2D:4D Ratio and its Implications in Medicine
Digit ratios, especially 2D:4D ratio, a potential proxy marker for prenatal androgen exposure shows sexual dimorphism. Existing literature and recent research show accumulating evidence on 2D:4D ratio showing correlations with various phenotypic traits in humans. Ratio of 2D:4D is found to correla...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2016-12-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/9000/21952_CE[Ra]_F(Sh)_%20PF1(RO_VJ)_PFA(NC_AK)_PF2(PAG).pdf |
| Summary: | Digit ratios, especially 2D:4D ratio, a potential proxy marker for prenatal androgen exposure shows sexual dimorphism. Existing literature
and recent research show accumulating evidence on 2D:4D ratio showing correlations with various phenotypic traits in humans. Ratio of
2D:4D is found to correlate negatively to testosterone and positively to oestrogen in the foetus. Interestingly, it is constant since birth and
not influenced by the adult hormone levels. Usually, males have lower ratios when compared to females. Prenatal androgen exposure
and therefore, digit ratios have been reported to be associated with numerical competencies, spatial skills, handedness, cognitive
abilities, academic performance, sperm counts, personalities and prevalence of obesity, migraine, eating disorders, depression, myopia,
autism etc. The authors have attempted to write a brief account on the digit ratios and the dimorphism observed in various physiological,
psychological and behavioural traits. Also, the authors have discussed the relevant molecular basics and the methods of measurement
of digit ratios. |
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| ISSN: | 2249-782X 0973-709X |