Decreased mitochondrial DNA copy number in nerve cells and the hippocampus during nicotine exposure is mediated by autophagy

Decreased mitochondrial DNA copy number in nerve cells and the hippocampus during nicotine exposure is mediated by autophagy

Cigarette smoke is a harmful air pollutant and nicotine dependence is the essential cause of the tobacco epidemic. Since mitochondrial abnormalities are associated with substance addiction, in this work we used mitochondrial DNA (mtDNA) copy number as an indicator of mitochondrial function to invest...

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Bibliographic Details
Main Authors: Hongjuan Wang, Huan Chen, Shulei Han, Yaning Fu, Yushan Tian, Yong Liu, An Wang, Hongwei Hou, Qingyuan Hu
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Ecotoxicology and Environmental Safety
Subjects:
nicotine
mtDNA copy number
autophagy
mitochondrial abnormalities
Online Access:http://www.sciencedirect.com/science/article/pii/S014765132100943X

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