Regenerative therapies as a potential treatment of erectile dysfunction
Erectile dysfunction (ED) is the most common sexual dysfunction disease in adult males. ED can be caused by many factors, such as vascular disease, neuropathy, metabolic disturbances, psychosocial causes, and side effects of medications. Although current oral phosphodiesterase type 5 inhibitors can...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Korean Urological Association
2023-07-01
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| Series: | Investigative and Clinical Urology |
| Subjects: | |
| Online Access: | https://www.icurology.org/pdf/10.4111/icu.20230104 |
| _version_ | 1797782597969903616 |
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| author | Doo Yong Chung Ji-Kan Ryu Guo Nan Yin |
| author_facet | Doo Yong Chung Ji-Kan Ryu Guo Nan Yin |
| author_sort | Doo Yong Chung |
| collection | DOAJ |
| description | Erectile dysfunction (ED) is the most common sexual dysfunction disease in adult males. ED can be caused by many factors, such as vascular disease, neuropathy, metabolic disturbances, psychosocial causes, and side effects of medications. Although current oral phosphodiesterase type 5 inhibitors can achieve a certain effect, they cause temporary dilatation of blood vessels with no curative treatment effects. Emerging targeted technologies, such as stem cell therapy, protein therapy, and low-intensity extracorporeal shock wave therapy (Li-ESWT), are being used to achieve more natural and long-lasting effects in treating ED. However, the development and application of these therapeutic methods are still in their infancy, and their pharmacological pathways and specific mechanisms have not been fully discovered. This article reviews the preclinical basic research progress of stem cells, proteins, and Li-ESWT therapy, as well as the current status of clinical application of Li-ESWT therapy. |
| first_indexed | 2024-03-13T00:13:12Z |
| format | Article |
| id | doaj.art-107d60323656446ca38ac1aac848f531 |
| institution | Directory Open Access Journal |
| issn | 2466-0493 2466-054X |
| language | English |
| last_indexed | 2024-03-13T00:13:12Z |
| publishDate | 2023-07-01 |
| publisher | Korean Urological Association |
| record_format | Article |
| series | Investigative and Clinical Urology |
| spelling | doaj.art-107d60323656446ca38ac1aac848f5312023-07-12T06:56:08ZengKorean Urological AssociationInvestigative and Clinical Urology2466-04932466-054X2023-07-0164431232410.4111/icu.20230104Regenerative therapies as a potential treatment of erectile dysfunctionDoo Yong Chung0https://orcid.org/0000-0001-8614-5742Ji-Kan Ryu1https://orcid.org/0000-0003-0025-6025Guo Nan Yin2https://orcid.org/0000-0002-2512-7337National Research Center for Sexual Medicine and Department of Urology, Inha University College of Medicine, Incheon, Korea.National Research Center for Sexual Medicine and Department of Urology, Inha University College of Medicine, Incheon, Korea.National Research Center for Sexual Medicine and Department of Urology, Inha University College of Medicine, Incheon, Korea.Erectile dysfunction (ED) is the most common sexual dysfunction disease in adult males. ED can be caused by many factors, such as vascular disease, neuropathy, metabolic disturbances, psychosocial causes, and side effects of medications. Although current oral phosphodiesterase type 5 inhibitors can achieve a certain effect, they cause temporary dilatation of blood vessels with no curative treatment effects. Emerging targeted technologies, such as stem cell therapy, protein therapy, and low-intensity extracorporeal shock wave therapy (Li-ESWT), are being used to achieve more natural and long-lasting effects in treating ED. However, the development and application of these therapeutic methods are still in their infancy, and their pharmacological pathways and specific mechanisms have not been fully discovered. This article reviews the preclinical basic research progress of stem cells, proteins, and Li-ESWT therapy, as well as the current status of clinical application of Li-ESWT therapy.https://www.icurology.org/pdf/10.4111/icu.20230104erectile dysfunctionextracorporeal shockwave therapiesproteinsregenerative medicinestem cell |
| spellingShingle | Doo Yong Chung Ji-Kan Ryu Guo Nan Yin Regenerative therapies as a potential treatment of erectile dysfunction Investigative and Clinical Urology erectile dysfunction extracorporeal shockwave therapies proteins regenerative medicine stem cell |
| title | Regenerative therapies as a potential treatment of erectile dysfunction |
| title_full | Regenerative therapies as a potential treatment of erectile dysfunction |
| title_fullStr | Regenerative therapies as a potential treatment of erectile dysfunction |
| title_full_unstemmed | Regenerative therapies as a potential treatment of erectile dysfunction |
| title_short | Regenerative therapies as a potential treatment of erectile dysfunction |
| title_sort | regenerative therapies as a potential treatment of erectile dysfunction |
| topic | erectile dysfunction extracorporeal shockwave therapies proteins regenerative medicine stem cell |
| url | https://www.icurology.org/pdf/10.4111/icu.20230104 |
| work_keys_str_mv | AT dooyongchung regenerativetherapiesasapotentialtreatmentoferectiledysfunction AT jikanryu regenerativetherapiesasapotentialtreatmentoferectiledysfunction AT guonanyin regenerativetherapiesasapotentialtreatmentoferectiledysfunction |