A non-nucleotide agonist that binds covalently to cysteine residues of STING

A non-nucleotide agonist that binds covalently to cysteine residues of STING

Stimulator of interferon genes (STING) is an ER-localized transmembrane protein and the receptor for 2',3'-cyclic guanosine monophosphate–adenosine monophosphate (cGAMP), which is a second messenger produced by cGAMP synthase (cGAS), a cytosolic double-stranded DNA sensor. The cGAS...

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Bibliographic Details
Main Authors: Kentaro Matsumoto, Shenwei Ni, Hiroyuki Arai, Takashi Toyama, Yoshiro Saito, Takehiro Suzuki, Naoshi Dohmae, Kojiro Mukai, Tomohiko Taguchi
Format: Article
Language:English
Published: Japan Society for Cell Biology 2022-12-01
Series:Cell Structure and Function
Subjects:
sting agonist
cysteine modification
innate immunity
phenylarsine oxide
Online Access:https://www.jstage.jst.go.jp/article/csf/48/1/48_22085/_html/-char/en

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