Prognostic factors for survival in patients with gastric cancer: Single-centre experience
OBJECTIVE: We aimed to investigate survival outcomes and survival-related prognostic factors in gastric cancer patients who were followed-up or received adjuvant therapy in our center. METHODS: Patients with gastric cancer treated between 2005 and 2016 were evaluated retrospectively. We included 345...
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| Format: | Article |
| Language: | English |
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KARE Publishing
2020-03-01
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| Series: | İstanbul Kuzey Klinikleri |
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| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=nci&un=NCI-73549 |
| _version_ | 1797917845764440064 |
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| author | Gokhan Yaprak Deniz Tataroglu Ozyukseler Bedriye Doğan Melike Pekyürek |
| author_facet | Gokhan Yaprak Deniz Tataroglu Ozyukseler Bedriye Doğan Melike Pekyürek |
| author_sort | Gokhan Yaprak |
| collection | DOAJ |
| description | OBJECTIVE: We aimed to investigate survival outcomes and survival-related prognostic factors in gastric cancer patients who were followed-up or received adjuvant therapy in our center.
METHODS: Patients with gastric cancer treated between 2005 and 2016 were evaluated retrospectively. We included 345 non-metastatic (stage I-III) gastric cancer patients in the study. The clinical, demographic, histologic data of the patients and treatment characteristics were obtained from the patient's files.
RESULTS: While 50 patients were stage I, 94 patients were stage II, 201 patients were stage III. While 221 patients (64%) presenting with serosal or adjacent visceral organ invasion or with involved lymph nodes were treated with adjuvant chemoradiotherapy, 124 patients presenting with early-stage disease were followed after surgery. Median follow up time was 34 months (4–156 months). While the median overall survival (OS) was 51 months, median disease-free survival (DFS) was 35 months. Overall survival and disease-free survival rates for 1st, 3rd and 5th years were 85%, 55%, 45% and 72%, 49%, 38%, respectively. According to univariate analysis, tumor size, T stage (p<0.001), N stage (p<0.001), TNM stage (p<0.001), grade (p<0.001) and presence of lymphovascular invasion (p=0.005) were determined as prognostic factors that affect overall survival significantly. According to the multivariate analysis, only T and N stage (p<0.001) were determined as independent prognostic factors for overall survival.
CONCLUSION: Many different prognostic factors have been defined for gastric cancer. In concordance with the literature, we found T and N stages as prognostic factors in univariate and multivariate analysis. |
| first_indexed | 2024-04-10T13:19:50Z |
| format | Article |
| id | doaj.art-10786e296a1840cd9fd27a4246396649 |
| institution | Directory Open Access Journal |
| issn | 2148-4902 |
| language | English |
| last_indexed | 2024-04-10T13:19:50Z |
| publishDate | 2020-03-01 |
| publisher | KARE Publishing |
| record_format | Article |
| series | İstanbul Kuzey Klinikleri |
| spelling | doaj.art-10786e296a1840cd9fd27a42463966492023-02-15T16:12:05ZengKARE Publishingİstanbul Kuzey Klinikleri2148-49022020-03-017214615210.14744/nci.2019.73549NCI-73549Prognostic factors for survival in patients with gastric cancer: Single-centre experienceGokhan Yaprak0Deniz Tataroglu Ozyukseler1Bedriye Doğan2Melike Pekyürek3Department of Radiation Oncology, University of Health Sciences, Kartal Dr. Lutfi Kırdar Training and Research Hospital, Istanbul, TurkeyDepartment of Medical Oncology, University of Health Sciences, Kartal Dr. Lutfi Kırdar Training and Research Hospital, Istanbul, TurkeyDepartment of Radiation Oncology, University of Health Sciences, Kartal Dr. Lutfi Kırdar Training and Research Hospital, Istanbul, TurkeyDepartment of Radiation Oncology, University of Health Sciences, Kartal Dr. Lutfi Kırdar Training and Research Hospital, Istanbul, TurkeyOBJECTIVE: We aimed to investigate survival outcomes and survival-related prognostic factors in gastric cancer patients who were followed-up or received adjuvant therapy in our center. METHODS: Patients with gastric cancer treated between 2005 and 2016 were evaluated retrospectively. We included 345 non-metastatic (stage I-III) gastric cancer patients in the study. The clinical, demographic, histologic data of the patients and treatment characteristics were obtained from the patient's files. RESULTS: While 50 patients were stage I, 94 patients were stage II, 201 patients were stage III. While 221 patients (64%) presenting with serosal or adjacent visceral organ invasion or with involved lymph nodes were treated with adjuvant chemoradiotherapy, 124 patients presenting with early-stage disease were followed after surgery. Median follow up time was 34 months (4–156 months). While the median overall survival (OS) was 51 months, median disease-free survival (DFS) was 35 months. Overall survival and disease-free survival rates for 1st, 3rd and 5th years were 85%, 55%, 45% and 72%, 49%, 38%, respectively. According to univariate analysis, tumor size, T stage (p<0.001), N stage (p<0.001), TNM stage (p<0.001), grade (p<0.001) and presence of lymphovascular invasion (p=0.005) were determined as prognostic factors that affect overall survival significantly. According to the multivariate analysis, only T and N stage (p<0.001) were determined as independent prognostic factors for overall survival. CONCLUSION: Many different prognostic factors have been defined for gastric cancer. In concordance with the literature, we found T and N stages as prognostic factors in univariate and multivariate analysis.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=nci&un=NCI-73549chemoradiotherapygastric cancer; prognostic factors. |
| spellingShingle | Gokhan Yaprak Deniz Tataroglu Ozyukseler Bedriye Doğan Melike Pekyürek Prognostic factors for survival in patients with gastric cancer: Single-centre experience İstanbul Kuzey Klinikleri chemoradiotherapy gastric cancer; prognostic factors. |
| title | Prognostic factors for survival in patients with gastric cancer: Single-centre experience |
| title_full | Prognostic factors for survival in patients with gastric cancer: Single-centre experience |
| title_fullStr | Prognostic factors for survival in patients with gastric cancer: Single-centre experience |
| title_full_unstemmed | Prognostic factors for survival in patients with gastric cancer: Single-centre experience |
| title_short | Prognostic factors for survival in patients with gastric cancer: Single-centre experience |
| title_sort | prognostic factors for survival in patients with gastric cancer single centre experience |
| topic | chemoradiotherapy gastric cancer; prognostic factors. |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=nci&un=NCI-73549 |
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