A novel translabial platform utilizing bioexcipients from Litchi chinesis for the delivery of rosiglitazone maleate
The aim of this study was to formulate drug-loaded bio-lipstrips using novel bioexcipients isolated from the fruit pulp of Litchi chinesis (biomaterial L) and to explore the potentiality of lip skin as a novel translabial drug delivery system. The biomaterial, prepared by a simplified economical pro...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2013-12-01
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| Series: | Acta Pharmaceutica Sinica B |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211383513000956 |
| _version_ | 1818542378678484992 |
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| author | N.V. Satheesh Madhav Abhay Pratap Yadav |
| author_facet | N.V. Satheesh Madhav Abhay Pratap Yadav |
| author_sort | N.V. Satheesh Madhav |
| collection | DOAJ |
| description | The aim of this study was to formulate drug-loaded bio-lipstrips using novel bioexcipients isolated from the fruit pulp of Litchi chinesis (biomaterial L) and to explore the potentiality of lip skin as a novel translabial drug delivery system. The biomaterial, prepared by a simplified economical process and purified by hot dialysis, was subjected to various physicochemical evaluations along with spectral analysis including UV, FT-IR, Mass and 1H NMR. The lipstrip formulated with the novel bioexcipients was screened for its functional properties, including filmability using a film-casting method, and bio/muco-adhesitivity using a shear-stress method, the Park and Robinson method and a rotating cylinder method. Rosiglitazone-loaded bio-lipstrips were formulated by using biomaterial L as a strip former and dextrose as a flexicizer. The formulated strips were subjected to various evaluations, including thickness, folding endurance, in-vitro release and in-vivo release. The release of rosiglitazone maleate was maintained over 24 h, which was confirmed in in-vitro and in-vivo release experiments. Our results reveal that this biopolymer possesses promising stripability as well as bio-adhesitivity. The formulated bio-lipstrips are feasible for delivering rosiglitazone maleate by translabial administration. |
| first_indexed | 2024-12-11T22:21:17Z |
| format | Article |
| id | doaj.art-107e121f6faf4a858e9e739b51269ec7 |
| institution | Directory Open Access Journal |
| issn | 2211-3835 2211-3843 |
| language | English |
| last_indexed | 2024-12-11T22:21:17Z |
| publishDate | 2013-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Acta Pharmaceutica Sinica B |
| spelling | doaj.art-107e121f6faf4a858e9e739b51269ec72022-12-22T00:48:25ZengElsevierActa Pharmaceutica Sinica B2211-38352211-38432013-12-013640841510.1016/j.apsb.2013.10.004A novel translabial platform utilizing bioexcipients from Litchi chinesis for the delivery of rosiglitazone maleateN.V. Satheesh MadhavAbhay Pratap YadavThe aim of this study was to formulate drug-loaded bio-lipstrips using novel bioexcipients isolated from the fruit pulp of Litchi chinesis (biomaterial L) and to explore the potentiality of lip skin as a novel translabial drug delivery system. The biomaterial, prepared by a simplified economical process and purified by hot dialysis, was subjected to various physicochemical evaluations along with spectral analysis including UV, FT-IR, Mass and 1H NMR. The lipstrip formulated with the novel bioexcipients was screened for its functional properties, including filmability using a film-casting method, and bio/muco-adhesitivity using a shear-stress method, the Park and Robinson method and a rotating cylinder method. Rosiglitazone-loaded bio-lipstrips were formulated by using biomaterial L as a strip former and dextrose as a flexicizer. The formulated strips were subjected to various evaluations, including thickness, folding endurance, in-vitro release and in-vivo release. The release of rosiglitazone maleate was maintained over 24 h, which was confirmed in in-vitro and in-vivo release experiments. Our results reveal that this biopolymer possesses promising stripability as well as bio-adhesitivity. The formulated bio-lipstrips are feasible for delivering rosiglitazone maleate by translabial administration.http://www.sciencedirect.com/science/article/pii/S2211383513000956TranslabialRosiglitazoneLitchi chinesisStripBio-polymer |
| spellingShingle | N.V. Satheesh Madhav Abhay Pratap Yadav A novel translabial platform utilizing bioexcipients from Litchi chinesis for the delivery of rosiglitazone maleate Acta Pharmaceutica Sinica B Translabial Rosiglitazone Litchi chinesis Strip Bio-polymer |
| title | A novel translabial platform utilizing bioexcipients from Litchi chinesis for the delivery of rosiglitazone maleate |
| title_full | A novel translabial platform utilizing bioexcipients from Litchi chinesis for the delivery of rosiglitazone maleate |
| title_fullStr | A novel translabial platform utilizing bioexcipients from Litchi chinesis for the delivery of rosiglitazone maleate |
| title_full_unstemmed | A novel translabial platform utilizing bioexcipients from Litchi chinesis for the delivery of rosiglitazone maleate |
| title_short | A novel translabial platform utilizing bioexcipients from Litchi chinesis for the delivery of rosiglitazone maleate |
| title_sort | novel translabial platform utilizing bioexcipients from litchi chinesis for the delivery of rosiglitazone maleate |
| topic | Translabial Rosiglitazone Litchi chinesis Strip Bio-polymer |
| url | http://www.sciencedirect.com/science/article/pii/S2211383513000956 |
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