Global landscape of replicative DNA polymerase usage in the human genome
Profiling of human DNA polymerase Polε and Polα demonstrates their roles in leading and lagging strand DNA synthesis, and their independent measures allowed accurate predictions of replication dynamics and effects of transcription.
Main Authors: | , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2022-11-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-022-34929-8 |