Functional Roles of Chemokine Receptor CCR2 and Its Ligands in Liver Disease
Chemokines are a family of cytokines that orchestrate the migration and positioning of immune cells within tissues and are critical for the function of the immune system. CCR2 participates in liver pathology, including acute liver injury, chronic hepatitis, fibrosis/cirrhosis, and tumor progression,...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-02-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.812431/full |
| _version_ | 1818323041672757248 |
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| author | Shaoping She Liying Ren Pu Chen Mingyang Wang Dongbo Chen Ying Wang Hongsong Chen |
| author_facet | Shaoping She Liying Ren Pu Chen Mingyang Wang Dongbo Chen Ying Wang Hongsong Chen |
| author_sort | Shaoping She |
| collection | DOAJ |
| description | Chemokines are a family of cytokines that orchestrate the migration and positioning of immune cells within tissues and are critical for the function of the immune system. CCR2 participates in liver pathology, including acute liver injury, chronic hepatitis, fibrosis/cirrhosis, and tumor progression, by mediating the recruitment of immune cells to inflammation and tumor sites. Although a variety of chemokines have been well studied in various diseases, there is no comprehensive review presenting the roles of all known chemokine ligands of CCR2 (CCL2, CCL7, CCL8, CCL12, CCL13, CCL16, and PSMP) in liver disease, and this review aims to fill this gap. The introduction of each chemokine includes its discovery, its corresponding chemotactic receptors, physiological functions and roles in inflammation and tumors, and its impact on different immune cell subgroups. |
| first_indexed | 2024-12-13T11:06:23Z |
| format | Article |
| id | doaj.art-107342c702864d068112decb5e8bbf23 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-13T11:06:23Z |
| publishDate | 2022-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-107342c702864d068112decb5e8bbf232022-12-21T23:48:58ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-02-011310.3389/fimmu.2022.812431812431Functional Roles of Chemokine Receptor CCR2 and Its Ligands in Liver DiseaseShaoping She0Liying Ren1Pu Chen2Mingyang Wang3Dongbo Chen4Ying Wang5Hongsong Chen6Peking University Hepatology Institute, Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases, Peking University People’s Hospital, Beijing, ChinaLaboratory of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital of Guilin Medical University, Guilin, ChinaPeking University Hepatology Institute, Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases, Peking University People’s Hospital, Beijing, ChinaState Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, ChinaPeking University Hepatology Institute, Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases, Peking University People’s Hospital, Beijing, ChinaDepartment of Immunology, School of Basic Medical Sciences, and NHC Key Laboratory of Medical Immunology, Peking University, Beijing, ChinaPeking University Hepatology Institute, Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases, Peking University People’s Hospital, Beijing, ChinaChemokines are a family of cytokines that orchestrate the migration and positioning of immune cells within tissues and are critical for the function of the immune system. CCR2 participates in liver pathology, including acute liver injury, chronic hepatitis, fibrosis/cirrhosis, and tumor progression, by mediating the recruitment of immune cells to inflammation and tumor sites. Although a variety of chemokines have been well studied in various diseases, there is no comprehensive review presenting the roles of all known chemokine ligands of CCR2 (CCL2, CCL7, CCL8, CCL12, CCL13, CCL16, and PSMP) in liver disease, and this review aims to fill this gap. The introduction of each chemokine includes its discovery, its corresponding chemotactic receptors, physiological functions and roles in inflammation and tumors, and its impact on different immune cell subgroups.https://www.frontiersin.org/articles/10.3389/fimmu.2022.812431/fullchemokineCCR2CCL2PSMPhepatocellular carcinomamacrophage |
| spellingShingle | Shaoping She Liying Ren Pu Chen Mingyang Wang Dongbo Chen Ying Wang Hongsong Chen Functional Roles of Chemokine Receptor CCR2 and Its Ligands in Liver Disease Frontiers in Immunology chemokine CCR2 CCL2 PSMP hepatocellular carcinoma macrophage |
| title | Functional Roles of Chemokine Receptor CCR2 and Its Ligands in Liver Disease |
| title_full | Functional Roles of Chemokine Receptor CCR2 and Its Ligands in Liver Disease |
| title_fullStr | Functional Roles of Chemokine Receptor CCR2 and Its Ligands in Liver Disease |
| title_full_unstemmed | Functional Roles of Chemokine Receptor CCR2 and Its Ligands in Liver Disease |
| title_short | Functional Roles of Chemokine Receptor CCR2 and Its Ligands in Liver Disease |
| title_sort | functional roles of chemokine receptor ccr2 and its ligands in liver disease |
| topic | chemokine CCR2 CCL2 PSMP hepatocellular carcinoma macrophage |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.812431/full |
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