Neutrophil Extracellular Traps and Pancreatic Cancer Development: A Vicious Cycle
Neutrophil extracellular traps (NETs) are a neutrophil-generated extracellular network of chromatin and chromatin-bound molecules with antimicrobial potency. Recent data suggest that NETs are associated with cancer progression and cancer-associated hypercoagulability. Pancreatic adenocarcinoma (PDAC...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/14/3339 |
| _version_ | 1797433713614651392 |
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| author | Michail Mitsis Panagiota Drosou Vasileios Tatsis Georgios S. Markopoulos |
| author_facet | Michail Mitsis Panagiota Drosou Vasileios Tatsis Georgios S. Markopoulos |
| author_sort | Michail Mitsis |
| collection | DOAJ |
| description | Neutrophil extracellular traps (NETs) are a neutrophil-generated extracellular network of chromatin and chromatin-bound molecules with antimicrobial potency. Recent data suggest that NETs are associated with cancer progression and cancer-associated hypercoagulability. Pancreatic adenocarcinoma (PDAC) is a lethal type of cancer in which hypercoagulability and cancer-related thrombosis are among the main complications. In the current report, we summarize the available data on the interplay between NET formation and PDAC development. We conclude that NETs support a dual role during PDAC progression and metastasis. Their formation is on the one hand an important event that shapes the cancer microenvironment to support cancer cell proliferation, invasion and metastasis. On the other hand, NETs may lead to cancer-associated thrombosis. Both mechanisms seem to be dependent on distinct molecular mechanisms that link inflammation to cancer progression. Collectively, NET formation may contribute to the pathogenesis of PDAC, while during cancer development, the proinflammatory environment enables the induction of new NETs and thrombi, forming a vicious cycle. We suggest that targeting NET formation may be an effective mechanism to inhibit both PDAC development and the accompanying hypercoagulability. |
| first_indexed | 2024-03-09T10:20:56Z |
| format | Article |
| id | doaj.art-1081fe7277524414b06738a555929dc4 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T10:20:56Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-1081fe7277524414b06738a555929dc42023-12-01T21:59:08ZengMDPI AGCancers2072-66942022-07-011414333910.3390/cancers14143339Neutrophil Extracellular Traps and Pancreatic Cancer Development: A Vicious CycleMichail Mitsis0Panagiota Drosou1Vasileios Tatsis2Georgios S. Markopoulos3Department of Surgery, School of Health Sciences, Faculty of Medicine, University Hospital of Ioannina, University of Ioannina, 455 00 Ioannina, GreeceDepartment of Surgery, School of Health Sciences, Faculty of Medicine, University Hospital of Ioannina, University of Ioannina, 455 00 Ioannina, GreeceDepartment of Surgery, School of Health Sciences, Faculty of Medicine, University Hospital of Ioannina, University of Ioannina, 455 00 Ioannina, GreeceDepartment of Surgery, School of Health Sciences, Faculty of Medicine, University Hospital of Ioannina, University of Ioannina, 455 00 Ioannina, GreeceNeutrophil extracellular traps (NETs) are a neutrophil-generated extracellular network of chromatin and chromatin-bound molecules with antimicrobial potency. Recent data suggest that NETs are associated with cancer progression and cancer-associated hypercoagulability. Pancreatic adenocarcinoma (PDAC) is a lethal type of cancer in which hypercoagulability and cancer-related thrombosis are among the main complications. In the current report, we summarize the available data on the interplay between NET formation and PDAC development. We conclude that NETs support a dual role during PDAC progression and metastasis. Their formation is on the one hand an important event that shapes the cancer microenvironment to support cancer cell proliferation, invasion and metastasis. On the other hand, NETs may lead to cancer-associated thrombosis. Both mechanisms seem to be dependent on distinct molecular mechanisms that link inflammation to cancer progression. Collectively, NET formation may contribute to the pathogenesis of PDAC, while during cancer development, the proinflammatory environment enables the induction of new NETs and thrombi, forming a vicious cycle. We suggest that targeting NET formation may be an effective mechanism to inhibit both PDAC development and the accompanying hypercoagulability.https://www.mdpi.com/2072-6694/14/14/3339NETsNETosishypercoagulabilitypancreatic adenocarcinomainflammationcancer |
| spellingShingle | Michail Mitsis Panagiota Drosou Vasileios Tatsis Georgios S. Markopoulos Neutrophil Extracellular Traps and Pancreatic Cancer Development: A Vicious Cycle Cancers NETs NETosis hypercoagulability pancreatic adenocarcinoma inflammation cancer |
| title | Neutrophil Extracellular Traps and Pancreatic Cancer Development: A Vicious Cycle |
| title_full | Neutrophil Extracellular Traps and Pancreatic Cancer Development: A Vicious Cycle |
| title_fullStr | Neutrophil Extracellular Traps and Pancreatic Cancer Development: A Vicious Cycle |
| title_full_unstemmed | Neutrophil Extracellular Traps and Pancreatic Cancer Development: A Vicious Cycle |
| title_short | Neutrophil Extracellular Traps and Pancreatic Cancer Development: A Vicious Cycle |
| title_sort | neutrophil extracellular traps and pancreatic cancer development a vicious cycle |
| topic | NETs NETosis hypercoagulability pancreatic adenocarcinoma inflammation cancer |
| url | https://www.mdpi.com/2072-6694/14/14/3339 |
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