Kidney and Urinary Tract Involvement in Chronic Myelomonocytic Leukemia
Chronic myelomonocytic leukemia (CMML) is a hematologic malignancy affecting the bone marrow and resulting in peripheral blood monocytosis. Kidney and urinary tract involvement is common and can present dramatically with life-threatening consequences. Kidney involvement can be the result of direct o...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-02-01
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| Series: | Kidney Medicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590059523001875 |
| _version_ | 1797345896965341184 |
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| author | Rose Mary Attieh Farhana Begum David Chitty Hassan Izzedine Kenar D. Jhaveri |
| author_facet | Rose Mary Attieh Farhana Begum David Chitty Hassan Izzedine Kenar D. Jhaveri |
| author_sort | Rose Mary Attieh |
| collection | DOAJ |
| description | Chronic myelomonocytic leukemia (CMML) is a hematologic malignancy affecting the bone marrow and resulting in peripheral blood monocytosis. Kidney and urinary tract involvement is common and can present dramatically with life-threatening consequences. Kidney involvement can be the result of direct or indirect mechanisms, including prerenal azotemia, glomerular disease, tubulointerstitial involvement, and renovascular disorders. Urinary tract involvement, electrolyte and acid-base disorders, as well as nephrotoxicity from treatment of the disorder can also occur. Given this multifactorial pathogenesis involving several mechanisms concomitantly, nephrologists must exercise heightened awareness and maintain a low threshold for kidney biopsy. There is a pressing need for future research endeavors to elucidate and target the manifestations of CMML that involve the kidneys with the ultimate goal of augmenting overall prognosis and therapeutic outcomes. |
| first_indexed | 2024-03-08T11:25:28Z |
| format | Article |
| id | doaj.art-107de851c52e4864adb4c21420fd0b8a |
| institution | Directory Open Access Journal |
| issn | 2590-0595 |
| language | English |
| last_indexed | 2024-03-08T11:25:28Z |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Kidney Medicine |
| spelling | doaj.art-107de851c52e4864adb4c21420fd0b8a2024-01-26T05:34:30ZengElsevierKidney Medicine2590-05952024-02-0162100769Kidney and Urinary Tract Involvement in Chronic Myelomonocytic LeukemiaRose Mary Attieh0Farhana Begum1David Chitty2Hassan Izzedine3Kenar D. Jhaveri4Division of Kidney Diseases and Hypertension, Department of Medicine, Glomerular Center at Northwell Health, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Great Neck, New YorkDepartment of Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Manhasset, New YorkNorthwell Health Cancer Institute, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Feinstein Institute for Medical Research, Lake Success, New YorkDepartment of Nephrology, Peupliers Private Hospital, Ramsay Générale de Santé, Paris, FranceDivision of Kidney Diseases and Hypertension, Department of Medicine, Glomerular Center at Northwell Health, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Great Neck, New York; Address for Correspondence: Kenar D. Jhaveri, MD, Division of Kidney Diseases and Hypertension, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Great Neck, New York.Chronic myelomonocytic leukemia (CMML) is a hematologic malignancy affecting the bone marrow and resulting in peripheral blood monocytosis. Kidney and urinary tract involvement is common and can present dramatically with life-threatening consequences. Kidney involvement can be the result of direct or indirect mechanisms, including prerenal azotemia, glomerular disease, tubulointerstitial involvement, and renovascular disorders. Urinary tract involvement, electrolyte and acid-base disorders, as well as nephrotoxicity from treatment of the disorder can also occur. Given this multifactorial pathogenesis involving several mechanisms concomitantly, nephrologists must exercise heightened awareness and maintain a low threshold for kidney biopsy. There is a pressing need for future research endeavors to elucidate and target the manifestations of CMML that involve the kidneys with the ultimate goal of augmenting overall prognosis and therapeutic outcomes.http://www.sciencedirect.com/science/article/pii/S2590059523001875Chronic myelomonocytic leukemiaglomerulopathykidney injurylysozyme-induced nephropathyonconephrologytumor lysis syndrome |
| spellingShingle | Rose Mary Attieh Farhana Begum David Chitty Hassan Izzedine Kenar D. Jhaveri Kidney and Urinary Tract Involvement in Chronic Myelomonocytic Leukemia Kidney Medicine Chronic myelomonocytic leukemia glomerulopathy kidney injury lysozyme-induced nephropathy onconephrology tumor lysis syndrome |
| title | Kidney and Urinary Tract Involvement in Chronic Myelomonocytic Leukemia |
| title_full | Kidney and Urinary Tract Involvement in Chronic Myelomonocytic Leukemia |
| title_fullStr | Kidney and Urinary Tract Involvement in Chronic Myelomonocytic Leukemia |
| title_full_unstemmed | Kidney and Urinary Tract Involvement in Chronic Myelomonocytic Leukemia |
| title_short | Kidney and Urinary Tract Involvement in Chronic Myelomonocytic Leukemia |
| title_sort | kidney and urinary tract involvement in chronic myelomonocytic leukemia |
| topic | Chronic myelomonocytic leukemia glomerulopathy kidney injury lysozyme-induced nephropathy onconephrology tumor lysis syndrome |
| url | http://www.sciencedirect.com/science/article/pii/S2590059523001875 |
| work_keys_str_mv | AT rosemaryattieh kidneyandurinarytractinvolvementinchronicmyelomonocyticleukemia AT farhanabegum kidneyandurinarytractinvolvementinchronicmyelomonocyticleukemia AT davidchitty kidneyandurinarytractinvolvementinchronicmyelomonocyticleukemia AT hassanizzedine kidneyandurinarytractinvolvementinchronicmyelomonocyticleukemia AT kenardjhaveri kidneyandurinarytractinvolvementinchronicmyelomonocyticleukemia |