Structural and mutational analysis of MazE6-operator DNA complex provide insights into autoregulation of toxin-antitoxin systems
The dimeric MazE6 antitoxin binds to a specific sequence in its cognate operator DNA for autoregulation, and the key residues for dimerization and DNA binding are identified.
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-09-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-022-03933-5 |
| _version_ | 1798036349659381760 |
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| author | Khushboo Kumari Siddhartha P. Sarma |
| author_facet | Khushboo Kumari Siddhartha P. Sarma |
| author_sort | Khushboo Kumari |
| collection | DOAJ |
| description | The dimeric MazE6 antitoxin binds to a specific sequence in its cognate operator DNA for autoregulation, and the key residues for dimerization and DNA binding are identified. |
| first_indexed | 2024-04-11T21:11:38Z |
| format | Article |
| id | doaj.art-106eb1ec7e434bb3a1cfe8573d17b492 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-04-11T21:11:38Z |
| publishDate | 2022-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-106eb1ec7e434bb3a1cfe8573d17b4922022-12-22T04:03:00ZengNature PortfolioCommunications Biology2399-36422022-09-015111410.1038/s42003-022-03933-5Structural and mutational analysis of MazE6-operator DNA complex provide insights into autoregulation of toxin-antitoxin systemsKhushboo Kumari0Siddhartha P. Sarma1Molecular Biophysics Unit, Indian Institute of ScienceMolecular Biophysics Unit, Indian Institute of ScienceThe dimeric MazE6 antitoxin binds to a specific sequence in its cognate operator DNA for autoregulation, and the key residues for dimerization and DNA binding are identified.https://doi.org/10.1038/s42003-022-03933-5 |
| spellingShingle | Khushboo Kumari Siddhartha P. Sarma Structural and mutational analysis of MazE6-operator DNA complex provide insights into autoregulation of toxin-antitoxin systems Communications Biology |
| title | Structural and mutational analysis of MazE6-operator DNA complex provide insights into autoregulation of toxin-antitoxin systems |
| title_full | Structural and mutational analysis of MazE6-operator DNA complex provide insights into autoregulation of toxin-antitoxin systems |
| title_fullStr | Structural and mutational analysis of MazE6-operator DNA complex provide insights into autoregulation of toxin-antitoxin systems |
| title_full_unstemmed | Structural and mutational analysis of MazE6-operator DNA complex provide insights into autoregulation of toxin-antitoxin systems |
| title_short | Structural and mutational analysis of MazE6-operator DNA complex provide insights into autoregulation of toxin-antitoxin systems |
| title_sort | structural and mutational analysis of maze6 operator dna complex provide insights into autoregulation of toxin antitoxin systems |
| url | https://doi.org/10.1038/s42003-022-03933-5 |
| work_keys_str_mv | AT khushbookumari structuralandmutationalanalysisofmaze6operatordnacomplexprovideinsightsintoautoregulationoftoxinantitoxinsystems AT siddharthapsarma structuralandmutationalanalysisofmaze6operatordnacomplexprovideinsightsintoautoregulationoftoxinantitoxinsystems |