18School of Optics and Photonics, Beijing Institute of Technology, Beijing, ChinaBeijing Key Laboratory for Precision Optoelectronic Measurement Instrument and Technology, Beijing, ChinaYangtze Delta Region Academy of Beijing Institute of Technology, Jiaxing, ChinaSchool of Optics and Photonics, Beijing Institute of Technology, Beijing, ChinaBeijing Key Laboratory for Precision Optoelectronic Measurement Instrument and Technology, Beijing, ChinaSchool of Optics and Photonics, Beijing Institute of Technology, Beijing, ChinaBeijing Key Laboratory for Precision Optoelectronic Measurement Instrument and Technology, Beijing, ChinaYangtze Delta Region Academy of Beijing Institute of Technology, Jiaxing, ChinaSchool of Optics and Photonics, Beijing Institute of Technology, Beijing, ChinaBeijing Key Laboratory for Precision Optoelectronic Measurement Instrument and Technology, Beijing, ChinaYangtze Delta Region Academy of Beijing Institute of Technology, Jiaxing, ChinaSchool of Optics and Photonics, Beijing Institute of Technology, Beijing, ChinaBeijing Key Laboratory for Precision Optoelectronic Measurement Instrument and Technology, Beijing, ChinaYangtze Delta Region Academy of Beijing Institute of Technology, Jiaxing, ChinaSchool of Optics and Photonics, Beijing Institute of Technology, Beijing, ChinaBeijing Key Laboratory for Precision Optoelectronic Measurement Instrument and Technology, Beijing, ChinaNational Astronomical Observatories, Chinese Academy of Science, Beijing, ChinaSchool of Optics and Photonics, Beijing Institute of Technology, Beijing, ChinaBeijing Key Laboratory for Precision Optoelectronic Measurement Instrument and Technology, Beijing, ChinaWe proposed a diffuse imaging approach for universal noninvasive blood glucose measurements based on visible light, which can predict the blood glucose concentration without personal calibration. The proposed approach used a CCD to obtain diffuse images from human index finger pulp. The denoising autoencoder algorithm adopted effectively extracted the scattering information highly related to blood glucose concentration from the diffuse images, and the gradient boosting regression algorithm enabled an accurate calculation of blood glucose concentration without prior personalized calibration. In vivo experimental results showed that the proposed approach had a mean absolute error of 19.44 mg/dl, with all the predicted results observed within the clinically acceptable region (Region A: 78.9%) in the Clarke error grid analysis. Compared to other blood glucose concentration measurement methods of scattering coefficient, this new method does not require individual calibration, therefore it is easier to implement and popularize, which is critical for the noninvasive monitoring of blood glucose concentration.https://www.frontiersin.org/articles/10.3389/fphy.2022.853266/fullnoninvasive blood glucose concentration monitoringdiffuse imagescattering coefficientgradient boosting regressiondeep feature |
| spellingShingle | Ming Liu Ming Liu Ming Liu Ge Xu Ge Xu Yuejin Zhao Yuejin Zhao Yuejin Zhao Lingqin Kong Lingqin Kong Lingqin Kong Liquan Dong Liquan Dong Liquan Dong Fen Li Fen Li Fen Li Mei Hui Mei Hui Diffuse Imaging Approach for Universal Noninvasive Blood Glucose Measurements Frontiers in Physics noninvasive blood glucose concentration monitoring diffuse image scattering coefficient gradient boosting regression deep feature |
| title | Diffuse Imaging Approach for Universal Noninvasive Blood Glucose Measurements |
| title_full | Diffuse Imaging Approach for Universal Noninvasive Blood Glucose Measurements |
| title_fullStr | Diffuse Imaging Approach for Universal Noninvasive Blood Glucose Measurements |
| title_full_unstemmed | Diffuse Imaging Approach for Universal Noninvasive Blood Glucose Measurements |
| title_short | Diffuse Imaging Approach for Universal Noninvasive Blood Glucose Measurements |
| title_sort | diffuse imaging approach for universal noninvasive blood glucose measurements |
| topic | noninvasive blood glucose concentration monitoring diffuse image scattering coefficient gradient boosting regression deep feature |
| url | https://www.frontiersin.org/articles/10.3389/fphy.2022.853266/full |
| work_keys_str_mv | AT mingliu diffuseimagingapproachforuniversalnoninvasivebloodglucosemeasurements AT mingliu diffuseimagingapproachforuniversalnoninvasivebloodglucosemeasurements AT mingliu diffuseimagingapproachforuniversalnoninvasivebloodglucosemeasurements AT gexu diffuseimagingapproachforuniversalnoninvasivebloodglucosemeasurements AT gexu diffuseimagingapproachforuniversalnoninvasivebloodglucosemeasurements AT yuejinzhao diffuseimagingapproachforuniversalnoninvasivebloodglucosemeasurements AT yuejinzhao diffuseimagingapproachforuniversalnoninvasivebloodglucosemeasurements AT yuejinzhao diffuseimagingapproachforuniversalnoninvasivebloodglucosemeasurements AT lingqinkong diffuseimagingapproachforuniversalnoninvasivebloodglucosemeasurements AT lingqinkong diffuseimagingapproachforuniversalnoninvasivebloodglucosemeasurements AT lingqinkong diffuseimagingapproachforuniversalnoninvasivebloodglucosemeasurements AT liquandong diffuseimagingapproachforuniversalnoninvasivebloodglucosemeasurements AT liquandong diffuseimagingapproachforuniversalnoninvasivebloodglucosemeasurements AT liquandong diffuseimagingapproachforuniversalnoninvasivebloodglucosemeasurements AT fenli diffuseimagingapproachforuniversalnoninvasivebloodglucosemeasurements AT fenli diffuseimagingapproachforuniversalnoninvasivebloodglucosemeasurements AT fenli diffuseimagingapproachforuniversalnoninvasivebloodglucosemeasurements AT meihui diffuseimagingapproachforuniversalnoninvasivebloodglucosemeasurements AT meihui diffuseimagingapproachforuniversalnoninvasivebloodglucosemeasurements |