Proteolytic Cleavage of Receptor Tyrosine Kinases
The receptor tyrosine kinases (RTKs) are a large family of cell-surface receptors, which are essential components of signal transduction pathways. There are more than fifty human RTKs that can be grouped into multiple RTK subfamilies. RTKs mediate cellular signaling transduction, and they play impor...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/11/5/660 |
| _version_ | 1797535681017282560 |
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| author | Hao Huang |
| author_facet | Hao Huang |
| author_sort | Hao Huang |
| collection | DOAJ |
| description | The receptor tyrosine kinases (RTKs) are a large family of cell-surface receptors, which are essential components of signal transduction pathways. There are more than fifty human RTKs that can be grouped into multiple RTK subfamilies. RTKs mediate cellular signaling transduction, and they play important roles in the regulation of numerous cellular processes. The dysregulation of RTK signaling is related to various human diseases, including cancers. The proteolytic cleavage phenomenon has frequently been found among multiple receptor tyrosine kinases. More and more information about proteolytic cleavage in RTKs has been discovered, providing rich insight. In this review, we summarize research about different aspects of RTK cleavage, including its relation to cancer, to better elucidate this phenomenon. This review also presents proteolytic cleavage in various members of the RTKs. |
| first_indexed | 2024-03-10T11:48:48Z |
| format | Article |
| id | doaj.art-108465f986f546e5818c1ad9ed4d4a92 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T11:48:48Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-108465f986f546e5818c1ad9ed4d4a922023-11-21T17:50:55ZengMDPI AGBiomolecules2218-273X2021-04-0111566010.3390/biom11050660Proteolytic Cleavage of Receptor Tyrosine KinasesHao Huang0Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USAThe receptor tyrosine kinases (RTKs) are a large family of cell-surface receptors, which are essential components of signal transduction pathways. There are more than fifty human RTKs that can be grouped into multiple RTK subfamilies. RTKs mediate cellular signaling transduction, and they play important roles in the regulation of numerous cellular processes. The dysregulation of RTK signaling is related to various human diseases, including cancers. The proteolytic cleavage phenomenon has frequently been found among multiple receptor tyrosine kinases. More and more information about proteolytic cleavage in RTKs has been discovered, providing rich insight. In this review, we summarize research about different aspects of RTK cleavage, including its relation to cancer, to better elucidate this phenomenon. This review also presents proteolytic cleavage in various members of the RTKs.https://www.mdpi.com/2218-273X/11/5/660receptor tyrosine kinaseproteolytic cleavageproteasemetalloproteasesecretasecaspase |
| spellingShingle | Hao Huang Proteolytic Cleavage of Receptor Tyrosine Kinases Biomolecules receptor tyrosine kinase proteolytic cleavage protease metalloprotease secretase caspase |
| title | Proteolytic Cleavage of Receptor Tyrosine Kinases |
| title_full | Proteolytic Cleavage of Receptor Tyrosine Kinases |
| title_fullStr | Proteolytic Cleavage of Receptor Tyrosine Kinases |
| title_full_unstemmed | Proteolytic Cleavage of Receptor Tyrosine Kinases |
| title_short | Proteolytic Cleavage of Receptor Tyrosine Kinases |
| title_sort | proteolytic cleavage of receptor tyrosine kinases |
| topic | receptor tyrosine kinase proteolytic cleavage protease metalloprotease secretase caspase |
| url | https://www.mdpi.com/2218-273X/11/5/660 |
| work_keys_str_mv | AT haohuang proteolyticcleavageofreceptortyrosinekinases |