Human Milk Feeding Is Associated with Decreased Incidence of Moderate-Severe Bronchopulmonary Dysplasia in Extremely Preterm Infants
Background: An increased rate of bronchopulmonary dysplasia (BPD) is reported in extremely preterm infants. A potential role of human milk feeding in protecting against this condition has been suggested. Methods: A retrospective descriptive study was conducted based on data about morbidity in the po...
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| Format: | Article |
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MDPI AG
2023-07-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/10/7/1267 |
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| author | Sergio Verd Roser Porta Gemma Ginovart Alejandro Avila-Alvarez Fermín García-Muñoz Rodrigo Montserrat Izquierdo Renau Paula Sol Ventura |
| author_facet | Sergio Verd Roser Porta Gemma Ginovart Alejandro Avila-Alvarez Fermín García-Muñoz Rodrigo Montserrat Izquierdo Renau Paula Sol Ventura |
| author_sort | Sergio Verd |
| collection | DOAJ |
| description | Background: An increased rate of bronchopulmonary dysplasia (BPD) is reported in extremely preterm infants. A potential role of human milk feeding in protecting against this condition has been suggested. Methods: A retrospective descriptive study was conducted based on data about morbidity in the population of infants born between 22+0 and 26+6 weeks of gestation, included in the Spanish network SEN1500 during the period 2004–2019 and discharged alive. The primary outcome was moderate-severe BPD. Associated conditions were studied, including human milk feeding at discharge. The temporal trends of BPD and human milk feeding rates at discharge were also studied. Results: In the study population of 4341 infants, the rate of moderate-severe BPD was 43.7% and it increased to >50% in the last three years. The factors significantly associated with a higher risk of moderate-severe BPD were birth weight, male sex, high-frequency oscillatory ventilation, duration of invasive mechanical ventilation, inhaled nitric oxide, patent ductus arteriosus, and late-onset sepsis. Exclusive human milk feeding and any amount of human milk at discharge were associated with a lower incidence of moderate-severe BPD (OR 0.752, 95% CI 0.629–0.901 and OR 0.714, 95% CI 0.602–0.847, respectively). During the study period, the proportion of infants with moderate-severe BPD fed any amount of human milk at discharge increased more than twofold. And the proportion of infants with moderate-severe BPD who were exclusively fed human milk at discharge increased at the same rate. Conclusions: Our work shows an inverse relationship between human milk feeding at discharge from the neonatal unit and the occurrence of BPD. |
| first_indexed | 2024-03-11T01:11:20Z |
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| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-11T01:11:20Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-106bd4aa2a2d4e529e8f2c368397519a2023-11-18T18:50:37ZengMDPI AGChildren2227-90672023-07-01107126710.3390/children10071267Human Milk Feeding Is Associated with Decreased Incidence of Moderate-Severe Bronchopulmonary Dysplasia in Extremely Preterm InfantsSergio Verd0Roser Porta1Gemma Ginovart2Alejandro Avila-Alvarez3Fermín García-Muñoz Rodrigo4Montserrat Izquierdo Renau5Paula Sol Ventura6Department of Pediatric Care Primary Unit, La Vileta Surgery, Health Sciences Research Institute (IUNICS), Balearic University, 07122 Palma, SpainDepartment of Pediatrics, Division of Neonatology, Hospital Universitari Germans Trias i Pujol, Badalona, Universitat Autònoma de Barcelona, 08193 Bellaterra, SpainDepartment of Pediatrics, Division of Neonatology, Hospital Universitari Germans Trias i Pujol, Badalona, Universitat Autònoma de Barcelona, 08193 Bellaterra, SpainDivision of Neonatology, Complexo Hospitalario Universitario de A Coruña (CHUAC), SERGAS, 15006 A Coruña, SpainDivision of Neonatology, Complejo Hospitalario Universitario Insular Materno-Infantil, 35016 Las Palmas, SpainDivision of Neonatology, Hospital Sant Joan de Déu, 07007 Barcelona, SpainDepartment of Pediatrics, Division of Neonatology, Hospital Universitari Germans Trias i Pujol, Badalona, Universitat Autònoma de Barcelona, 08193 Bellaterra, SpainBackground: An increased rate of bronchopulmonary dysplasia (BPD) is reported in extremely preterm infants. A potential role of human milk feeding in protecting against this condition has been suggested. Methods: A retrospective descriptive study was conducted based on data about morbidity in the population of infants born between 22+0 and 26+6 weeks of gestation, included in the Spanish network SEN1500 during the period 2004–2019 and discharged alive. The primary outcome was moderate-severe BPD. Associated conditions were studied, including human milk feeding at discharge. The temporal trends of BPD and human milk feeding rates at discharge were also studied. Results: In the study population of 4341 infants, the rate of moderate-severe BPD was 43.7% and it increased to >50% in the last three years. The factors significantly associated with a higher risk of moderate-severe BPD were birth weight, male sex, high-frequency oscillatory ventilation, duration of invasive mechanical ventilation, inhaled nitric oxide, patent ductus arteriosus, and late-onset sepsis. Exclusive human milk feeding and any amount of human milk at discharge were associated with a lower incidence of moderate-severe BPD (OR 0.752, 95% CI 0.629–0.901 and OR 0.714, 95% CI 0.602–0.847, respectively). During the study period, the proportion of infants with moderate-severe BPD fed any amount of human milk at discharge increased more than twofold. And the proportion of infants with moderate-severe BPD who were exclusively fed human milk at discharge increased at the same rate. Conclusions: Our work shows an inverse relationship between human milk feeding at discharge from the neonatal unit and the occurrence of BPD.https://www.mdpi.com/2227-9067/10/7/1267bronchopulmonary dysplasiahuman milk feedingbreastfeedingextremely preterm |
| spellingShingle | Sergio Verd Roser Porta Gemma Ginovart Alejandro Avila-Alvarez Fermín García-Muñoz Rodrigo Montserrat Izquierdo Renau Paula Sol Ventura Human Milk Feeding Is Associated with Decreased Incidence of Moderate-Severe Bronchopulmonary Dysplasia in Extremely Preterm Infants Children bronchopulmonary dysplasia human milk feeding breastfeeding extremely preterm |
| title | Human Milk Feeding Is Associated with Decreased Incidence of Moderate-Severe Bronchopulmonary Dysplasia in Extremely Preterm Infants |
| title_full | Human Milk Feeding Is Associated with Decreased Incidence of Moderate-Severe Bronchopulmonary Dysplasia in Extremely Preterm Infants |
| title_fullStr | Human Milk Feeding Is Associated with Decreased Incidence of Moderate-Severe Bronchopulmonary Dysplasia in Extremely Preterm Infants |
| title_full_unstemmed | Human Milk Feeding Is Associated with Decreased Incidence of Moderate-Severe Bronchopulmonary Dysplasia in Extremely Preterm Infants |
| title_short | Human Milk Feeding Is Associated with Decreased Incidence of Moderate-Severe Bronchopulmonary Dysplasia in Extremely Preterm Infants |
| title_sort | human milk feeding is associated with decreased incidence of moderate severe bronchopulmonary dysplasia in extremely preterm infants |
| topic | bronchopulmonary dysplasia human milk feeding breastfeeding extremely preterm |
| url | https://www.mdpi.com/2227-9067/10/7/1267 |
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