Alteration of Extracellular Superoxide Dismutase in Idiopathic Pulmonary Arterial Hypertension
Background: Superoxide dismutases (SODs) are an important family of antioxidant enzymes that modulate reactive oxygen species levels. It is largely unknown which SOD isoform(s) change in vivo in idiopathic pulmonary arterial hypertension (IPAH) patients.Methods: A total of 133 consecutive adult IPAH...
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Frontiers Media S.A.
2020-11-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2020.00509/full |
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| author | Rui Zhang Lan Wang Qin-Hua Zhao Rong Jiang Su-Gang Gong Xin Jiang Xi-Qi Xu Yang-Yang He Yuan Li Zhi-Cheng Jing Zhi-Cheng Jing |
| author_facet | Rui Zhang Lan Wang Qin-Hua Zhao Rong Jiang Su-Gang Gong Xin Jiang Xi-Qi Xu Yang-Yang He Yuan Li Zhi-Cheng Jing Zhi-Cheng Jing |
| author_sort | Rui Zhang |
| collection | DOAJ |
| description | Background: Superoxide dismutases (SODs) are an important family of antioxidant enzymes that modulate reactive oxygen species levels. It is largely unknown which SOD isoform(s) change in vivo in idiopathic pulmonary arterial hypertension (IPAH) patients.Methods: A total of 133 consecutive adult IPAH patients who underwent bone morphogenetic protein receptor type 2 (BMPR2) genetic counseling were enrolled in this prospective study. The plasma activities of three subtypes of SOD [copper–zinc (Cu/Zn-SOD), manganese (Mn-SOD), and extracellular SOD (Ec-SOD)] were examined.Results: The activities of SODs were significantly lower in IPAH patients than in healthy subjects. However, only Ec-SOD activity in BMPR2 mutation patients was significantly decreased compared to those in patients without a mutation. The reduced Ec-SOD activity was markedly associated with mean pulmonary arterial pressure, pulmonary vascular resistance (PVR), and 6-min walking distance (6MWD). The reduction of Mn-SOD activity was only associated with 6MWD. There was no association between Cu/Zn-SOD and hemodynamics. Patients with a lower Ec-SOD level had a worse survival compared to those with a higher baseline. The reduced Ec-SOD activity and the raised PVR increased the mortality risk.Conclusions: Ec-SOD was correlated with BMPR2 mutation, hemodynamic dysfunction, and poor outcomes. Circulating Ec-SOD could be a potentially vital antioxidant enzyme in the pathogenesis of IPAH. |
| first_indexed | 2024-12-12T09:05:12Z |
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| language | English |
| last_indexed | 2024-12-12T09:05:12Z |
| publishDate | 2020-11-01 |
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| series | Frontiers in Medicine |
| spelling | doaj.art-107a466071374f8c827c0f8534718dc42022-12-22T00:29:41ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2020-11-01710.3389/fmed.2020.00509560158Alteration of Extracellular Superoxide Dismutase in Idiopathic Pulmonary Arterial HypertensionRui Zhang0Lan Wang1Qin-Hua Zhao2Rong Jiang3Su-Gang Gong4Xin Jiang5Xi-Qi Xu6Yang-Yang He7Yuan Li8Zhi-Cheng Jing9Zhi-Cheng Jing10Department of Cardio-Pulmonary Circulation, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Cardio-Pulmonary Circulation, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Cardio-Pulmonary Circulation, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Cardio-Pulmonary Circulation, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Cardio-Pulmonary Circulation, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, ChinaDepartment of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, ChinaDepartment of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, ChinaDepartment of Cardio-Pulmonary Circulation, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Cardio-Pulmonary Circulation, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, ChinaBackground: Superoxide dismutases (SODs) are an important family of antioxidant enzymes that modulate reactive oxygen species levels. It is largely unknown which SOD isoform(s) change in vivo in idiopathic pulmonary arterial hypertension (IPAH) patients.Methods: A total of 133 consecutive adult IPAH patients who underwent bone morphogenetic protein receptor type 2 (BMPR2) genetic counseling were enrolled in this prospective study. The plasma activities of three subtypes of SOD [copper–zinc (Cu/Zn-SOD), manganese (Mn-SOD), and extracellular SOD (Ec-SOD)] were examined.Results: The activities of SODs were significantly lower in IPAH patients than in healthy subjects. However, only Ec-SOD activity in BMPR2 mutation patients was significantly decreased compared to those in patients without a mutation. The reduced Ec-SOD activity was markedly associated with mean pulmonary arterial pressure, pulmonary vascular resistance (PVR), and 6-min walking distance (6MWD). The reduction of Mn-SOD activity was only associated with 6MWD. There was no association between Cu/Zn-SOD and hemodynamics. Patients with a lower Ec-SOD level had a worse survival compared to those with a higher baseline. The reduced Ec-SOD activity and the raised PVR increased the mortality risk.Conclusions: Ec-SOD was correlated with BMPR2 mutation, hemodynamic dysfunction, and poor outcomes. Circulating Ec-SOD could be a potentially vital antioxidant enzyme in the pathogenesis of IPAH.https://www.frontiersin.org/articles/10.3389/fmed.2020.00509/fullidiopathic pulmonary arterial hypertensionsuperoxide dismutasesextracellular SODbiomarkersprognosis |
| spellingShingle | Rui Zhang Lan Wang Qin-Hua Zhao Rong Jiang Su-Gang Gong Xin Jiang Xi-Qi Xu Yang-Yang He Yuan Li Zhi-Cheng Jing Zhi-Cheng Jing Alteration of Extracellular Superoxide Dismutase in Idiopathic Pulmonary Arterial Hypertension Frontiers in Medicine idiopathic pulmonary arterial hypertension superoxide dismutases extracellular SOD biomarkers prognosis |
| title | Alteration of Extracellular Superoxide Dismutase in Idiopathic Pulmonary Arterial Hypertension |
| title_full | Alteration of Extracellular Superoxide Dismutase in Idiopathic Pulmonary Arterial Hypertension |
| title_fullStr | Alteration of Extracellular Superoxide Dismutase in Idiopathic Pulmonary Arterial Hypertension |
| title_full_unstemmed | Alteration of Extracellular Superoxide Dismutase in Idiopathic Pulmonary Arterial Hypertension |
| title_short | Alteration of Extracellular Superoxide Dismutase in Idiopathic Pulmonary Arterial Hypertension |
| title_sort | alteration of extracellular superoxide dismutase in idiopathic pulmonary arterial hypertension |
| topic | idiopathic pulmonary arterial hypertension superoxide dismutases extracellular SOD biomarkers prognosis |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2020.00509/full |
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