HNO Protects the Myocardium against Reperfusion Injury, Inhibiting the mPTP Opening via PKCε Activation

HNO Protects the Myocardium against Reperfusion Injury, Inhibiting the mPTP Opening via PKCε Activation

Donors of nitroxyl (HNO), the one electron-reduction product of nitric oxide (NO<sup>.</sup>), positively modulate cardiac contractility/relaxation while limiting ischemia-reperfusion (I/R) injury. The mechanisms underpinning HNO anti-ischemic effects remain poorly understood. Using isol...

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Bibliographic Details
Main Authors:	Daniele Mancardi, Pasquale Pagliaro, Lisa A. Ridnour, Carlo G. Tocchetti, Katrina Miranda, Magdalena Juhaszova, Steven J. Sollott, David A. Wink, Nazareno Paolocci
Format:	Article
Language:	English
Published:	MDPI AG 2022-02-01
Series:	Antioxidants
Subjects:	myocardial reperfusion injury nitroxyl (HNO) nitric oxide (NO<sup>.</sup>) PKCε mitochondrial permeability transition pore (mPTP) K<sub>ATP</sub> channels
Online Access:	https://www.mdpi.com/2076-3921/11/2/382

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