Family history of cancer and risk for esophageal and gastric cancer in Shanxi, China
<p>Abstract</p> <p>Background</p> <p>Family history (FH) by different relative types and risk of upper gastrointestinal (UGI) cancers has been only rarely reported; the data on UGI cancer survival are sparse.</p> <p>Methods</p> <p>600 esophageal...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2009-08-01
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| Series: | BMC Cancer |
| Online Access: | http://www.biomedcentral.com/1471-2407/9/269 |
| _version_ | 1818387301083906048 |
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| author | Goldstein Alisa Ding Ti Giffen Carol Han XiaoYou Hu Nan Gao Ying Taylor Philip |
| author_facet | Goldstein Alisa Ding Ti Giffen Carol Han XiaoYou Hu Nan Gao Ying Taylor Philip |
| author_sort | Goldstein Alisa |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Family history (FH) by different relative types and risk of upper gastrointestinal (UGI) cancers has been only rarely reported; the data on UGI cancer survival are sparse.</p> <p>Methods</p> <p>600 esophageal squamous cell carcinoma (ESCC) cases, 598 gastric cardia adenocarcinoma cases, and 316 gastric non-cardia adenocarcinoma cases, and 1514 age-, gender-, and neighborhood-matched controls were asked for FH in first degree relatives and non-blood relatives. Odds ratios (ORs) and 95% confidence intervals (CIs) from logistic regressions, and hazard ratios (HRs) from Cox proportional hazard regressions were estimated.</p> <p>Results</p> <p>Increased ESCC risk was associated with FH of any cancer (OR = 1.72, 95% CI = 1.39–2.12), FH of any UGI cancer (OR = 2.28, 95%CI = 1.77–2.95) and FH of esophageal cancer (OR = 2.84, 95%CI = 2.09–3.86), but not FH of non-UGI cancer. Individuals with two or more affected first-degree relatives had 10-fold increased ESCC risk. FH of gastric cardia cancer was associated with an increased risk of all three cancers. Cancer in non-blood relatives was not associated with risk of any UGI cancer. FH of UGI cancer was associated with a poorer survival rate among younger ESCC cases (HR = 1.82, 95%CI = 1.01–3.29).</p> <p>Conclusion</p> <p>These data provide strong evidence that shared susceptibility is involved in esophageal carcinogenesis and also suggest a role in prognosis.</p> |
| first_indexed | 2024-12-14T04:07:46Z |
| format | Article |
| id | doaj.art-108213d1a7ec4723bd8e893f99d7bc0b |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-14T04:07:46Z |
| publishDate | 2009-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-108213d1a7ec4723bd8e893f99d7bc0b2022-12-21T23:17:47ZengBMCBMC Cancer1471-24072009-08-019126910.1186/1471-2407-9-269Family history of cancer and risk for esophageal and gastric cancer in Shanxi, ChinaGoldstein AlisaDing TiGiffen CarolHan XiaoYouHu NanGao YingTaylor Philip<p>Abstract</p> <p>Background</p> <p>Family history (FH) by different relative types and risk of upper gastrointestinal (UGI) cancers has been only rarely reported; the data on UGI cancer survival are sparse.</p> <p>Methods</p> <p>600 esophageal squamous cell carcinoma (ESCC) cases, 598 gastric cardia adenocarcinoma cases, and 316 gastric non-cardia adenocarcinoma cases, and 1514 age-, gender-, and neighborhood-matched controls were asked for FH in first degree relatives and non-blood relatives. Odds ratios (ORs) and 95% confidence intervals (CIs) from logistic regressions, and hazard ratios (HRs) from Cox proportional hazard regressions were estimated.</p> <p>Results</p> <p>Increased ESCC risk was associated with FH of any cancer (OR = 1.72, 95% CI = 1.39–2.12), FH of any UGI cancer (OR = 2.28, 95%CI = 1.77–2.95) and FH of esophageal cancer (OR = 2.84, 95%CI = 2.09–3.86), but not FH of non-UGI cancer. Individuals with two or more affected first-degree relatives had 10-fold increased ESCC risk. FH of gastric cardia cancer was associated with an increased risk of all three cancers. Cancer in non-blood relatives was not associated with risk of any UGI cancer. FH of UGI cancer was associated with a poorer survival rate among younger ESCC cases (HR = 1.82, 95%CI = 1.01–3.29).</p> <p>Conclusion</p> <p>These data provide strong evidence that shared susceptibility is involved in esophageal carcinogenesis and also suggest a role in prognosis.</p>http://www.biomedcentral.com/1471-2407/9/269 |
| spellingShingle | Goldstein Alisa Ding Ti Giffen Carol Han XiaoYou Hu Nan Gao Ying Taylor Philip Family history of cancer and risk for esophageal and gastric cancer in Shanxi, China BMC Cancer |
| title | Family history of cancer and risk for esophageal and gastric cancer in Shanxi, China |
| title_full | Family history of cancer and risk for esophageal and gastric cancer in Shanxi, China |
| title_fullStr | Family history of cancer and risk for esophageal and gastric cancer in Shanxi, China |
| title_full_unstemmed | Family history of cancer and risk for esophageal and gastric cancer in Shanxi, China |
| title_short | Family history of cancer and risk for esophageal and gastric cancer in Shanxi, China |
| title_sort | family history of cancer and risk for esophageal and gastric cancer in shanxi china |
| url | http://www.biomedcentral.com/1471-2407/9/269 |
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