Ampullary Adenocarcinoma: A Review of the Mutational Landscape and Implications for Treatment
Ampullary carcinomas represent less than 1% of all gastrointestinal malignancies with an incidence of approximately 6 cases per 1 million. Histologic examination and immunohistochemistry have been traditionally used to categorize ampullary tumors into intestinal, pancreatobiliary or mixed subtypes....
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/15/24/5772 |
| _version_ | 1797381707986370560 |
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| author | Vasileios Tsagkalidis Russell C. Langan Brett L. Ecker |
| author_facet | Vasileios Tsagkalidis Russell C. Langan Brett L. Ecker |
| author_sort | Vasileios Tsagkalidis |
| collection | DOAJ |
| description | Ampullary carcinomas represent less than 1% of all gastrointestinal malignancies with an incidence of approximately 6 cases per 1 million. Histologic examination and immunohistochemistry have been traditionally used to categorize ampullary tumors into intestinal, pancreatobiliary or mixed subtypes. Intestinal-subtype tumors may exhibit improved survival versus the pancreatobiliary subtype, although studies on the prognostic value of immunomorphologic classification have been inconsistent. Genomic classifiers hold the promise of greater reliability, while providing potential targets for precision oncology. Multi-institutional collaboration will be necessary to better understand how molecular classification can guide type and sequencing of multimodality therapy. |
| first_indexed | 2024-03-08T20:55:19Z |
| format | Article |
| id | doaj.art-1077bd03c7ff4e049c8f3069e7af523f |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-08T20:55:19Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-1077bd03c7ff4e049c8f3069e7af523f2023-12-22T13:58:49ZengMDPI AGCancers2072-66942023-12-011524577210.3390/cancers15245772Ampullary Adenocarcinoma: A Review of the Mutational Landscape and Implications for TreatmentVasileios Tsagkalidis0Russell C. Langan1Brett L. Ecker2Division of Surgical Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08901, USADivision of Surgical Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08901, USADivision of Surgical Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08901, USAAmpullary carcinomas represent less than 1% of all gastrointestinal malignancies with an incidence of approximately 6 cases per 1 million. Histologic examination and immunohistochemistry have been traditionally used to categorize ampullary tumors into intestinal, pancreatobiliary or mixed subtypes. Intestinal-subtype tumors may exhibit improved survival versus the pancreatobiliary subtype, although studies on the prognostic value of immunomorphologic classification have been inconsistent. Genomic classifiers hold the promise of greater reliability, while providing potential targets for precision oncology. Multi-institutional collaboration will be necessary to better understand how molecular classification can guide type and sequencing of multimodality therapy.https://www.mdpi.com/2072-6694/15/24/5772ampullaryadenocarcinomaperiampullarymutationstargeted therapy |
| spellingShingle | Vasileios Tsagkalidis Russell C. Langan Brett L. Ecker Ampullary Adenocarcinoma: A Review of the Mutational Landscape and Implications for Treatment Cancers ampullary adenocarcinoma periampullary mutations targeted therapy |
| title | Ampullary Adenocarcinoma: A Review of the Mutational Landscape and Implications for Treatment |
| title_full | Ampullary Adenocarcinoma: A Review of the Mutational Landscape and Implications for Treatment |
| title_fullStr | Ampullary Adenocarcinoma: A Review of the Mutational Landscape and Implications for Treatment |
| title_full_unstemmed | Ampullary Adenocarcinoma: A Review of the Mutational Landscape and Implications for Treatment |
| title_short | Ampullary Adenocarcinoma: A Review of the Mutational Landscape and Implications for Treatment |
| title_sort | ampullary adenocarcinoma a review of the mutational landscape and implications for treatment |
| topic | ampullary adenocarcinoma periampullary mutations targeted therapy |
| url | https://www.mdpi.com/2072-6694/15/24/5772 |
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