Efficacy and Safety of Human Serum Albumin–Cisplatin Complex in U87MG Xenograft Mouse Models

Efficacy and Safety of Human Serum Albumin–Cisplatin Complex in U87MG Xenograft Mouse Models

Cisplatin (cis-diamminedichloroplatinum (II), CDDP) is a chemotherapeutic drug widely used against many solid tumors. A pharmacokinetics study found that CDDP can bind to human serum albumin (HSA), which is the most abundant plasma protein in serum. HSA has the advantage of being a nanocarrier and c...

Full description

Bibliographic Details
Main Authors:	Cho Rong Park, Hyo Young Kim, Myung Geun Song, Yun-Sang Lee, Hyewon Youn, June-Key Chung, Gi Jeong Cheon, Keon Wook Kang
Format:	Article
Language:	English
Published:	MDPI AG 2020-10-01
Series:	International Journal of Molecular Sciences
Subjects:	cisplatin (CDDP) human serum albumin (HSA) cancer therapeutics drug delivery
Online Access:	https://www.mdpi.com/1422-0067/21/21/7932

Similar Items

PEGylated Human Serum Albumin: Review of PEGylation, Purification and Characterization Methods
by: Parvin Akbarzadehlaleh, et al.
Published: (2016-09-01)

Evaluation of the effects of cisplatin and the cisplatin-alum mixture as adjuvants for increasing the efficacy of vaccination against Salmonella typhimurium in Balb/c mice
by: Ebrahim Mazloomi, et al.
Published: (2021-11-01)

The Effects of Silver Nanoparticles Coatings in Effective Drug Delivery: Human Serum Albumin Interaction
by: Azadeh Hekmat, et al.
Published: (2020-06-01)

AlbuCORE: an albumin-based molecular scaffold for multivalent biologics design
by: Mario Sanches, et al.
Published: (2020-01-01)

Anthocyanins Isolated from <i>Vitis coignetiae Pulliat</i> Enhances Cisplatin Sensitivity in MCF-7 Human Breast Cancer Cells through Inhibition of Akt and NF-κB Activation
by: Anjugam Paramanantham, et al.
Published: (2020-08-01)

Impact of Halogen Substituents on Interactions between 2-Phenyl-2,3-dihydroqulinazolin-4(1H)-one Derivatives and Human Serum Albumin
by: Shangzhong Liu, et al.
Published: (2012-02-01)

The microneedles carrying cisplatin and IR820 to perform synergistic chemo-photodynamic therapy against breast cancer
by: Ji-jun Fu, et al.
Published: (2020-10-01)

Synthesis and In Vitro Assessment of pH-Sensitive Human Serum Albumin Conjugates of Pirarubicin
by: Kenji Tsukigawa, et al.
Published: (2020-12-01)

Imaging of Indocyanine Green-Human Serum Albumin (ICG-HSA) Complex in Secreted Protein Acidic and Rich in Cysteine (SPARC)-Expressing Glioblastoma
by: Hye Jung Jang, et al.
Published: (2023-01-01)

Exploring the Interactions Between Caffeic Acid and Human Serum Albumin Using Spectroscopic and Molecular Docking Techniques
by: Ali Jahanban-Esfahlan, et al.
Published: (2021-02-01)

The investigation of interaction between Thioguanine and human serum albumin by fluorescence and modeling
by: Xin An, et al.
Published: (2017-05-01)

Advances in decompensated cirrhosis treatment by human serum albumin
by: ZHANG Chenxi, et al.
Published: (2023-01-01)

Kinetic Analyses of Data from a Human Serum Albumin Assay Using the liSPR System
by: Anja Henseleit, et al.
Published: (2015-01-01)

The significance of MGMT protein detection in evaluation of osteosarcoma necrosis rate after cisplatin chemotherapy
by: Qiu Cui, et al.
Published: (2011-05-01)

Tumor Cell Capture Using Platelet-Based and Platelet-Mimicking Modified Human Serum Albumin Submicron Particles
by: Xiaotong Zhao, et al.
Published: (2022-11-01)

The Chinese medicine JC-001 enhances the chemosensitivity of Lewis lung tumors to cisplatin by modulating the immune response
by: Meng-Hsien Chuang, et al.
Published: (2017-04-01)

Fabrication and Characterization of Human Serum Albumin Particles Loaded with Non-Sericin Extract Obtained from Silk Cocoon as a Carrier System for Hydrophobic Substances
by: Kanyaluck Jantakee, et al.
Published: (2021-01-01)

Binding Studies of AICAR and Human Serum Albumin by Spectroscopic, Theoretical, and Computational Methodologies
by: Shokoufeh Hashempour, et al.
Published: (2020-11-01)

The Effect of Length and Structure of Attached Polyethylene Glycol Chain on Hydrodynamic Radius, and Separation of PEGylated Human Serum Albumin by Chromatography
by: Parvin Akbarzadehlaleh, et al.
Published: (2021-09-01)

Evaluation of the interactions between human serum albumin (HSA) and warfarin or diflunisal by using molecular fluorescence using two approaches
by: Susana Amézqueta, et al.
Published: (2018-03-01)

Albumin-Based Nanocarriers for the Simultaneous Delivery of Antioxidant Gene and Phytochemical to Combat Oxidative Stress
by: Saba Naqvi, et al.
Published: (2022-08-01)

Prospective Evaluation of a Circulating Tumor Cell Sensitivity Profile to Predict Response to Cisplatin Chemotherapy in Metastatic Breast Cancer Patients
by: I. E. de Kruijff, et al.
Published: (2021-06-01)

Albumin Binds Doxorubicin via Self–Assembling Dyes as Specific Polymolecular Ligands
by: Anna Jagusiak, et al.
Published: (2022-05-01)

Glycation and secondary conformational changes of human serum albumin: study of the FTIR spectroscopic curve-fitting technique
by: Yu-Ting Huang, et al.
Published: (2016-05-01)

Testing for Ketoprofen Binding to HSA Coated Magnetic Nanoparticles under Normal Conditions and after Oxidative Stress
by: Marta Ziegler-Borowska, et al.
Published: (2020-04-01)

Study of the Interactions of Bovine Serum Albumin with the New Anti-Inflammatory Agent 4-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-N′-[(4-ethoxy-phenyl)methylidene]benzohydrazide Using a Multi-Spectroscopic Approach and Molecular Docking
by: Tanveer A. Wani, et al.
Published: (2017-07-01)

Sensitization of MCF7 Cells with High Notch1 Activity by Cisplatin and Histone Deacetylase Inhibitors Applied Together
by: Anna Wawruszak, et al.
Published: (2021-05-01)

Lung‐specific exosomes for co‐delivery of CD47 blockade and cisplatin for the treatment of non–small cell lung cancer
by: Zhilei Cui, et al.
Published: (2022-10-01)

Interactions Between Albumin and Fatty Acids Studied by NMR Spectroscopy
by: GAO Dong-li, et al.
Published: (2018-09-01)

Cisplatin-loaded gold nanoshells mediate chemo-photothermal therapy against primary and distal lung cancers growth
by: Shu-Jyuan Yang, et al.
Published: (2023-02-01)

MFAP2 enhances cisplatin resistance in gastric cancer cells by regulating autophagy
by: Meng Li, et al.
Published: (2023-06-01)

Dissecting the Interactions between Chlorin e6 and Human Serum Albumin
by: Alessia Marconi, et al.
Published: (2023-03-01)

Lipoic Acid Restores Binding of Zinc Ions to Human Serum Albumin
by: Samah Al-Harthi, et al.
Published: (2022-07-01)

4-Chloro-1,2-phenylenediamine induced structural perturbation and genotoxic aggregation in human serum albumin
by: Mohd Sharib Warsi, et al.
Published: (2022-09-01)

Protective effect of cactus cladode extract against cisplatin induced oxidative stress, genotoxicity and apoptosis in balb/c mice: combination with phytochemical composition
by: Brahmi Dalel, et al.
Published: (2012-07-01)

Macromolecular sizes of serum albumins in its aqueous solutions
by: Oleksii V. Khorolskyi, et al.
Published: (2020-12-01)

ML216-Induced BLM Helicase Inhibition Sensitizes PCa Cells to the DNA-Crosslinking Agent Cisplatin
by: Xiao-Yan Ma, et al.
Published: (2022-12-01)

Conformation and Aggregation of Human Serum Albumin in the Presence of Green Tea Polyphenol (EGCg) and/or Palmitic Acid
by: Xiaowei Sun, et al.
Published: (2019-11-01)

RasGAP-derived peptide GAP159 enhances cisplatin-induced cytotoxicity and apoptosis in HCT116 cells
by: Hao Zhang, et al.
Published: (2014-04-01)

Cetuximab-Modified Human Serum Albumin Nanoparticles Co-Loaded with Doxorubicin and MDR1 siRNA for the Treatment of Drug-Resistant Breast Tumors
by: Yang X, et al.
Published: (2021-10-01)