Widespread genomic/molecular alterations of DNA helicases and their clinical/therapeutic implications across human cancer

Widespread genomic/molecular alterations of DNA helicases and their clinical/therapeutic implications across human cancer

DNA helicases are essential to genomic stability by regulating DNA metabolisms and their loss-of-function mutations lead to genomic instability and predisposition to cancer. Paradoxically, overexpression of DNA helicases is observed in several cancers. Here we analyzed genomic and molecular alterati...

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Bibliographic Details
Main Authors: Xin Qin, Jing Wang, Xing Wang, Tao Huang, Zhiqing Fang, Lei Yan, Yidong Fan, Dawei Xu
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Alt-EJ
DNA helicase
Genomic instability
Predictive biomarker
Telomere
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332222015827

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