The Neuroprotective Effects of GPR4 Inhibition through the Attenuation of Caspase Mediated Apoptotic Cell Death in an MPTP Induced Mouse Model of Parkinson’s Disease

The Neuroprotective Effects of GPR4 Inhibition through the Attenuation of Caspase Mediated Apoptotic Cell Death in an MPTP Induced Mouse Model of Parkinson’s Disease

The proton-activated G protein-coupled receptor (GPCR) 4 (GPR4) is constitutively active at physiological pH, and GPR4 knockout protected dopaminergic neurons from caspase-dependent mitochondria-associated apoptosis. This study explored the role of GPR4 in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrid...

Full description

Bibliographic Details
Main Authors: Md Ezazul Haque, Shofiul Azam, Mahbuba Akther, Duk-Yeon Cho, In-Su Kim, Dong-Kug Choi
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
apoptosis
PARP
caspase 3
neurodegeneration
GPR4 receptor
MPTP
Online Access:https://www.mdpi.com/1422-0067/22/9/4674

Internet

https://www.mdpi.com/1422-0067/22/9/4674

Similar Items