Klf5 suppresses ERK signaling in mouse pluripotent stem cells.

Klf5 suppresses ERK signaling in mouse pluripotent stem cells.

Mouse embryonic stem cells (ESCs) are pluripotent stem cells, which have the ability to differentiate into all three germ layers: mesoderm, endoderm, and ectoderm. Proper levels of phosphorylated extracellular signal-regulated kinase (pERK) are critical for maintaining pluripotency, as elevated pERK...

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Bibliographic Details
Main Authors: Takuya Azami, Ken Matsumoto, Hyojung Jeon, Tsuyoshi Waku, Masafumi Muratani, Hitoshi Niwa, Satoru Takahashi, Masatsugu Ema
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6242311?pdf=render

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