A conserved strategy for inducing appendage regeneration in moon jellyfish, Drosophila, and mice
Can limb regeneration be induced? Few have pursued this question, and an evolutionarily conserved strategy has yet to emerge. This study reports a strategy for inducing regenerative response in appendages, which works across three species that span the animal phylogeny. In Cnidaria, the frequency of...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2021-12-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/65092 |
| _version_ | 1797797510827212800 |
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| author | Michael J Abrams Fayth Hui Tan Yutian Li Ty Basinger Martin L Heithe Anish Sarma Iris T Lee Zevin J Condiotte Misha Raffiee John O Dabiri David A Gold Lea Goentoro |
| author_facet | Michael J Abrams Fayth Hui Tan Yutian Li Ty Basinger Martin L Heithe Anish Sarma Iris T Lee Zevin J Condiotte Misha Raffiee John O Dabiri David A Gold Lea Goentoro |
| author_sort | Michael J Abrams |
| collection | DOAJ |
| description | Can limb regeneration be induced? Few have pursued this question, and an evolutionarily conserved strategy has yet to emerge. This study reports a strategy for inducing regenerative response in appendages, which works across three species that span the animal phylogeny. In Cnidaria, the frequency of appendage regeneration in the moon jellyfish Aurelia was increased by feeding with the amino acid L-leucine and the growth hormone insulin. In insects, the same strategy induced tibia regeneration in adult Drosophila. Finally, in mammals, L-leucine and sucrose administration induced digit regeneration in adult mice, including dramatically from mid-phalangeal amputation. The conserved effect of L-leucine and insulin/sugar suggests a key role for energetic parameters in regeneration induction. The simplicity by which nutrient supplementation can induce appendage regeneration provides a testable hypothesis across animals. |
| first_indexed | 2024-03-13T03:49:27Z |
| format | Article |
| id | doaj.art-106f3abfc79e439da9259e61100e3ade |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-03-13T03:49:27Z |
| publishDate | 2021-12-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-106f3abfc79e439da9259e61100e3ade2023-06-22T15:38:05ZengeLife Sciences Publications LtdeLife2050-084X2021-12-011010.7554/eLife.65092A conserved strategy for inducing appendage regeneration in moon jellyfish, Drosophila, and miceMichael J Abrams0Fayth Hui Tan1Yutian Li2https://orcid.org/0000-0001-8151-3518Ty Basinger3Martin L Heithe4Anish Sarma5Iris T Lee6Zevin J Condiotte7Misha Raffiee8John O Dabiri9David A Gold10Lea Goentoro11https://orcid.org/0000-0002-3904-0195Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, United StatesDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, United StatesDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, United StatesDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, United StatesDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, United StatesDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, United StatesDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, United StatesDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, United StatesDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, United StatesGraduate Aerospace Laboratories and Mechanical Engineering, California Institute of Technology, Pasadena, United StatesDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, United StatesDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, United StatesCan limb regeneration be induced? Few have pursued this question, and an evolutionarily conserved strategy has yet to emerge. This study reports a strategy for inducing regenerative response in appendages, which works across three species that span the animal phylogeny. In Cnidaria, the frequency of appendage regeneration in the moon jellyfish Aurelia was increased by feeding with the amino acid L-leucine and the growth hormone insulin. In insects, the same strategy induced tibia regeneration in adult Drosophila. Finally, in mammals, L-leucine and sucrose administration induced digit regeneration in adult mice, including dramatically from mid-phalangeal amputation. The conserved effect of L-leucine and insulin/sugar suggests a key role for energetic parameters in regeneration induction. The simplicity by which nutrient supplementation can induce appendage regeneration provides a testable hypothesis across animals.https://elifesciences.org/articles/65092appendage regenerationlimb regenerationleucineinsulinsucrose |
| spellingShingle | Michael J Abrams Fayth Hui Tan Yutian Li Ty Basinger Martin L Heithe Anish Sarma Iris T Lee Zevin J Condiotte Misha Raffiee John O Dabiri David A Gold Lea Goentoro A conserved strategy for inducing appendage regeneration in moon jellyfish, Drosophila, and mice eLife appendage regeneration limb regeneration leucine insulin sucrose |
| title | A conserved strategy for inducing appendage regeneration in moon jellyfish, Drosophila, and mice |
| title_full | A conserved strategy for inducing appendage regeneration in moon jellyfish, Drosophila, and mice |
| title_fullStr | A conserved strategy for inducing appendage regeneration in moon jellyfish, Drosophila, and mice |
| title_full_unstemmed | A conserved strategy for inducing appendage regeneration in moon jellyfish, Drosophila, and mice |
| title_short | A conserved strategy for inducing appendage regeneration in moon jellyfish, Drosophila, and mice |
| title_sort | conserved strategy for inducing appendage regeneration in moon jellyfish drosophila and mice |
| topic | appendage regeneration limb regeneration leucine insulin sucrose |
| url | https://elifesciences.org/articles/65092 |
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