Tunable drug loading and release from blended chitosan/silk fibroin-based daily disposable contact lenses
Recently, chitosan/regenerated silk fibroin (CS/SF) films have been developed for daily disposable contact lenses. This study further explored the versatility of using CS/SF films in contact-lens-based ophthalmic delivery for multiple charged drugs. The selected model drugs, the negatively charged...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Prince of Songkla University
2022-10-01
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| Series: | Songklanakarin Journal of Science and Technology (SJST) |
| Subjects: | |
| Online Access: | https://sjst.psu.ac.th/journal/44-5/28.pdf |
| _version_ | 1827959973142855680 |
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| author | Rachasit Jeencham Martin Humenik Manote Sutheerawattananonda Duy Toan Pham Waree Tiyaboonchai |
| author_facet | Rachasit Jeencham Martin Humenik Manote Sutheerawattananonda Duy Toan Pham Waree Tiyaboonchai |
| author_sort | Rachasit Jeencham |
| collection | DOAJ |
| description | Recently, chitosan/regenerated silk fibroin (CS/SF) films have been developed for daily disposable contact lenses. This
study further explored the versatility of using CS/SF films in contact-lens-based ophthalmic delivery for multiple charged drugs.
The selected model drugs, the negatively charged 5(6)-carboxyfluorescein (CF), the zwitterion rhodamine B (RB), and the noncharged acetaminophen (APAP), were individually loaded into the CS/RSF films by soaking. The non-charged APAP could
not be loaded into the CS/SF films, whereas the charged CF and RB were successfully loaded. The drug loading capacity
increased with soaking time and reached its equilibrium at 3 h. Furthermore, the drug loading capacity and release characteristics
could be controlled by adjusting the CS/SF ratio in the film, which is useful for tailoring various treatments. The loading capacity
and release duration of the negatively charged CF increased with CS content, while those of the zwitterion RB increased with
SF content. In addition, a prolonged drug release exceeding 12 h could be obtained for both drugs. In summary, the CS/SF films
are promising biomaterials for contact-lens-based ophthalmic delivery of various charged drugs, which is beneficial for reducing
the drug side effects and administration frequency.
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| first_indexed | 2024-04-09T16:01:25Z |
| format | Article |
| id | doaj.art-106eb255d3bd40dfa4e84d944cdeb523 |
| institution | Directory Open Access Journal |
| issn | 0125-3395 |
| language | English |
| last_indexed | 2024-04-09T16:01:25Z |
| publishDate | 2022-10-01 |
| publisher | Prince of Songkla University |
| record_format | Article |
| series | Songklanakarin Journal of Science and Technology (SJST) |
| spelling | doaj.art-106eb255d3bd40dfa4e84d944cdeb5232023-04-25T09:59:02ZengPrince of Songkla UniversitySongklanakarin Journal of Science and Technology (SJST)0125-33952022-10-014451373138010.14456/sjst-psu.2022.178Tunable drug loading and release from blended chitosan/silk fibroin-based daily disposable contact lensesRachasit Jeencham0Martin Humenik1Manote Sutheerawattananonda2Duy Toan Pham3Waree Tiyaboonchai4Faculty of Pharmaceutical Sciences, Naresuan University, Mueang, Phitsanulok, 65000 ThailandDepartment of Biomaterials, Faculty of Engineering Science, Universität Bayreuth, Bayreuth, 95447 GermanySchool of Food Technology, Institute of Agricultural Technology, Suranaree University of Technology, Mueang, Nakhon Ratchasima, 30000 ThailandDepartment of Chemistry, College of Natural Sciences, Can Tho University, Can Tho, 900000 VietnamFaculty of Pharmaceutical Sciences, Naresuan University, Mueang, Phitsanulok, 65000 ThailandRecently, chitosan/regenerated silk fibroin (CS/SF) films have been developed for daily disposable contact lenses. This study further explored the versatility of using CS/SF films in contact-lens-based ophthalmic delivery for multiple charged drugs. The selected model drugs, the negatively charged 5(6)-carboxyfluorescein (CF), the zwitterion rhodamine B (RB), and the noncharged acetaminophen (APAP), were individually loaded into the CS/RSF films by soaking. The non-charged APAP could not be loaded into the CS/SF films, whereas the charged CF and RB were successfully loaded. The drug loading capacity increased with soaking time and reached its equilibrium at 3 h. Furthermore, the drug loading capacity and release characteristics could be controlled by adjusting the CS/SF ratio in the film, which is useful for tailoring various treatments. The loading capacity and release duration of the negatively charged CF increased with CS content, while those of the zwitterion RB increased with SF content. In addition, a prolonged drug release exceeding 12 h could be obtained for both drugs. In summary, the CS/SF films are promising biomaterials for contact-lens-based ophthalmic delivery of various charged drugs, which is beneficial for reducing the drug side effects and administration frequency. https://sjst.psu.ac.th/journal/44-5/28.pdftunable drug releasecontact lenseschitosansilk fibroin |
| spellingShingle | Rachasit Jeencham Martin Humenik Manote Sutheerawattananonda Duy Toan Pham Waree Tiyaboonchai Tunable drug loading and release from blended chitosan/silk fibroin-based daily disposable contact lenses Songklanakarin Journal of Science and Technology (SJST) tunable drug release contact lenses chitosan silk fibroin |
| title | Tunable drug loading and release from blended chitosan/silk fibroin-based daily disposable contact lenses |
| title_full | Tunable drug loading and release from blended chitosan/silk fibroin-based daily disposable contact lenses |
| title_fullStr | Tunable drug loading and release from blended chitosan/silk fibroin-based daily disposable contact lenses |
| title_full_unstemmed | Tunable drug loading and release from blended chitosan/silk fibroin-based daily disposable contact lenses |
| title_short | Tunable drug loading and release from blended chitosan/silk fibroin-based daily disposable contact lenses |
| title_sort | tunable drug loading and release from blended chitosan silk fibroin based daily disposable contact lenses |
| topic | tunable drug release contact lenses chitosan silk fibroin |
| url | https://sjst.psu.ac.th/journal/44-5/28.pdf |
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