Wnt-5a induces the conversion of silent to functional synapses in the hippocampus

Wnt-5a induces the conversion of silent to functional synapses in the hippocampus

Synapse unsilencing is an essential mechanism for experience-dependent plasticity. Here, we showed that the application of the ligand Wnt-5a converts glutamatergic silent synapses into functional ones by increasing both α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) and N-methyl-D-aspa...

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Bibliographic Details
Main Authors: Carla Álvarez-Ferradas, Mario Wellmann, Koyam Morales, Marco Fuenzalida, Waldo Cerpa, Nibaldo C. Inestrosa, Christian Bonansco
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Wnt signaling
silent synapses
hippocampus
development
NMDA postsynaptic currents
AMPA receptors
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2022.1024034/full

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https://www.frontiersin.org/articles/10.3389/fnmol.2022.1024034/full

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