Esculetin reverses histone H2A/H2B ubiquitination, H3 dimethylation, acetylation and phosphorylation in preventing type 2 diabetic cardiomyopathy

Esculetin reverses histone H2A/H2B ubiquitination, H3 dimethylation, acetylation and phosphorylation in preventing type 2 diabetic cardiomyopathy

Post translational histone modifications (PTHMs) play a pivotal role in pathogenesis of diabetic complications. Esculetin is reported to prevent glomerulosclerosis by reversing PTHMs in diabetic rats, but until now its cardioprotective role is unexplored. Hence, the present study aimed to investigat...

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Bibliographic Details
Main Authors:	Almesh Kadakol, Vajir Malek, Santosh Kumar Goru, Anuradha Pandey, Anil Bhanudas Gaikwad
Format:	Article
Language:	English
Published:	Elsevier 2015-08-01
Series:	Journal of Functional Foods
Subjects:	Epigenetics Diabetic cardiomyopathy Esculetin Histone H3 and H2 modifications
Online Access:	http://www.sciencedirect.com/science/article/pii/S1756464615002558

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