Study of Teratogenic and Cytotoxic Effects of BDP18 Tri-Block Copolymer (PLA-PEG2000-PLA) on Chicken Embryos
Background & Objectives: Polymers as drug carriers are recent advances in drug delivery and led to the new advent field that called polymer treatment. In the present study, the toxic and teratogenic effects of BDP18 were evaluated against chicken embryos as a model. Methods: The BDP18 tri-bloc...
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| Format: | Article |
| Language: | fas |
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Ardabil University of Medical Sciences
2013-04-01
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| Series: | Journal of Ardabil University of Medical Sciences |
| Subjects: | |
| Online Access: | http://jarums.arums.ac.ir/browse.php?a_code=A-10-27-98&slc_lang=en&sid=1 |
| _version_ | 1818248943780233216 |
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| author | Asadollah Asadi Arash Abdolmaleki Farhood Najafi |
| author_facet | Asadollah Asadi Arash Abdolmaleki Farhood Najafi |
| author_sort | Asadollah Asadi |
| collection | DOAJ |
| description | Background & Objectives: Polymers as drug carriers are recent advances in drug delivery and led to the new advent field that called polymer treatment. In the present study, the toxic and teratogenic effects of BDP18 were evaluated against chicken embryos as a model. Methods: The BDP18 tri-block copolymer (PLA-PEG2000-PLA) was synthesized. The compound solution was injected in triplicate examination, in the air sac of the eggs, at third day of incubation, and survived fraction of the embryos and Morphological and skeletal changes were recorded . Results: The survived fraction of the embryos depends on the compound concentration. In concentration of 20 mg/ml , 33.3% of the embryos were survived and the LD50 was 10.87 mg/egg . Morphological study of the treated embryos showed no abnormalities in embryos , and skeletal staining showed the deletion of caudal vertebrate in high concentration. Conclusion: The BDP18 copolymer had low toxic and teratogenic effects against the embryos, but it caused the deletion of caudal vertebrate at concentrations above the threshold (10 mg/ml). This polymer can be used as an effective drug -release system in low concentrations . |
| first_indexed | 2024-12-12T15:28:38Z |
| format | Article |
| id | doaj.art-1082e79ad93043a59a71062eddca9b2d |
| institution | Directory Open Access Journal |
| issn | 2228-7280 2228-7299 |
| language | fas |
| last_indexed | 2024-12-12T15:28:38Z |
| publishDate | 2013-04-01 |
| publisher | Ardabil University of Medical Sciences |
| record_format | Article |
| series | Journal of Ardabil University of Medical Sciences |
| spelling | doaj.art-1082e79ad93043a59a71062eddca9b2d2022-12-22T00:20:10ZfasArdabil University of Medical SciencesJournal of Ardabil University of Medical Sciences2228-72802228-72992013-04-011311623Study of Teratogenic and Cytotoxic Effects of BDP18 Tri-Block Copolymer (PLA-PEG2000-PLA) on Chicken EmbryosAsadollah Asadi0Arash Abdolmaleki1Farhood Najafi2 Background & Objectives: Polymers as drug carriers are recent advances in drug delivery and led to the new advent field that called polymer treatment. In the present study, the toxic and teratogenic effects of BDP18 were evaluated against chicken embryos as a model. Methods: The BDP18 tri-block copolymer (PLA-PEG2000-PLA) was synthesized. The compound solution was injected in triplicate examination, in the air sac of the eggs, at third day of incubation, and survived fraction of the embryos and Morphological and skeletal changes were recorded . Results: The survived fraction of the embryos depends on the compound concentration. In concentration of 20 mg/ml , 33.3% of the embryos were survived and the LD50 was 10.87 mg/egg . Morphological study of the treated embryos showed no abnormalities in embryos , and skeletal staining showed the deletion of caudal vertebrate in high concentration. Conclusion: The BDP18 copolymer had low toxic and teratogenic effects against the embryos, but it caused the deletion of caudal vertebrate at concentrations above the threshold (10 mg/ml). This polymer can be used as an effective drug -release system in low concentrations .http://jarums.arums.ac.ir/browse.php?a_code=A-10-27-98&slc_lang=en&sid=1Tri-Block Copolymer BDP18; Cell Toxicity; Teratogenic; Chick Embryo |
| spellingShingle | Asadollah Asadi Arash Abdolmaleki Farhood Najafi Study of Teratogenic and Cytotoxic Effects of BDP18 Tri-Block Copolymer (PLA-PEG2000-PLA) on Chicken Embryos Journal of Ardabil University of Medical Sciences Tri-Block Copolymer BDP18; Cell Toxicity; Teratogenic; Chick Embryo |
| title | Study of Teratogenic and Cytotoxic Effects of BDP18 Tri-Block Copolymer (PLA-PEG2000-PLA) on Chicken Embryos |
| title_full | Study of Teratogenic and Cytotoxic Effects of BDP18 Tri-Block Copolymer (PLA-PEG2000-PLA) on Chicken Embryos |
| title_fullStr | Study of Teratogenic and Cytotoxic Effects of BDP18 Tri-Block Copolymer (PLA-PEG2000-PLA) on Chicken Embryos |
| title_full_unstemmed | Study of Teratogenic and Cytotoxic Effects of BDP18 Tri-Block Copolymer (PLA-PEG2000-PLA) on Chicken Embryos |
| title_short | Study of Teratogenic and Cytotoxic Effects of BDP18 Tri-Block Copolymer (PLA-PEG2000-PLA) on Chicken Embryos |
| title_sort | study of teratogenic and cytotoxic effects of bdp18 tri block copolymer pla peg2000 pla on chicken embryos |
| topic | Tri-Block Copolymer BDP18; Cell Toxicity; Teratogenic; Chick Embryo |
| url | http://jarums.arums.ac.ir/browse.php?a_code=A-10-27-98&slc_lang=en&sid=1 |
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